Nutrients,
Journal Year:
2024,
Volume and Issue:
16(23), P. 4088 - 4088
Published: Nov. 27, 2024
Sirtuins
(SIRTs),
nicotine
adenine
dinucleotide
(+)-dependent
histone
deacetylases,
have
emerged
as
critical
regulators
in
many
signalling
pathways
involved
a
wide
range
of
biological
processes.
Currently,
seven
mammalian
SIRTs
been
characterized
and
are
found
across
number
cellular
compartments.
There
has
considerable
interest
the
role
brain
due
to
their
plethora
metabolic-
age-related
diseases,
including
involvement
learning
memory
function
physiological
pathophysiological
conditions.
Although
cognitive
declines
over
course
healthy
ageing,
neurological
disorders
Alzheimer's
disease
(AD)
can
be
associated
with
progressive
impairments.
This
review
aimed
report
integrate
recent
advances
understanding
dysfunction
context
AD.
We
also
reviewed
use
selective
and/or
natural
SIRT
activators
potential
therapeutic
agents
adjuvants
for
Nörodejeneratif
Hastalıklarda
Sirtuinler
ve
Mitokondriyal
Aktivite
Yasemin
ATICI
Zeynep
ÖKTEN
Sara
KASEBİ
Lipit
Metabolizmasının
Apolipoproteinlerin
Alzheimer
Hastalığına
Etkisi
Buse
SEMERCİ
ARIKAN
Mehmet
ERDEM
Tuğba
Raika
KIRAN
Hastalığının
Patofizyolojisi
Oksidatif
Stres
Abdullah
Kaan
YAĞIZ
Berat
AKTOLUN
İnme
Biyobelirteçleri
Yeşim
GÜVENÇ
DEMİRAĞCI
Kanserde
Terapötik
Hedef
Olarak
Axl
Reseptörü
İnhibitörleri
Hatibe
KARA
Prostat
Kanseri
Gamze
GÖK
Otoimmün
Tiroid
Hastalıkları
Fonksiyon
Testleri
Yavuz
ELBAŞ
Eylem
ÇAĞILTAY
Paraoksonaz
Enzim
Ailesi
Enzimlerinden
Homosistein
Tiyolaktonaz,
Aril
Esteraz
Aktivitelerine
Genel
Bir
Bakış
Neslihan
CİHAN
ÇALIŞGAN
Gül
KIRTIL
ŞENEŞ
Doğan
YÜCEL
Abstract
Objective
To
investigate
the
effect
of
dihydromyricetin
on
hypoxia-induced
neurons,
to
understand
hypoxic-ischemic
encephalopathy
(HIE).
Methods
Cortical
neurons
were
isolated
from
C57BL/6j
mice
(24
hour-year
old),
cultured,
and
subjected
4h
hypoxia
20h
reoxygenation
mimic
neonatal
encephalopathy.
After
(20μmol/L)
treatment
for
2h,
CCK-8
assay
was
used
analyze
neuronal
viability,
Hoechst33342/PI
double
staining
death,
Western
blotting
expression
Poly
ADP-ribose
(PAR)
polymer
protein
γ
H2AX,
comet
detect
DNA
damage,
immunofluorescence
observe
nuclear
translocation
apoptosis
inducing
factor,
2’,7’-dichlorodihydrofluorescein
diacetate
reactive
oxygen
species
(ROS).
Results
Compared
with
control
groups,
hypoxia-treated
exhibited
significantly
lower
activity,
higher
death
rate
high
expressions
PAR
could
also
induce
AIF
translocation,
increase
tail
content
length,
ROS
in
neurons;
after
treatment,
activity
increased,
rate,
levels,
H2AX
decreased,
inhibited,
length
decreased.
Conclusion
Dihydromyricetin
alleviate
damage
through
decreasing
levels
inhibiting
suggesting
that
may
have
protective
HIE.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(23), P. 4088 - 4088
Published: Nov. 27, 2024
Sirtuins
(SIRTs),
nicotine
adenine
dinucleotide
(+)-dependent
histone
deacetylases,
have
emerged
as
critical
regulators
in
many
signalling
pathways
involved
a
wide
range
of
biological
processes.
Currently,
seven
mammalian
SIRTs
been
characterized
and
are
found
across
number
cellular
compartments.
There
has
considerable
interest
the
role
brain
due
to
their
plethora
metabolic-
age-related
diseases,
including
involvement
learning
memory
function
physiological
pathophysiological
conditions.
Although
cognitive
declines
over
course
healthy
ageing,
neurological
disorders
Alzheimer's
disease
(AD)
can
be
associated
with
progressive
impairments.
This
review
aimed
report
integrate
recent
advances
understanding
dysfunction
context
AD.
We
also
reviewed
use
selective
and/or
natural
SIRT
activators
potential
therapeutic
agents
adjuvants
for
