Biological agents as attractive targets for inflammatory bowel disease therapeutics DOI Creative Commons

Jia-Chen Xue,

Xiao-Ting Hou,

Yuwei Zhao

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 167648 - 167648

Published: Dec. 1, 2024

Inflammatory bowel disease (IBD) refers to a group of chronic, recurrent intestinal inflammatory conditions with complex cause and unclear underlying mechanisms. It includes two main types: ulcerative colitis (UC) Crohn's (CD). The conventional treatment IBD mainly 5-aminosalicylates, glucocorticoids, immunosuppressive drugs, which have their limitations. Recent advancements in research expanded options, biological agents playing key role. Anti-tumor necrosis factor alpha has emerged as the first-line therapy for moderate severe IBD. Anti-integrin antibodies also become important disease, vedolizumab is often used cases anti-tumor factor-alpha failure intolerance other treatments. Other are being tested clinical trials at different stages. This article reviews efficacy safety primary therapies provides comprehensive analysis current challenges associated disease.

Language: Английский

Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms DOI
Najmeh Oliyaei, S. Zekri, Aida Iraji

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106690 - 106690

Published: Jan. 28, 2025

Language: Английский

Citations

1
Management of Fibromyalgia: Novel Nutraceutical Therapies Beyond Traditional Pharmaceuticals DOI Open Access
A. Antonelli, Marzia Bianchi, Elizabeth J. Fear

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 530 - 530

Published: Jan. 31, 2025

The pathophysiology of fibromyalgia, a condition that causes chronic pain throughout the body, involves abnormal signaling, genetic predispositions, and neuroendocrine function, significantly impairing quality life. Fibromyalgia is commonly characterized by musculoskeletal pain, fatigue, severe sleep alterations. Changes in central processing sensory input defects endogenous inhibition could be basis enhanced persistent sensitivity individuals with fibromyalgia. term syndrome was chosen as an umbrella for fibromyalgia related illnesses, including myalgic encephalomyelitis/chronic fatigue syndrome, migraine, irritable bowel syndrome. Given substantial impact on health, there need new prevention treatment strategies, particularly those involving bioavailable nutraceuticals and/or phytochemicals. This approach important considering adverse effects current pharmaceutical treatments, such antidepressants anticonvulsants, which can lead to physical dependence tolerance. Natural products have recently been considered design innovative analgesics antinociceptive agents manage pain. Polyphenols show promise management neuropathic especially how anti-inflammatory corticosteroids nonsteroidal medical drugs, are effective only when inflammatory processes coexist not recommended primary

Language: Английский

Citations

0
Microbiomes in action: multifaceted benefits and challenges across academic disciplines DOI Creative Commons
Sereyboth Soth, J. G. Hampton, Hossein Alizadeh

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Microbiomes combine the species and activities of all microorganisms living together in a specific habitat. They comprise unique ecological niches with influences that scale from local to global ecosystems. Understanding connectivity microbiomes across academic disciplines is important help mitigate climate change, reduce food insecurity, control harmful diseases, ensure environmental sustainability. However, most publications refer individual microbiomes, those integrating two or more related are rare. This review examines multifaceted benefits agriculture, manufacturing preservation, natural environment, human health, biocatalyst processes. Plant by improving plant nutrient cycling increasing abiotic biotic stress resilience, have increased crop yields over 20%. Food generate approximately USD 30 billion economy through fermented industry alone. Environmental detoxify pollutants, absorb than 90% heavy metals, facilitate carbon sequestration. For an adult person can carry up 38 trillion microbes which regulate well being, immune functionality, reproductive function, disease prevention. used optimize processes produce bioenergy biochemicals; bioethanol production alone valued at 83 p.a. challenges, including knowledge gaps, engaging indigenous communities, technical limitations, regulatory considerations, need for interdisciplinary collaboration, ethical issues, must be overcome before potential effectively realized.

Language: Английский

Citations

0
Distinct Effects of Lactiplantibacillus plantarum HNU082 on Microbial Single-Nucleotide Variants in Large Intestine and Small Intestine DOI Creative Commons

Wenyao Ma,

Zhe Han, Xinlei Liu

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 731 - 731

Published: March 25, 2025

The intestinal tract extends several times the length of bodies, with varying environmental conditions across different segments (small and large intestinal), thereby harboring distinct gut microbiota. Most studies focused on quantitative responses microbiota upon probiotics entering gut, without an in-depth analysis how genetic change in local Therefore, this experiment, C57BL/6J male mice were once administered Lactiplantibacillus plantarum HNU082 (Lp082). Then, euthanized 1st, 3rd, 7th days after gavage, contents small intestines scraped for metagenomic analysis. Based characterization intestine bacteria, changes diversity abundance single-nucleotide variants (SNVs) analyzed. There observable at level. A significant number SNVs identified Ligilactobacillus murinus intestine. These may impact utilization carbohydrates L. murinus. Ingested traversed entire interacted indigenous microbiota, driving evolution segments, influencing microbial growth metabolism. This study investigates role It offers new probiotic insights a basis targeted interventions.

Language: Английский

Citations

0
DAMP-ing IBD: Extinguish the Fire and Prevent Smoldering DOI Creative Commons

Oliver Sandys,

Pieter Stokkers,

Anje A. te Velde

et al.

Digestive Diseases and Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: July 4, 2024

In inflammatory bowel diseases (IBD), the most promising therapies targeting cytokines or immune cell trafficking demonstrate around 40% efficacy. As IBD is a multifactorial inflammation of intestinal tract, single-target approach unlikely to solve this problem, necessitating an alternative strategy that addresses its variability. One often overlooked by pharmaceutically driven therapeutic options address impact environmental factors. This somewhat surprising considering increasingly viewed as condition heavily influenced such factors, including diet, stress, and pollution-often referred "Western lifestyle". IBD, responses result from complex interplay among genetic background patient, molecules, cells, local microenvironment where danger- microbe-associated molecular patterns (D/MAMPs) provide adjuvant-rich environment. Through activating DAMP receptors, array pro-inflammatory factors can stimulate, for example, NLRP3 inflammasome-a major amplifier response in various cells via non-specific bystander activation myeloid (e.g., macrophages) lymphocytes tissue-resident memory T cells). Current biological treatment approaches dampen response, but without reducing exposure e.g., changing diet (reducing ultra-processed foods), landscape never resolved continues drive mucosal dysregulation. Thus, are not enough put out fire. The resultant smoldering, low-grade diminishes physiological resilience (micro)environment, perpetuating state chronic disease. Therefore, our hypothesis posits successful interventions must complexity disease simultaneously all modifiable aspects: innate immunity microbiota, adaptive cytokines, relate (micro)environment. Thus be comprehensively treated across nano-, meso-, microscales, rather than with focus on single targets. A broader perspective also includes adapt DAMPing (micro)environment warranted.

Language: Английский

Citations

3
Solid‐state fermentation pro‐enzymes supplementation benefits growth performance, health, and intestinal microbiota of broiler chickens fed wheat‐based diet DOI Creative Commons
Jiaheng Li,

Guosong Bai,

Yan Gao

et al.

Animal Research and One Health, Journal Year: 2024, Volume and Issue: unknown

Published: March 7, 2024

Abstract Wheat as a kind of diet material can be used for broiler production. However, due to non‐starch polysaccharides in wheat, wheat may lead lower growth performance and worth health. To reverse the negative effect, solid‐state fermentation pro‐enzymes were added. In this experiment, performance, intestinal health‐related genes, short chain fatty acids (SCFAs) microbiota detected find effects meal combined with enzymes on chickens from 15 42 days age. A total 432 1‐day‐old Arbor Acres fed corn‐based (CD) 14 preparation stage experiment. Then, they randomly divided into three groups different kinds diets which (CD group), wheat‐based (WD SFP supplementation WD (Enzymes+Wheat‐based group). The results showed that compared broilers CD group, group had weight gain higher Feed conversion ratio ( p < 0.05) during whole experimental period especially day 21, but there was no significant effect feed intake > 0.05). Moreover, decreased spleen index also trends decrease expression ZO‐1 = 0.096) increase concentrations acetate 0.05), butyrate SCFAs caused opposite except butyrate, even increased 0.001) OCCLUDIN 0.075) TNF‐α 0.01). Meanwhile, enhanced abundances Barnesiella Bifidobacterium inhibited Flavonifractor , Sellimonas Lachnospiraceae_NK4A136_group Subdoligranulum Ruminococcus_gauvreauii_group could effects, changes explain other parameters. Collectively, inflammation worse benefits chickens' by improving barrier function, decreasing inflammation, modulating cecal

Language: Английский

Citations

2
Colon-targeted delivery of polyphenols: construction principles, targeting mechanisms and evaluation methods DOI
Yidi Wang, Zhiying Li, Yiwen Bao

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 23

Published: Oct. 12, 2023

AbstractPolyphenols have received considerable attention for their promotive effects on colonic health. However, polyphenols are mostly sensitive to harsh gastrointestinal environments, thus, must be protected. It is necessary design and develop a colon-targeted delivery system improve the stability, colon-targeting bioavailability of polyphenols. This paper mainly introduces research controlled release The physiological features affecting dissolution, absorption polyphenol-loaded systems in colon first discussed. Simultaneously, types carriers with different mechanisms described, assessment models that been studied so far advantages limitations summarized. Based current colon-targeting, outlook reflections proposed, goal inspiring strategic development new therapeutics ensure reach complete bioactivity.Keywords: Colonic targetingpolyphenolscontrolled releaseconstruction principlesdelivery Authors' contributionsYidi Wang: Conceptualization-Equal, Data curation-Equal, Investigation-Equal, Writing – original draft; Zhiying Li: Formal analysis; Yiwen Bao: Investigation-Equal; Huijun Cui: Project administration-Equal; Jiaxin Methodology-Equal; Xingyue Resources-Equal; Mengzhu Baoge Song: Methodology-Equal, Haikun Yi Chen: Resources-Equal, Supervision-Equal; WeiChen: administration-Equal, Shufang Yang: Yiyun Zhufeng Jin: Xu Si: Funding acquisition-Equal, Software, Supervision-Equal, Validation, review & editing; Bin Supervision-Equal.Disclosure statementNo potential conflict interest was reported by author(s).Additional informationFundingThis work supported National Natural Science Foundation China [U21A20273], Central Government-guided local Technology Fund [2023JH6/100500010] Scientific Research Projects Liaoning Province [LSNQN202010].

Language: Английский

Citations

4
High-Throughput Sequencing Analysis Revealed a Preference for Animal-Based Food in Purple Sea Urchins DOI Creative Commons

Zerui Liu,

Yu Guo, Chuanxin Qin

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(8), P. 623 - 623

Published: Aug. 15, 2024

Sea urchins play an important role in marine ecosystems. Owing to limitations previous research methods, there has been insufficient understanding of the food sources and ecological functional value purple sea urchins, leading considerable controversy regarding their positioning. We focused on Daya Bay as area, utilizing stable isotope technology high-throughput sequencing 16S rDNA 18S analyze potential stone algae areas. The results showed that δ13C range area is −11.42~−8.17‰, δ15N 9.15~10.31‰. However, algal −13.97~−12.44‰, 8.75~10.14‰. There was a significant difference between two areas (p < 0.05), but no > 0.05). main source for both sediment. revealed that, highest proportion urchin gut Molluska (57.37%). In Arthropoda (76.71%). Bacteroidetes dominant group (28.87%), whereas, Proteobacteria (37.83%). Diversity detection number microbes eukaryotes sediment, organic nutritional greater richness microbiota greater. These indicated are likely omnivores where they occur impacts growth development. this study provide theoretical basis restoration wild resources selection restocking release.

Language: Английский

Citations

1
Contribution of the Gut Microbiome to the Perpetuation of Inflammation in Crohn's Disease: A Systematic Review DOI Open Access

Sai Pavitra Paidimarri,

Shriya Ayuthu,

Yashkumar D Chauhan

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 24, 2024

Crohn's disease (CD) is a sub-type of inflammatory bowel (IBD) with characteristic relapsing and remitting inflammation involving the gastrointestinal (GI) tract. Although there are several medications to relieve symptoms, no definite cure for condition. This paper highlights how CD affects our gut flora, which subsequently leads perpetuation inflammation. review was conducted according Preferred Reporting Items Systematic Review Meta-Analysis (PRISMA) 2020 guidelines using PubMed, ScienceDirect, Multidisciplinary Digital Publishing Institute (MDPI), Google Scholar as sources relevant literature. After applying quality appraisal tools, we finalized 11 articles paper. Inflammation seen in dysbiosis, where reduction beneficial microbes such

Language: Английский

Citations

1
Intestinal microecology dysbiosis in inflammatory bowel disease: Pathogenesis and therapeutic strategies DOI
Yue Yin,

Weibo Feng,

Xilang Chen

et al.

The Innovation Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 100092 - 100092

Published: Jan. 1, 2024

<p>Inflammatory bowel disease (IBD) is an autoimmune characterized by non-infectious, chronic, and recurrent inflammation in the intestine, with unclear pathogenesis increasing incidence. Currently, immunosuppressive drugs are commonly used clinical treatment of IBD to alleviate intestinal inflammation, but their effectiveness not ideal. Therefore, it crucial investigate develop new therapeutic strategies. As a significant component barrier, microbiota closely related metabolism, barrier protection, immune regulation. With advances research technology, pivotal role microecology dysbiosis progression has gained attention recent years. Microbial therapies, including microecological modulators, fecal transplantation, phage therapy have also become hotspots treatment, showing promising applications. However, complex relationship between remains unclear, trials investigating microbial therapies face limitations. To inspire further research, this review thoroughly summarizes physiological structure function microecology, as well characteristics patients. We analyze status for application organoid models preclinical studies.</p>

Language: Английский

Citations

1