Toxicological Safety Assessment of Heat‐Treated Lactiplantibacillus plantarum OLL2712 as a Food Ingredient DOI Creative Commons

Ryan M. Parente,

Takayuki Toshimitsu,

Youko Nakamoto

et al.

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Lactiplantibacillus plantarum is a Gram-positive, bacilli-shaped bacterium commonly found in fermented foods and the human gastrointestinal tract. Heat-treatment of L. OLL2712 prior to consumption has been have positive health effects. However, full toxicological evaluation heat-treated cells (heat-treated OLL2712) not conducted. In this regard, was evaluated for use as an ingredient food dietary supplements using panel tests including genotoxic subchronic studies. Heat-treated did show any genotoxicity based on vitro mammalian chromosomal aberration test vivo mouse micronucleus assay up 8.0 × 10

Language: Английский

Advancements in Lactiplantibacillus plantarum : probiotic characteristics, gene editing technologies and applications DOI Creative Commons
Zhiqi Zhang, Huifeng Niu,

Qiu Qu

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 2, 2025

The exploration of microorganisms in fermented products has become a pivotal area scientific research, primarily due to their widespread availability and profound potential improve human health. Among these, Lactiplantibacillus plantarum (formerly known as Lactobacillus plantarum) stands out versatile lactic acid bacterium, prevalent across diverse ecological niches. Its appeal extends beyond its well-documented probiotic benefits include the remarkable plasticity genome, which captivated both industrial stakeholders. Despite this interest, substantial challenges persist fully understanding harnessing L. plantarum. This review aims illuminate attributes plantarum, consolidate current advancements gene editing technologies, explore multifaceted applications wild-type genetically engineered strains.

Language: Английский

Citations

3
Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review DOI Open Access
Manuel Reiriz, Ana Isabel Beltrán-Velasco, Víctor Echeverry‐Alzate

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 391 - 391

Published: Jan. 22, 2025

Background/Objectives: This systematic review focused on collecting the most significant findings impact of administration Bifidobacterium infantis (or longum subps. infantis) and breve, alone, in conjunction, or combination with other strains, treatment neurodegenerative diseases including Alzheimer’s disease (AD) Parkinson’s (PD). These are characterized by progressive degeneration neurons, resulting a broad spectrum clinical manifestations. AD is typified decline cognitive abilities, while PD marked motor symptoms associated loss dopamine (DA). Methods: Five different databases, ScienceDirect, Scopus, Wiley, PubMed, Web Science (WoS), were reviewed studies screened for inclusion following criteria: (i) that specifically evaluated use infantis, subsp. breve as therapeutic intervention, either human animal models, context diseases; (ii) required to address one more pathologies examined this article, included, but not limited to, neurodegeneration, disease, oxidative stress; (iii) full text was accessible online; (iv) article written English. Results: The data suggest these probiotics have neuroprotective effects may delay progression. Conclusions: study provides updated insights into strains like PD, main limitation being number trials available.

Language: Английский

Citations

2
Can microbiota gut-brain axis reverse neurodegenerative disorders in human? DOI
Xingxing Yuan, Serge Yannick Ouédraogo,

Modou Lamin Jammeh

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102664 - 102664

Published: Jan. 1, 2025

Language: Английский

Citations

1
Gut–Brain Axis and Brain Microbiome Interactions from a Medical Perspective DOI Creative Commons
Borros Arneth

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 167 - 167

Published: Feb. 8, 2025

Background: The gut microbiome directly impacts brain health and activity, meaning the two are closely associated. This relationship suggests a link between microbial imbalances diseases such as Alzheimer’s, although multiple other contributing factors, genetics, also play part. Additionally, recent studies discovered that cerebrospinal fluid has some deoxyribonucleic acid (DNA), which can be interpreted to mean exists in too. vagus nerve central nervous immune systems responsible for connection microbiome. Aims Objectives: main aim of this systematic review is analyze existing research on gut–brain axis fill current knowledge gap. Materials Methods: A search was conducted PubMed database based set predefined MeSH terms. Results: After search, 2716 articles meeting parameters were found PubMed. list then downloaded analyzed according inclusion/exclusion criteria, 63 relevant papers selected. Discussion: Bacteria produce substances considered neuroactive. These compounds or indirectly affect function through axis. However, various gaps mechanisms involved need addressed first.

Language: Английский

Citations

1
The impact of gut microbiota on the occurrence, treatment, and prognosis of ischemic stroke DOI Creative Commons
Liying Chen, Xi Wang,

Shiqi Wang

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106836 - 106836

Published: Feb. 1, 2025

Ischemic stroke (IS) is a cerebrovascular disease that predominantly affects middle-aged and elderly populations, exhibiting high mortality disability rates. At present, the incidence of IS increasing annually, with notable trend towards younger affected individuals. Recent discoveries concerning "gut-brain axis" have established connection between gut brain. Numerous studies revealed intestinal microbes play crucial role in onset, progression, outcomes IS. They are involved entire pathophysiological process through mechanisms such as chronic inflammation, neural regulation, metabolic processes. Although numerous explored relationship microbiota, comprehensive analyses specific microbiota relatively scarce. Therefore, this paper provides an overview typical changes following investigates microorganisms context. Additionally, it presents analysis post-stroke microbiological therapy diet. The aim to identify potential microbial targets for therapeutic intervention, well highlight benefits therapies significance dietary management. Overall, seeks provide key strategies treatment management IS, advocating healthy diets health programs Meanwhile, may offer new perspective on future interdisciplinary development neurology, microbiology nutrition.

Language: Английский

Citations

1
Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review DOI Creative Commons
Constantin Munteanu, Anca‐Irina Galaction, Marius Turnea

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1062 - 1062

Published: Aug. 30, 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.

Language: Английский

Citations

8
In vitro evaluation of probiotic and antioxidant potential of Lacticaseibacillus paracasei ED25 DOI

Elanur Dasdemir,

Nazli Pinar Arslan, Serkan Örtücü

et al.

Biologia, Journal Year: 2024, Volume and Issue: 79(7), P. 2311 - 2325

Published: June 11, 2024

Language: Английский

Citations

5
Lactobacillaceae and Parkinson's disease: An apparent paradox DOI Creative Commons

Marieke ME van der Maden,

Marcel M. Verbeek, Milan Beckers

et al.

Journal of Parkinson s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Parkinson's disease (PD) is a neurodegenerative disorder predominantly known for its motor symptoms such as bradykinesia, rigidity and tremor, but the also increasingly recognized association with impaired gastrointestinal function. The composition of gut microbiome to be different in PD compared healthy individuals. One bacterial families increased abundance people Lactobacillaceae. Interestingly, opposite effects have been ascribed Lactobacillaceae PD. A number studies linked spp. worse function, premature degradation levodopa. However, other administration Lactobacillaceae-containing probiotics improved function reduced problems. In this narrative review, we investigate apparent paradox. key understanding appears lie specific species L. plantarum particular seemed show correlation symptoms, well reduction intestinal inflammation, whereas brevis, curvatus fermentum properties that might detrimental

Language: Английский

Citations

0
Proteomics and metabolomics elucidate the biosynthetic pathway of acid stress-induced exopolysaccharides and its impact on growth phenotypes in Lactiplantibacillus plantarum HMX2 DOI
Xinyu Yang, Zhijie Yang, Yanbo Wang

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 476, P. 143431 - 143431

Published: Feb. 17, 2025

Language: Английский

Citations

0
Targeting gut microbiota as a therapeutic approach for neurodegenerative diseases DOI Creative Commons
Tobiloba Samuel Olajide, Omamuyovwi M. Ijomone

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Abstract Recent evidence suggests a more important role of the gut microbiota in neurodegenerative diseases (NDDs) given its relationship through microbiota‐gut‐brain as an active communication system aiding maintaining homeostasis between brain and gut. This review focuses on how modulation can serves therapeutic strategy for NDDs, emphasizing neuroprotective effects probiotics. Probiotics are live microorganisms that confer health benefits, their interaction with gut‐microbiota influences neurogenesis, neurotransmitter regulation, neuroinflammation. advancements, including germ‐free animal models, fecal transplantation (FMT), diverse probiotic strains, have revealed underlying mechanisms linking to function. Notably, several Lactobacillus Bifidobacterium species been shown exert via upregulation neurotrophic factors such brain‐derived factor enhancing mitochondrial function reducing impacts oxidative stress. Interestingly, FMT has exhibited degree success overcoming cognitive impairment motor deficits preclinical studies clinical trials. However, further research is warranted explore potential humans. Overall, this highlights significant NDDs advocates gut‐targeted interventions innovative approaches mitigate these diseases.

Language: Английский

Citations

0