Serum total cholesterol serves as an independent risk factor for the progression of disease in idiopathic membranous nephropathy. DOI Creative Commons

Nan Chang,

Yue Wang, Xueli Bai

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Background This study sought to uncover potential risk factors linked disease development by analyzing the medical and renal histology features of individuals with idiopathic membranous nephropathy associated nephrotic syndrome. Methods Our retrospective research involved 373 patients who met specified inclusion criteria had a kidney biopsy diagnosis between January 2016 August 2023. The crowds recorded clinical pathological characteristics at baseline assessed outcomes during follow-up period. Researchers used binary logistic regression analysis identify progression in nephropathy. We categorized into two distinct groups: those progressing without. Results Thirty-six (9.65%) people experienced following an average period 15 (inter-quartile range 9,24) months. Serum total cholesterol levels substantial negative connection albumin, as evidenced Spearman's rho = -0.39 (p < 0.001). ROC curve for serum indicated sensitivity 69.4% specificity 76.9% predicting development. area beneath was 0.789 0.001, 95% CI: 0.725–0.852). Logistic multivariate revealed that blood (OR 1.554, 1.294–1.861, p 0.001) constitute independent factor Conclusion In syndrome, act separate danger indicator advancement.

Language: Английский

Western diet exacerbates a murine model of Balkan nephropathy DOI
Yuji Oe, Young Chul Kim,

Sadhana Kanoo

et al.

AJP Renal Physiology, Journal Year: 2024, Volume and Issue: 328(1), P. F15 - F28

Published: Dec. 17, 2024

This study shows that a Western diet (WD) aggravates murine model of Balkan nephropathy induced by the application organic anion and nephrotoxin aristolochic acid (AA). Mechanistically, this may involve WD-induced kidney secretion, which can facilitate AA uptake into proximal tubular cells thereby contribute to injury. Kidney proteomics identified further changes feeding WD could have increased sensitivity stress

Language: Английский

Citations

1
From Adipose to Ailing Kidneys: The Role of Lipid Metabolism in Obesity-Related Chronic Kidney Disease DOI Creative Commons
Wenchao Xu, Yuting Zhu, Siyuan Wang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1540 - 1540

Published: Dec. 16, 2024

Obesity has emerged as a significant public health crisis, closely linked to the pathogenesis and progression of chronic kidney disease (CKD). This review explores intricate relationship between obesity-induced lipid metabolism disorders renal health. We discuss how excessive free fatty acids (FFAs) lead accumulation in tissues, resulting cellular lipotoxicity, oxidative stress, inflammation, ultimately contributing injury. Key molecular mechanisms, including roles transcriptional regulators like PPARs SREBP-1, are examined for their implications dysregulation. The also highlights impact glomerular tubular overload on pathology, emphasizing podocytes cells maintaining function. Various therapeutic strategies targeting metabolism, pharmacological agents such statins SGLT2 inhibitors, well lifestyle modifications, discussed potential mitigate CKD obese individuals. Future research directions suggested better understand mechanisms linking develop personalized approaches. Ultimately, addressing obesity-related may enhance improve outcomes individuals suffering from CKD.

Language: Английский

Citations

1
Dysregulation of lipid metabolism in chronic kidney disease and the role of natural products DOI

Yang-Yi Jiang,

Xiaoli Jiang, Haining Yu

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 398(1), P. 261 - 278

Published: Aug. 20, 2024

Language: Английский

Citations

0
Causality of visceral adipose tissue on chronic kidney disease and renal function measure indicators, and mediation role of hypertension: Mendelian randomization study DOI Creative Commons

Teng‐Yu Gao,

J. Wang,

Qiudong Zhao

et al.

Obesity Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Summary Although chronic kidney disease (CKD) is associated with obesity, few studies have used visceral adipose tissue (VAT) as an indicator to investigate its causal effect on CKD. Therefore, Mendelian randomization (MR) was employed study the effects of VAT CKD and potential mediation by hypertension. Genome‐wide association (GWAS) statistics exposure were obtained from UK Biobank, while GWAS datasets outcomes CKDGen FinnGen (validation study). Furthermore, considered exposure, estimated glomerular filtration rate based creatinine (eGFR (crea)), cystatin C (eGFR(cys)), blood urea nitrogen (BUN) assess test indicators. Lastly, a two‐step MR method mediating role hypertension in pathogenesis among patients exhibited positive CKD, irrespective whether (odds ratio [OR] = 1.18, 95% CI: 1.08 1.29, P 1.433140e−04) or (1.47, 1.30 1.67, p 2.500000e−09). not causally eGFR (crea) (1.00, 0.99 1.00, 0.53), negatively (cys) (0.95, 0.93 0.97, 5.070000e−10), positively BUN (1.02,1.01 1.02, 7.824860e−04). The via 45.8% (95% 26.4 65.1). has playing significant role. However, renal function indicators require further investigation.

Language: Английский

Citations

0
Serum total cholesterol serves as an independent risk factor for the progression of disease in idiopathic membranous nephropathy. DOI Creative Commons

Nan Chang,

Yue Wang, Xueli Bai

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Background This study sought to uncover potential risk factors linked disease development by analyzing the medical and renal histology features of individuals with idiopathic membranous nephropathy associated nephrotic syndrome. Methods Our retrospective research involved 373 patients who met specified inclusion criteria had a kidney biopsy diagnosis between January 2016 August 2023. The crowds recorded clinical pathological characteristics at baseline assessed outcomes during follow-up period. Researchers used binary logistic regression analysis identify progression in nephropathy. We categorized into two distinct groups: those progressing without. Results Thirty-six (9.65%) people experienced following an average period 15 (inter-quartile range 9,24) months. Serum total cholesterol levels substantial negative connection albumin, as evidenced Spearman's rho = -0.39 (p < 0.001). ROC curve for serum indicated sensitivity 69.4% specificity 76.9% predicting development. area beneath was 0.789 0.001, 95% CI: 0.725–0.852). Logistic multivariate revealed that blood (OR 1.554, 1.294–1.861, p 0.001) constitute independent factor Conclusion In syndrome, act separate danger indicator advancement.

Language: Английский

Citations

0