BMC Public Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Oct. 24, 2024
Particulate
matter
(PM),
including
the
major
risk
factor
for
lung
cancer
(LC),
greatly
impacts
human
health.
Although
numerous
studies
have
highlighted
spatiotemporal
patterns
and
PM-LC
associations,
these
not
been
well-reviewed.
Thus,
we
examined
epidemiological
linked
with
provided
concise,
up-to-date
data.
We
used
certain
keywords
to
review
articles
published
in
PubMed,
Web
of
Science,
Scopus,
Google
Scholar
until
30th
June
2024
identified
1474
research
articles.
then
filtered
based
on
our
criteria
ultimately
dropped
down
30
this
review.
Out
thirty
reviewed
relation,
twenty-four
focused
PM2.5,
four
PM10,
two
both,
indicating
that
approximately
80%
respondents
were
inclined
toward
fine
particles
their
health
impacts.
The
study
revealed
22
visualization,
12
exploration,
15
modeling
methods.
A
strong
positive
relationship
was
reported
between
LC
ranging
from
1.04
1.60
(95%
CI)
a
10
µg/m3
increase
PM2.5
exposure.
However,
compared
PM10
found
significantly
less
association.
Very
few
advanced
methods
examine
association
PM.
Advanced
analysis
techniques
should
be
employed
explore
specific
geographical
locations.
Further
utilize
approaches
link
PM
cancer.
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Sept. 13, 2023
Abstract
Cancer
is
a
complex
disease
with
many
contributing
factors,
and
researchers
have
gained
extensive
knowledge
that
has
helped
them
understand
the
diverse
varied
nature
of
cancer.
The
altered
patterns
DNA
methylation
found
in
numerous
types
cancer
imply
they
may
play
part
disease’s
progression.
human
condition
involves
dysregulation
methyltransferase
3
beta
(DNMT3B)
gene,
prominent
de
novo
methyltransferase,
its
abnormal
behavior
serves
as
an
indicator
for
tumor
prognosis
staging.
expression
non-coding
RNAs
(ncRNAs),
which
include
microRNAs
(miRNA),
long
(lncRNAs),
circular
(circRNAs),
critical
controlling
targeted
gene
protein
translation
their
correlates
onset
tumors.
NcRNAs
factor
influences
modulation
several
cellular
characteristics
cancerous
cells.
These
but
are
not
limited
to,
drug
responsiveness,
angiogenesis,
metastasis,
apoptosis,
proliferation,
properties
stem
cell.
reciprocal
regulation
ncRNAs
DNMT3B
can
act
synergy
to
influence
destiny
Thus,
avenue
advancing
prevention
treatment
inquiry
into
interplay
between
ncRNAs.
In
this
review,
we
present
comprehensive
overview
ncRNAs/DNMT3B
axis
pathogenesis.
This
brings
about
valuable
insights
intricate
mechanisms
tumorigenesis
provides
foundation
developing
effective
therapeutic
interventions.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(2), P. 161 - 161
Published: Feb. 19, 2024
Numerous
toxicological
studies
have
highlighted
the
association
between
urban
particulate
matter
(PM)
and
increased
respiratory
infections
lung
diseases.
The
adverse
impact
on
lungs
is
directly
linked
to
complex
composition
of
matter,
initiating
reactive
oxygen
species
(ROS)
production
consequent
lipid
peroxidation.
Excessive
ROS,
particularly
within
mitochondria,
can
destroy
subcellular
organelles
through
various
pathways.
In
this
study,
we
confirmed
induction
ferroptosis,
an
iron-dependent
cell
death,
upon
exposure
PM
using
RT-qPCR
signaling
pathway
analysis.
We
used
KRISS
CRM
109-02-004,
certified
reference
material
for
analysis
produced
by
Korea
Research
Institute
Standards
Science
(KRISS).
To
validate
that
ferroptosis
causes
endothelial
toxicity,
assessed
intracellular
mitochondrial
potential,
ROS
overproduction,
peroxidation,
specific
biomarkers.
Following
PM,
a
significant
increase
in
generation
decrease
potential
were
observed.
Furthermore,
it
induced
hallmarks
including
accumulation
loss
antioxidant
defenses,
cellular
iron
accumulation.
addition,
occurrence
oxidative
stress
as
key
feature
was
expression
levels
markers
such
NQO1,
CYP1B1,
FTH1,
SOD2,
NRF.
Finally,
observed,
xCT/SLC7A11,
TRIM16,
HMOX-1,
FTL,
CHAC1,
GPX4.
This
provides
evidence
elevated
induce
stress,
which
ultimately
triggers
ferroptosis.
conclusion,
our
results
show
CRM,
induces
production,
leading
subsequent
These
suggest
may
offer
strategies
treatment
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Abstract
Particulate
matter
(PM)
found
in
the
air
is
one
of
major
sources
pollution
and
air‐borne
diseases.
Therefore,
it
imperative
to
examine
elemental
concentration
distribution
PM
identify
pollutant
sources.
In
this
study,
has
demonstrated
capabilities
micro‐particle‐induced
X‐ray
emission
(micro‐PIXE)
spectroscopy
quantitative
analysis
samples
collected
from
Old
Delhi
outdoor
market
indoor
locations
Panjab
University
hostel
winter
months.
A
2‐million
electronvolts
energetic
scanning
proton
micro‐beam
(diameter
≈1
µm
2
)
used
micro‐PIXE
experiments
generating
high‐resolution
maps
different
regions
interest
(ROI).
Micro‐PIXE
along
with
GeoPIXE
provides
a
non‐destructive,
standard‐less,
ng/mg
level‐sensitive
tool
for
investigation
distributions
highlighting
pixels,
which
correlates
specific
ratios
between
elements
at
ROIs,
thereby
enabling
comprehensive
understanding
source
each
particulate.
Si,
Ca,
K
detected
suggest
soil
erosion
crop
burning,
while
high
S
levels
are
primarily
associated
coal
power
plants.
Additionally,
Sc,
Ti,
Cr,
Mn,
Zn
samples,
also
contained
trace
amounts
V,
Co,
Cu.
Organoid,
Journal Year:
2025,
Volume and Issue:
5, P. e2 - e2
Published: Feb. 25, 2025
Background:
Particulate
matter
(PM)
can
penetrate
deep
into
the
lungs,
leading
to
diseases
through
induction
of
hypoxia
and
inflammation.
The
hypoxia-inducible
factor-1α
(HIF-1α)
protein
is
well-established
as
a
key
factor
in
hypoxic
response,
PM
exposure
has
been
linked
induction.
To
develop
model
suitable
for
studying
PM-induced
hypoxia,
we
compared
expression
HIF-1α
between
conventional
2-dimensional
(2D)
cell
culture
3-dimensional
(3D)
model.Methods:
BEAS-2B
cells
were
cultured
2D
(using
96-well
plate)
3D
(utilizing
U-shaped
pillar
strip-based)
models
compare
cellular
responses
following
treatment.
Protein
levels
analyzed
using
Western
blotting.Results:
increased
both
time-
concentration-dependent
manner
treatment,
with
more
pronounced
robust
response
observed
model.
Furthermore,
quantitative
analysis
dye
staining
confirmed
that
exhibited
higher
level
after
model.Conclusion:
In
this
study,
treatment
was
pillar-based
A
distinct,
increase
These
results
highlight
suitability
investigating
hypoxia.
Marine Drugs,
Journal Year:
2025,
Volume and Issue:
23(3), P. 135 - 135
Published: March 20, 2025
Air
pollution-related
skin
damage
has
heightened
the
demand
for
natural
protective
agents.
Hizikia
fusiformis,
a
brown
seaweed
rich
in
fucoidan
and
bioactive
fatty
acids
(α-linolenic
acid,
eicosatetraenoic
palmitic
acid),
possesses
antioxidant
anti-inflammatory
properties.
This
study
investigated
effects
of
H.
fusiformis
ethanol
extract
(HFE)
against
particulate
matter
(PM)-induced
oxidative
stress,
inflammation,
apoptosis
human
keratinocytes.
Antioxidant
activity
was
assessed
using
DPPH
hydroxyl
radical
scavenging
assays,
while
PM-induced
cytotoxicity,
ROS
generation,
inflammatory
markers,
apoptotic
pathways
were
evaluated
WST-8
assay,
DCFH2-DA,
qPCR,
western
blotting,
Hoechst
staining.
HFE
significantly
reduced
levels,
enhanced
enzyme
activity,
mitigated
cytotoxicity.
These
mediated
by
acids,
which
modulated
(NF-κB
MAPK),
stabilized
membranes,
inhibited
(Bcl-2,
Bax,
caspase-3).
Collectively,
these
findings
highlight
HFE’s
potential
as
anti-pollution
skincare
ingredient,
supporting
further
vivo
studies
formulation
development.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(9), P. 1135 - 1135
Published: Sept. 8, 2024
Fine
particulate
matter
(PM2.5)
is
a
significant
cause
of
respiratory
diseases
and
associated
cellular
damage.
The
mechanisms
behind
this
damage
have
not
been
fully
explained.
This
study
investigated
two
types
(inflammation
pyroptosis)
induced
by
PM2.5,
focusing
on
their
relationship
with
organelles
(the
endoplasmic
reticulum
mitochondria).
Animal
models
demonstrated
that
PM2.5
induces
excessive
stress
(ER
stress),
which
lung
in
rats.
was
confirmed
pretreatment
an
ER
inhibitor
(4-Phenylbutyric
acid,
4-PBA).
We
found
that,
vitro,
the
intracellular
Ca2+
([Ca2+]i)
dysregulation
rat
alveolar
macrophages
stress.
Changes
mitochondria-associated
membranes
(MAMs)
result
abnormal
mitochondrial
function.
further
massive
expression
NLRP3
GSDMD-N,
detrimental
to
cell
survival.
In
conclusion,
our
findings
provide
valuable
insights
into
between
[Ca2+]i
dysregulation,
damage,
inflammation
pyroptosis
under
PM2.5-induced
conditions.
Their
interactions
ultimately
impact
health.
