Digital Chinese Medicine, Journal Year: 2024, Volume and Issue: 7(4), P. 405 - 418
Published: Dec. 1, 2024
Language: Английский
Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 28, 2024
Gut microecology,the complex community consisting of microorganisms and their microenvironments in the gastrointestinal tract, plays a vital role maintaining overall health regulating various physiological pathological processes. Recent studies have highlighted significant impact gut microecology on regulation uric acid metabolism. Natural products, including monomers, extracts, traditional Chinese medicine formulations derived from natural sources such as plants, animals, microorganisms, also been investigated for potential modulating According to research, The stability is crucial link products maintain healthy metabolism reduce hyperuricemia-related diseases. Herein, we review recent advanced evidence revealing bidirectional between And separately summarize key extracts herbal both aspects. In addition,we elucidated important mechanisms secondary diseases through microecology, especially by composition microbiota, mucosal barrier, inflammatory response, purine catalyzation, associated transporters. This may offer novel insight into its disorders management highlight perspective exploring therapeutic drugs products.
Language: Английский
Citations
7
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 330, P. 118182 - 118182
Published: April 15, 2024
Acute Gouty Arthritis (AGA) is characterized by a rapid inflammatory reaction caused the build-up of monosodium urate (MSU) crystals in tissues surrounding joints. This condition often associated with hyperuricemia, distinguished its symptoms intense pain, active inflammation, and swelling Traditional approaches AGA management fall short desired outcomes clinical settings. However, recent ethnopharmacological investigations have been focusing on potential Herbal Medicine (THM) various forms, exploring their therapeutic impact targets treatment. review briefly summarizes current pharmacological mechanisms THMs – including ingredients, extracts, prescriptions –in treatment AGA, discusses relevant molecular depth. The objective this study to offer extensive information reference point for exploration targeted using THMs. obtained scientific publications focused vitro vivo studies anti-AGA Medicines (THMs) conducted between 2013 2023. literature was collected from journals electronic databases, PubMed, Elsevier, ScienceDirect, Web Science, Google Scholar. retrieval analysis articles were guided keywords such as "acute gouty arthritis Chinese herbal medicine," prescription," immune cells," inflammation," NLRP3," miRNA," oxidative stress." We found that has large number targets, highlighting effectiveness through studies. ingredients can mitigate variety influencing macrophage polarization, neutrophils, T cells, natural killer (NK) addressing factors like NLRP3 inflammasome, signaling pathways, stress, miRNA multi-target interactions. properties THMs, components prescriptions, systematically summarized categorized based respective targets. phenolic, flavonoid, terpenoid alkaloid compounds are considered key improve AGA. achieve enhanced efficacy interactions multiple which main target. Nonetheless, given intricate composition traditional medicine, additional research required unravel underlying alleviate
Language: Английский
Citations
6
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118615 - 118615
Published: July 27, 2024
Language: Английский
Citations
6
Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(7), P. 3370 - 3400
Published: April 24, 2024
Abstract Gout, or hyperuricemia is a multifactorial and multi‐faceted metabolic disease that quite difficult to manage and/or treat. Conventional therapies such as non‐steroidal anti‐inflammatory drugs (NSAIDs) allopurinol, corticosteroids colchicine amongst others, have helped in its management treatment some extent. This study aimed compile analyze the different herbal remedies used of gout. A literature search was conducted from key databases (PubMed, ScienceDirect, Cochrane Library, Google Scholar) using relevant keywords via PRISMA model. Smilax riparia A.DC. Traditional Chinese Medicine many countries for therapeutic effect on lowering serum urate levels. No single able establish efficacy specific traditionally herb vitro, vivo, clinical studies. Patients were found use panoply natural remedies, mainly plants treat gout, which been validated extent by Nonetheless, further research needed better understand ethnopharmacological relationship remedies.
Language: Английский
Citations
5
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 336, P. 118618 - 118618
Published: July 26, 2024
Language: Английский
Citations
5
Separations, Journal Year: 2025, Volume and Issue: 12(4), P. 77 - 77
Published: March 28, 2025
Amomum villosum L. is a perennial herbaceous belonging to the ginger family. Due its unique aroma, it widely used in alcoholic beverages and food processing. Unfortunately, issues with bitterness sourness occur, which affect taste quality of processed products. In this study, non-volatile sour bitter substances were systematically isolated, purified, characterized through combination chromatographic separation techniques ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS). The results indicate that three compounds (DL-malic acid, protocatechuic p-hydroxybenzoic acid) one compound (catechin) identified for first time vitro anti-tumor activity was screened determined using Cell Counting Kit-8 (CCK-8) assays, 5-Ethynyl-2′-deoxyuridine (EdU) staining experiment, scratch assays. reveal substance catechin (25–100 μg/mL) exhibited significant inhibitory effects, inhibited proliferation migration human non-small cell lung cancer A549 cells dose-dependent mechanisms. This investigation also reveals influence different traditional extraction solvents on degree extracts, providing theoretical basis improving pharmacological utilization extracts.
Language: Английский
Citations
0
International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 525 - 539
Published: Feb. 1, 2024
Objective: This study aimed to evaluate the effect of traditional Chinese medicine (TCM) on endpoint events in patients with gouty arthritis (GA). Methods and Materials: A total 2091 hospitalized GA were followed up by telephone, propensity score matching (PSM) was used reduce potential bias design. Cox proportional risk model Kaplan-Meier survival curve utilized analyze impact time factors readmission patients. The differences laboratory indexes before after treatment between low high exposure groups compared, types frequencies medicines all counted. Association rule analysis performed investigate association TCM test or events. Results: After 1:1 PSM, 187 enrolled group non-TCM group. incidence readmission, new tophus, all-cause death lower than that (P < 0.05). regression showed TCM, NSAIDs uric acid lowering drug independent protective for readmission. enhanced prolongation combinations. curves indicated a significantly rate 0.01). Compared treatment, NLR, hs-CRP, UA, TC other improved 0.01); improvement TG more significant identified top 20 herbal 2 patent medicines. core drugs through can improve index include Yiyiren, Danshen, HQC, among others. network diagram intuitively shows relationship "improvement indicators" "the absence events". Conclusion: is associated reduced GA. Keywords: arthritis, cohort study, medicine, neutrophil lymphocyte ratio
Language: Английский
Citations
3
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 147, P. 107375 - 107375
Published: April 16, 2024
Language: Английский
Citations
3
European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 277, P. 116753 - 116753
Published: Aug. 11, 2024
Language: Английский
Citations
2