Cell Biology and Toxicology,
Journal Year:
2025,
Volume and Issue:
41(1)
Published: March 5, 2025
Recently,
infertility
has
emerged
as
a
significant
and
prevalent
public
health
concern
warranting
considerable
attention.
Apoptosis,
recognized
programmed
cell
death,
constitutes
crucial
process
essential
for
the
maintenance
of
normal
spermatogenesis.
Multiple
investigations
have
illustrated
that
dysregulated
apoptosis
reproductive
cells,
encompassing
spermatogonial
stem
Sertoli
Leydig
serves
causative
factor
in
male
infertility.
MicroRNAs
represent
class
small
RNA
molecules
exert
negative
regulatory
control
over
gene
expression
using
direct
interaction
with
messenger
transcripts.
Previous
studies
established
aberrant
miRNAs
induces
tissues,
correlating
dysfunctions
In
this
review,
we
offer
comprehensive
overview
their
respective
target
genes
implicated
apoptotic
process.
As
well,
are
involved
multiple
signaling
pathways,
namely
PI3K/AKT,
NOTCH,
Wnt/β-catenin,
mTOR
cascades,
exerting
both
positive
effects.
We
additionally
elucidate
functions
played
by
lncRNAs
circular
RNAs
competing
endogenous
within
cells.
further
illustrate
external
factors,
including
silica
nanoparticles,
Cyclosporine
A,
smoking,
induce
dysregulation
miRNAs,
resulting
cells
subsequent
toxicity.
Further,
discuss
implication
heat
stress,
hypoxia,
diabetes
induced
miRNA
Finally,
demonstrate
modulation
via
traditional
novel
medicine
could
protect
from
be
implemented
therapeutic
approach
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: July 4, 2024
Germ
cell
development
in
mammals
is
a
complex
physiological
process
that
involves
the
proliferation
of
primordial
germ
cells,
meiosis,
and
formation
male
female
gametes.
Long
non-coding
RNA
(lncRNA)
type
with
more
than
200
nucleotides
does
not
code
for
proteins.
A
small
number
lncRNAs
have
been
shown
to
participate
spermatogenesis
testes
follicular
ovaries,
but
role
vast
majority
their
molecular
mechanisms
still
need
further
study.
LncRNA
Gm2044
was
identified
as
differentially
expressed
lncRNA
mouse
by
microarray
technology.
In
testis,
can
act
competing
endogenous
regulate
SYCP1
expression
GC-2
cells
derived
from
spermatocyte
it
also
host
gene
miR-202
RBFOX2
protein
expression.
regulates
17β-estradiol
synthesis
through
miRNA-138-5p-Nr5a1
pathway
or
interacting
EEF2.
addition,
studies
suggest
involved
progression
reproductive
system
diseases
such
nonobstructive
azoospermia.
Here,
we
summarize
roles
gametogenesis
its
potential
some
infertility
disorders.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1382 - 1382
Published: Feb. 6, 2025
Palatogenesis
is
a
complex
developmental
process
requiring
temporospatially
coordinated
cellular
and
molecular
events.
The
following
review
focuses
on
genetic,
epigenetic,
environmental
aspects
directing
palatal
formation
their
implication
in
orofacial
clefting
genesis.
Essential
for
shelf
development
elevation
(TGF-β,
BMP,
FGF,
WNT),
the
subsequent
processes
of
fusion
(SHH)
proliferation,
migration,
differentiation,
apoptosis
neural
crest-derived
cells
are
controlled
through
signaling
pathways.
Interruptions
to
these
may
result
birth
defect
cleft
lip
and/or
palate
(CL/P),
which
happens
approximately
1
every
700
live
births
worldwide.
Recent
progress
has
emphasized
epigenetic
regulations
via
class
non-coding
RNAs
with
microRNAs
based
critically
important
biological
processes,
such
as
apoptosis,
epithelial–mesenchymal
transition.
These
risks
(maternal
smoking,
alcohol,
retinoic
acid,
folate
deficiency)
interact
genetic
factors
during
palatogenesis,
while
teratogens
like
dexamethasone
TCDD
inhibit
fusion.
In
cleft,
impact
epidemiology.
This
an
extensive
review,
offering
current
perspectives
gene-environment
interactions,
well
RNAs,
palatogenesis
emphasizing
open
questions
regarding
interactions
development.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Abstract
Recent
advancements
in
microRNAs
(miRNAs)
research
have
revealed
their
key
roles
both
normal
physiological
processes
and
pathological
conditions,
leading
to
potential
applications
diagnostics
therapeutics.
However,
the
path
forward
is
fraught
with
several
scientific
technical
challenges.
This
review
article
briefly
explores
milestones
of
discovery,
biogenesis,
functions,
application
for
clinical
diagnostic
therapeutic
strategies
miRNAs.
The
challenges
future
directions
are
also
discussed
fully
harness
capabilities.
Briefings in Bioinformatics,
Journal Year:
2024,
Volume and Issue:
25(2)
Published: Jan. 22, 2024
Connections
between
circular
RNAs
(circRNAs)
and
microRNAs
(miRNAs)
assume
a
pivotal
position
in
the
onset,
evolution,
diagnosis
treatment
of
diseases
tumors.
Selecting
most
potential
circRNA-related
miRNAs
taking
advantage
them
as
biological
markers
or
drug
targets
could
be
conducive
to
dealing
with
complex
human
through
preventive
strategies,
diagnostic
procedures
therapeutic
approaches.
Compared
traditional
experiments,
leveraging
computational
models
integrate
diverse
data
order
infer
associations
proves
more
efficient
cost-effective
approach.
This
paper
developed
model
Convolutional
Autoencoder
for
CircRNA-MiRNA
Associations
(CA-CMA)
prediction.
Initially,
this
merged
natural
language
characteristics
circRNA
miRNA
sequence
features
circRNA-miRNA
interactions.
Subsequently,
it
utilized
all
pairs
construct
molecular
association
network,
which
was
then
fine-tuned
by
labeled
samples
optimize
network
parameters.
Finally,
prediction
outcome
is
obtained
utilizing
deep
neural
networks
classifier.
innovatively
combines
likelihood
objective
that
preserves
neighborhood
optimization,
learn
continuous
feature
representation
words
preserve
spatial
information
two-dimensional
signals.
During
process
5-fold
cross-validation,
CA-CMA
exhibited
exceptional
performance
compared
numerous
prior
approaches,
evidenced
its
mean
area
under
receiver
operating
characteristic
curve
0.9138
minimal
SD
0.0024.
Furthermore,
recent
literature
has
confirmed
accuracy
25
out
top
30
identified
highest
scores
during
case
studies.
The
results
these
experiments
highlight
robustness
versatility
our
model.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(8), P. 4548 - 4548
Published: April 21, 2024
Colorectal
cancer
(CRC)
is
the
third
most
prevalent
to
be
diagnosed,
and
it
has
a
substantial
mortality
rate.
Despite
numerous
studies
being
conducted
on
CRC,
remains
significant
health
concern.
The
disease-free
survival
rates
notably
decrease
as
CRC
progresses,
emphasizing
urgency
for
effective
diagnostic
therapeutic
approaches.
development
caused
by
environmental
factors,
which
mostly
lead
disruption
of
signaling
pathways.
Among
these
pathways,
Wingless/Integrated
(Wnt)
pathway,
Phosphatidylinositol
3-kinase/protein
kinase
B/mammalian
target
rapamycin
(PI3K/AKT/mTOR)
Mitogen-Activated
Protein
Kinase
(MAPK)
Transforming
Growth
Factor-β
(TGF-β)
p53
pathway
are
considered
important.
These
pathways
also
regulated
non-coding
RNAs
(ncRNAs),
including
microRNAs
(miRNAs),
long
(lncRNAs),
circular
(circRNAs).
They
have
emerged
crucial
regulators
gene
expression
in
changing
their
levels.
altered
patterns
ncRNAs
been
implicated
progression
development,
suggesting
potential
targets.
This
review
provides
an
overview
five
key
regulation
involved
pathogenesis
that
studied
identify
promising
avenues
diagnosis
treatment
strategies.
Non-coding RNA Research,
Journal Year:
2024,
Volume and Issue:
9(3), P. 811 - 830
Published: March 30, 2024
Cancer
is
a
broad
name
for
group
of
diseases
in
which
abnormal
cells
grow
out
control
and
are
characterized
by
their
complexity
recurrence.
Although
there
has
been
progress
cancer
therapy
with
the
entry
precision
medicine
immunotherapy,
incidence
rates
have
increased
globally.
Non-coding
RNAs
form
circular
(circRNAs)
play
crucial
roles
pathogenesis,
clinical
diagnosis,
different
diseases,
including
cancer.
According
to
recent
studies,
circRNAs
appear
serve
as
accurate
indicators
therapeutic
targets
treatment.
However,
promising
candidates
cutting-edge
because
distinctive
structure,
stability,
wide
range
capabilities;
many
challenges
persist
that
decrease
applications
circRNA-based
therapeutics.
Here,
we
explore
replacement
therapy,
highlight
main
facing
therapies,
discuss
key
strategies
overcome
these
improve
advanced
innovative
therapies
based
on
long-term
health
effects.
Non-Coding RNA,
Journal Year:
2025,
Volume and Issue:
11(1), P. 14 - 14
Published: Feb. 8, 2025
Osteoporosis
is
a
complex
disease
that
affected
by
variety
of
factors,
including
genetic
and
epigenetic
influences.
While
DNA
markers
for
osteoporosis
have
been
identified,
they
do
not
fully
explain
the
hereditary
basis
disease.
Epigenetic
such
as
small
microRNAs
(miRNAs),
may
provide
missing
link
in
understanding
molecular
mechanisms
underlying
osteoporosis.
miRNAs
are
class
non-coding
RNAs
play
role
regulation
gene
expression.
They
known
to
be
involved
various
biological
processes,
bone
formation
remodelling.
Differential
expression
has
linked
pathological
decrease
mineral
density
associated
with
It
shown
an
abnormal
miRNA
pattern
leads
osteoblast
activity
increase
osteoclast
activity.
Further
research
into
help
better
understand
this
identify
potential
therapeutic
targets
treatment.
Based
on
these
assumptions,
study
patterns
osteoblasts,
osteoclasts,
their
precursors
under
normal
osteoporotic
conditions
rapidly
growing
field
scientific
research.
Although
results
still
incomplete
sometimes
contradictory,
require
additional
analysis
involved.
The
purpose
paper
review
current
specifically
expressed
osteoblasts
osteoclasts
both
conditions.
We
will
also
discuss
applications
biomarkers
diagnosis
