:
This
Systematic
Review
focused
on
the
use
of
Bifidobacterium
infantis
and
breve
in
neurodegenerative
diseases.
The
study
metabolomics
has
demonstrated
relationship
between
dysbiosis
neuronal
death.
modulation
gut
microbiota
intervention
these
pathologies
become
a
promising
area
study,
showing
beneficial
results
such
as
improvement
synaptic
function,
reduction
neuroinflammation,
well
associated
neuropsychiatric
symptoms.
Several
studies
have
addressed
administration
breve,
alone,
conjunction
or
combination
with
other
strains,
includes
17
research
articles
(n=5
humans
n=12
animal
models)
main
result
was
that
produced
improvements
disease-related
symptomatology
degenerative
cellular
processes.
However,
some
shown
neutral
certain
variables.
These
data
suggest
probiotics
neuroprotective
effect
may
delay
progression
disease.
provides
relevant
updated
information
strains
Alzheimer's
disease
Parkinson's
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 3010 - 3010
Published: March 5, 2024
This
systematic
review
addresses
the
use
of
Lactiplantibacillus
(Lactobacillus)
plantarum
in
symptomatological
intervention
neurodegenerative
disease.
The
existence
gut
microbiota
dysbiosis
has
been
associated
with
systemic
inflammatory
processes
present
disease,
creating
opportunity
for
new
treatment
strategies.
involves
modifying
strains
that
constitute
to
enhance
synaptic
function
through
gut–brain
axis.
Recent
studies
have
evaluated
beneficial
effects
on
motor
and
cognitive
symptomatology,
alone
or
combination.
includes
20
research
articles
(n
=
3
human
n
17
animal
models).
main
result
this
was
combination
produced
improvements
symptomatology
related
However,
one
included
reported
negative
after
administration
plantarum.
provides
current
relevant
information
about
probiotic
pathologies
such
as
Alzheimer’s
Parkinson’s
disease
Multiple
Sclerosis.
Indian Journal of Pharmaceutical Education and Research,
Journal Year:
2025,
Volume and Issue:
59(1), P. 370 - 376
Published: Jan. 6, 2025
Background
Liver
cancer's
severity
has
prompted
interest
in
herbal
remedies
for
hepatotoxicity
and
the
disease.
Acacia
nilotica
(Vachellia
nilotica),
valued
its
traditional
medicinal
properties,
particularly
aerial
components,
is
being
investigated
hepatoprotective
anti-cancer
effects.
However,
research
on
A.
bark
extracts
their
mechanisms
of
action
limited.
Materials
Methods
The
study
aimed
to
determine
Total
Phenolic
Content
(TPC),
Flavonoid
(TFC),
antioxidant
properties
extract
using
biochemical
assays.
Additionally,
it
examined
protective
effects
normal
Cells
(LO2)
toxicity
against
liver
cancer
cells
(HepG2)
cell
culture
techniques.
Results
showed
significant
(EC50-16.34),
with
a
total
phenolic
content
159.98±9.91
mg
GAE/DW
flavonoid
16.93
QE/g
dry
weight.
It
exhibited
moderate
towards
HepG2
at
concentrations
>100
μg/mL
but
was
non-toxic
LO2
cells.
Moreover,
prevented
oxidative
damage
induced
by
H2O2.
Conclusion
These
findings
highlight
therapeutic
potential
treatment,
warranting
further
clinical
investigation.
Foods,
Journal Year:
2024,
Volume and Issue:
13(6), P. 924 - 924
Published: March 19, 2024
This
research
endeavored
to
elucidate
the
antioxidant
attributes
of
lactic
acid
bacteria,
specifically
their
impact
on
anti-aging
and
lifespan
augmentation
in
Caenorhabditis
elegans.
The
study
focused
Lactiplantibacillus
plantarum
A72,
identified
through
ARTP
mutagenesis
for
its
potent
properties.
In
vitro
analysis
affirmed
free
radical
neutralizing
capacity.
C.
elegans,
strain
not
only
extended
by
25.13%
amplified
motility
2.52-fold,
but
also
maintained
reproductive
capabilities.
Remarkably,
Lpb.
A72
diminished
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA)
levels
elegans
34.86%
69.52%,
respectively,
while
concurrently
enhancing
enzyme
activities.
bolstered
survival
rates
46.33%
57.78%
under
high
temperature
H2O2
conditions,
respectively.
Transcriptomic
scrutiny
revealed
that
could
retard
aging
extend
upregulating
sod-5
hsp-16.1
genes
downregulating
fat-6
lips-17
genes.
These
findings
propose
as
a
potential
bacteria.
Cells,
Journal Year:
2023,
Volume and Issue:
12(24), P. 2789 - 2789
Published: Dec. 7, 2023
Lactic
acid
bacteria
(LAB),
a
probiotic,
provide
various
health
benefits.
We
recently
isolated
new
Lactobacillus
paracasei
strain
with
strong
anti-inflammatory
effects
under
lipopolysaccharide-induced
conditions
and
proposed
mode
of
action—augmenting
the
endoplasmic
reticulum
stress
pathway
for
functions
in
host
cells.
The
beneficial
L.
strains
on
skin
have
been
described;
however,
paracasei-derived
extracellular
vesicles
(LpEVs)
are
poorly
understood.
Herein,
we
investigated
whether
LpEVs
can
improve
inflammation-mediated
phenotypes
by
determining
their
primary
human
cells
three-dimensional
(3D)
full-thickness
equivalent
tumor
necrosis
factor
(TNF)-α-challenged
inflammatory
conditions.
were
efficiently
taken
up
much
less
cytotoxic
to
than
bacterial
lysates.
Furthermore,
low
LpEV
concentrations
restored
TNF-α-induced
cellular
phenotypes,
resulting
increased
cell
proliferation
collagen
synthesis,
but
decreased
levels
(matrix
metalloproteinase
1,
interleukin
6,
8)
dermal
fibroblasts,
which
was
comparable
that
retinoic
acid,
representative
antiaging
compound.
validated
3D
model.
treatment
remarkably
epidermal
malformation,
abnormal
keratinocytes
basal
layer,
reduction
synthesis.
Additionally,
penetrated
reached
deepest
layer
within
24
h
when
overlaid
top
equivalent.
they
possessed
superior
antioxidant
capacity
compared
cell-derived
EVs.
Taken
together,
probiotic
be
attractive
substances
improving
inflammation-induced
disorders.
Foods,
Journal Year:
2024,
Volume and Issue:
13(22), P. 3529 - 3529
Published: Nov. 5, 2024
Obesity
is
a
pandemic
currently
affecting
the
world's
population
that
decreases
quality
of
life
and
promotes
development
chronic
non-communicable
diseases.
