Mesenchymal stem cell application in pulmonary disease treatment with emphasis on their interaction with lung-resident immune cells DOI Creative Commons
Ali Hazrati,

Seyed Mohamad Javad Mirarefin,

Kosar Malekpour

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Due to the vital importance of lungs, lung-related diseases and their control are very important. Severe inflammatory responses mediated by immune cells were among leading causes lung tissue pathology damage during COVID-19 pandemic. In addition, uncontrolled cell can lead in other infectious non-infectious diseases. It is essential a way that leads homeostasis. Immunosuppressive drugs only suppress do not affect homeostasis reactions. The therapeutic application mesenchymal stem (MSCs), addition restoring homeostasis, promote regeneration through production growth factors differentiation into cells. However, communication between MSCs after treatment pulmonary essential, investigating this help develop clinical perspective. Different studies phase showed reverse fibrosis, increase regeneration, airway remodeling, reduce tissue. proliferation potential one mechanisms effects. Furthermore, they secrete exosomes function change function. Another important mechanism harmful with innate adaptive cells, which shift system toward regulatory hemostatic responses.

Language: Английский

Engineered exosomes and composite biomaterials for tissue regeneration DOI Creative Commons
Weikang Hu, Wang Wang, Zesheng Chen

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(5), P. 2099 - 2126

Published: Jan. 1, 2024

Exosomes, which are small vesicles enclosed by a lipid bilayer and released many cell types, widely dispersed have garnered increased attention in the field of regenerative medicine due to their ability serve as indicators diseases agents with therapeutic potential. Exosomes play crucial role mediating intercellular communication through transfer biomolecules, including proteins, lipids, RNA, other molecular constituents, between cells. The targeted transport proteins nucleic acids specific cells has potential enhance or impair biological functions. applications, they can be used alone combination approaches. examination unique attributes functions these factors emerged prominent study realm biomedical research. This manuscript summarizes origins properties exosomes, structural, biological, physical, chemical aspects. paper offers complete recent progress tissue repair medicine, emphasizing possible implications methods forthcoming regeneration attempts.

Language: Английский

Citations

20
Research Advances of Engineered Exosomes as Drug Delivery Carrier DOI Creative Commons
Lianghui Huang,

Enguang Wu,

Jiawei Liao

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(46), P. 43374 - 43387

Published: Nov. 9, 2023

Exosomes are nanoscale vesicles secreted by living cells that have similar membrane composition to parental and carry a variety of proteins, lipids, nucleic acids. Therefore, exosomes certain biological activities play an important role in intercellular communication. On the basis its potential as carrier for drug delivery systems, been engineered compensate shortage natural through various engineering strategies improving efficiency, enhancing targeting tissues organs, extending circulating half-life exosomes. This review focuses on loading drugs different strategies, discussions exosome surface modification summarizes advantages disadvantages strategies. In addition, this provides overview recent applications number refractory relapsable diseases. has provide reference further research development

Language: Английский

Citations

36
Exosomes derived from natural killer cells: transforming immunotherapy for aggressive breast cancer DOI
Abdulmalik Saleh Alfawaz Altamimi, M. Arockia Babu, Muhammad Afzal

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 18, 2025

Language: Английский

Citations

1
Molecular insights to therapeutic in cancer: role of exosomes in tumor microenvironment, metastatic progression and drug resistance DOI

Shikshya S. Panda,

Rajeev Kumar Sahoo,

Sambit K. Patra

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(8), P. 104061 - 104061

Published: June 18, 2024

Language: Английский

Citations

6
Innovative Strategies to Combat 5-Fluorouracil Resistance in Colorectal Cancer: The Role of Phytochemicals and Extracellular Vesicles DOI Open Access
Muttiah Barathan, Ahmad Khusairy Zulpa, Sook Luan Ng

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7470 - 7470

Published: July 8, 2024

Colorectal cancer (CRC) is a significant public health challenge, with 5-fluorouracil (5-FU) resistance being major obstacle to effective treatment. Despite advancements, 5-FU remains formidable due complex mechanisms such as alterations in drug transport, evasion of apoptosis, dysregulation cell cycle dynamics, tumor microenvironment (TME) interactions, and extracellular vesicle (EV)-mediated pathways. Traditional chemotherapy often results high toxicity, highlighting the need for alternative approaches better efficacy safety. Phytochemicals (PCs) EVs offer promising CRC therapeutic strategies. PCs, derived from natural sources, exhibit lower toxicity can target multiple pathways involved progression resistance. facilitate targeted delivery, modulate immune response, interact TME sensitize cells However, potential PCs engineered overcoming reshaping immunosuppressive underexplored. Addressing this gap crucial identifying innovative therapies enhanced reduced toxicities. This review explores multifaceted evaluates synergistic effects combining improve treatment while minimizing adverse effects. Additionally, it investigates by serving delivery vehicles modulating TME. By synthesizing current knowledge addressing research gaps, enhances academic understanding CRC, interdisciplinary involving revolutionizing therapy. Further clinical validation are essential translating these findings into improved patient outcomes.

Language: Английский

Citations

6
Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment DOI Creative Commons

Xingliang Fang,

Huanrong Lan,

Ketao Jin

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: May 23, 2023

Pancreatic cancer (PC) is one of the most dangerous diseases that threaten human life, and investigating details affecting its progression or regression particularly important. Exosomes are derivatives produced from different cells, including tumor cells other such as Tregs, M2 macrophages, MDSCs, can help growth. These exosomes perform their actions by in microenvironment, pancreatic stellate (PSCs) produce extracellular matrix (ECM) components immune responsible for killing cells. It has also been shown cell (PCC)-derived at stages carry molecules. Checking presence these molecules blood body fluids us early stage diagnosis monitoring PC. However, system cell-derived (IEXs) mesenchymal stem (MSC)-derived contribute to PC treatment. Immune part mechanisms involved surveillance cell-killing phenomenon. be modified a way antitumor properties enhanced. One methods drug loading exosomes, which significantly increase effectiveness chemotherapy drugs. In general, form complex intercellular communication network plays role developing, progressing, diagnosing, monitoring, treating cancer.

Language: Английский

Citations

15
Engineering strategies of biomaterial-assisted exosomes for skin wound repair: Latest advances and challenges DOI
Yang Xu, Le Ma, Yang Wang

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 36(1), P. 109766 - 109766

Published: March 13, 2024

Language: Английский

Citations

5
Hydrogel encapsulation of mesenchymal stem cells-derived extracellular vesicles as a novel therapeutic approach in cancer therapy DOI
Raheleh Farahzadi, Ezzatollah Fathi, Somayeh Vandghanooni

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(5), P. 189177 - 189177

Published: Aug. 30, 2024

Language: Английский

Citations

5
The role of exosomes in bladder cancer immunotherapy DOI Creative Commons
Mohammad Mousaei Ghasroldasht, Piyush K. Agarwal

Journal of the National Cancer Center, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Preproinsulin-specific regulatory T cell-derived exosomes loaded with immune checkpoint ligands can suppress autoimmune responses in type 1 diabetes DOI Creative Commons
Preetam Basak, Devi Dayal, Sanjay Kumar Bhadada

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Background Type 1 diabetes (T1D) is an autoimmune disease, caused by selective destruction of pancreatic beta cells, mediated mainly infiltrating CD8 + T cells. These cells also express immune checkpoint molecules (ICMs) which can be targeted specific ligands (ICLs) as well cell-specific regulatory (Tregs) to induce immunosuppression. Methods We first performed profiling various ICMs on the peripheral in 40 recent-onset T1D and 20 age-matched healthy subjects flow cytometry. Tregs were isolated from same stimulated with preproinsulin (PPI) in vitro generate PPI-specific Tregs. Exosomes characterized western blotting, transmission electron microscopy, zeta potential, particle size analysis. Based cytometry data, we chose ICLs binding 3 most abundant (PD-1, TIGIT, BTLA) expressed for loading exosomes. The was optimized sonication ICL-loaded exosomes (PPI-T-EXOL) recharacterized. PPI-T-EXOL infused assessed separately suppressing cell proliferation, activation autologous PPI-pulsed protection. Finally, mice-specific administered STZ-induced diabetic C57BL/6 mice inhibit pathogenesis. Results showed similar stability naive efficiency incorporation ICL PPI-Treg almost 50%. inhibited proliferation CD4 vitro. PPI-Tregs significant suppression perforin, granzyme B, IFN-gamma markers, C69 CD71 PPI-T-EXOL-infused protected (1.1B4 line) cell-mediated apoptosis. Further, mice, delayed onset hyperglycemia, particularly when before diabetes. treatment partially controlled prolonged survival, reduced perivascular intra-islet lymphocytic infiltration, greater preservation Conclusions Our results suggest that PPI-Treg-derived loaded suppress responses, offering a promising therapeutic intervention T1D.

Language: Английский

Citations

0