Innovative Approaches to Boost Mesenchymal Stem Cells Efficacy in Myocardial Infarction Therapy

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101476 - 101476

Published: Jan. 9, 2025

Stem cell-based therapy has emerged as a promising approach for heart repair, potentially regenerating damaged tissue and improving outcomes patients with disease. However, the efficacy of stem therapies remains limited by several challenges, including poor cell survival, low retention rates, integration, functional outcomes. This article reviews current enhancement strategies to optimize mesenchymal cardiac repair. Key approaches include optimizing delivery methods, enhancing engraftment, promoting functions through genetic molecular modifications, paracrine effects cells, leveraging biomaterials engineering techniques. By focusing on these techniques, paper highlights innovative that can transform into more viable effective treatment option The ongoing research technological advancements continue push boundaries, hoping make mainstream

Language: Английский

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A Comprehensive Review on Graptopetalum paraguayense’s Phytochemical Profiles, Pharmacological Activities, and Development as a Functional Food

Plants, Journal Year: 2025, Volume and Issue: 14(3), P. 349 - 349

Published: Jan. 24, 2025

Graptopetalum paraguayense (G. paraguayense) is a succulent plant that has been used in traditional Chinese and Taiwanese medicine, mainly for antihypertensive hepatoprotective activities. G. also as an edible vegetable, which considered functional food. Different vitro, vivo, clinical studies have highlighted the multiple pharmacological activities of paraguayense, include anticancer, antibacterial, antiviral, antiasthma, antihypertensive, skin-whitening anti-aging, anti-Alzheimer, neuroprotective, Numerous revealed antioxidant anti-inflammatory potential may be major contributing factor protective effect on pancreatic, liver, lung, colon, brain diseases. Initial safety animal models support therapeutic candidature paraguayense. The presence numerous bioactive phytochemicals, especially polyphenols, identification important disease targets emphasize its high potential. lack directional approach limited vivo limit development against Still, compilation target pathways missing literature. current review not only compiles phytochemicals but highlights gaps proposes future directions developing candidate

Language: Английский

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Advances in intrahepatic and extrahepatic vascular dysregulations in cirrhotic portal hypertension

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 31, 2025

Cirrhotic portal hypertension, the most prevalent and clinically significant complication of liver cirrhosis, manifests as elevated venous pressure is associated with severe complications. Although much research on mechanisms hypertension has focused fibrosis, less attention been given to role intrahepatic extrahepatic vascular dysfunction, particularly respect vasculature. While hepatic fibrosis in cirrhotic undeniable, underlying involving vasculature are highly complex. Sinusoidal capillarization endothelial dysfunction contribute increased resistance. Hemodynamic changes circulation, including splanchnic vasodilation hyperdynamic play a development hypertension. Additionally, therapeutic strategies targeting these diverse, improvement sinusoidal microcirculation, therapies stellate cells activation, pharmacological modulation systemic tone. Therefore, this review, we will discuss vascular-related treatment progress cirrhosis provide new theoretical basis practical guidance for clinical treatment.

Language: Английский

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Kanglexin, a New Anthraquinone Compound, Inhibits Hepatic Fibrosis by Regulating Glutathione Metabolism with Pck1-Mediated Gluconeogenesis

Published: Jan. 1, 2025

Language: Английский

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An Integration of RNA Sequencing and Network Pharmacology Approaches Predicts the Molecular Mechanisms of the Huo-Xue-Shen Formula in the Treatment of Liver Fibrosis

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 227 - 227

Published: Feb. 7, 2025

Background: Liver fibrosis is a prevalent, chronic inflammatory condition characterized by the excessive accumulation of extracellular matrix components and, primarily, collagen in liver. Huo-xue-shen (HXS) has proven effective for treatment liver fibrosis. However, mechanism yet to be deciphered. Methods: Network pharmacology, machine learning algorithms and RNA-seq were used predict immune-treated targets mechanisms associated with HXS Molecular docking was employed screen agents based on drug-compound-hub gene network HXS, aiming identify most critical bioactive compound Results: A total 100 (ITTs) found significantly regulate PI3K-Akt signaling pathway MAPK pathway. Among these, CDKN1A, NR1I3, TUBB1, which can concurrently interact quercetin, prognosis fibrosis, indicating that may inhibit or reverse HSC activation primarily suppressing neutrophil trap formation, stimulating oxidative phosphorylation promoting thyroid hormone synthesis regulation microenvironment. Conclusions: Our study suggests delay progression targeting multiple pathways, as shown pharmacology transcriptome profiling examine immune environment. Quercetin, its key ingredient, likely plays an important role mediating TUBB1 pathways. Overall, our findings provide new perspective potential biological this traditional Chinese medicine formula.

Language: Английский

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Targeting Matrix Metalloproteinase-1, Matrix Metalloproteinase-7, and Serine Protease Inhibitor E1: Implications in preserving lung vascular endothelial integrity and immune modulation in COVID-19

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141602 - 141602

Published: Feb. 28, 2025

Language: Английский

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Liver Extracellular Matrix in Colorectal Liver Metastasis

Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 953 - 953

Published: March 12, 2025

The liver is the most common site of metastasis colorectal cancer (CRC), and one major causes CRC-related deaths worldwide. tumor microenvironment, particularly extracellular matrix (ECM), plays a critical role in CRC chemoresistance. Based on findings from clinical basic research, this review attempts to offer complete understanding ECM suggest potential ways for therapeutic intervention. First, ECMs’ regulating cell fate explored. We then discuss hepatic fingerprint its influence metastatic behavior cells, highlighting key molecular interactions that promote metastasis. In addition, we examine how changes within niche contribute chemoresistance, focusing remodeling by stiffening activation specific signaling pathways. Understanding these mechanisms crucial development novel strategies overcome improve outcomes patients.

Language: Английский

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ETS-1 in tumor immunology: implications for novel anti-cancer strategies

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

ETS-1, a key member of the Erythroblast Transformation-Specific (ETS) transcription factor family, plays an important role in cell biology and medical research due to its wide expression profile strong transcriptional regulation ability. It regulates fundamental biological processes, including proliferation, differentiation, apoptosis, is involved tumorigenesis metastasis, promoting malignant behaviors such as angiogenesis, matrix degradation, migration. Given association between ETS-1 overexpression aggressive characteristics multiple malignancies, it represents promising therapeutic target cancer treatment. This study aims systematically analyze within tumor immune microenvironment, elucidating mechanisms initiation, progression, metastasis. also investigates differential across tissues adjacent normal tissues, exploring potential molecular marker for diagnosis prognosis.

Language: Английский

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Impact of plant-derived antioxidants on heart aging: a mechanistic outlook

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Heart aging involves a complex interplay of genetic and environmental influences, leading to gradual deterioration cardiovascular integrity function. Age-related physiological changes, including ventricular hypertrophy, diastolic dysfunction, myocardial fibrosis, increased arterial stiffness, endothelial are influenced by key mechanisms like autophagy, inflammation, oxidative stress. This review aims explore the therapeutic potential plant-derived bioactive antioxidants in mitigating heart aging. These compounds, often rich polyphenols, flavonoids, other phytochemicals, exhibit notable antioxidant, anti-inflammatory, cardioprotective properties. substances have intricate properties, ability scavenge ROS, enhance endogenous antioxidant defenses, regulate signaling pathways, impede fibrosis inflammation-promoting processes. By focusing on molecular linked cardiac aging, produced from plants provide significant promise reduce age-related decline improve general health. Through comprehensive analysis preclinical clinical studies, this work highlights associated with promising effects antioxidants. The findings may helpful for researchers identifying specific molecules preventive heart.

Language: Английский

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Mesenchymal stem cell therapy for ischemic cardiomyopathy: Research progress and prospects for application

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 10, 2025

This review aims to explore the research progress and application prospects of mesenchymal stem cells (MSCs) in treatment ischemic cardiomyopathy (ICM). ICM is a severe heart disease characterized by death myocardial due long-term ischemia, leading impaired function. MSCs have become one promising therapeutic methods for treating their unique anti-inflammatory, anti-apoptotic, immunomodulatory, pro-angiogenic properties. Studies shown that can improve function promoting neovascularization, reducing cell apoptosis, inhibiting inflammatory responses, regulating immune reactions. Additionally, be sourced from various tissues, including bone marrow, adipose tissue, umbilical cord/placenta, with different sources possessing distinct characteristics effects. Clinical studies indicated MSC therapy physical capacity left ventricular ejection fraction (LVEF) patients intractable angina, enhance perfusion overall infarction. However, issues such as mechanisms MSCs, optimal source, infusion routes, dose optimization still require further research. Future need address these transform clinical trials routine practice, thereby revolutionizing management prognosis ICM.

Language: Английский

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