One‐Step Synthesis of Metal Oxide Nanoparticles Using Cannabidiol: Characterisation and Cytotoxicity Assessment in Human Keratinocyte Cells DOI Creative Commons
Andrea Jess Josiah, Sreejarani Kesavan Pillai, Werner Cordier

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(8)

Published: Feb. 22, 2024

Abstract This research paper explores the field of nanobiotechnology, focusing on design, characterisation, and potential dermal applications metal oxide nanoparticles (MONPs). ZnO FeO NPs exhibit distinctive properties that are valuable in dermato‐cosmetic transdermal drug delivery. study investigates Cannabidiol (CBD) as a capping agent for MONPs synthesis. Employing microwave‐assisted techniques, were synthesised using either CBD or polyvinylpyrrolidone (PVP) agents. The TEM, SEM, FTIR, XRD characterisation results confirmed successful formation CBD‐capped exhibiting an average particle size 90 76 nm, respectively. cytotoxicity was evaluated HaCaT cells over concentration range 100 to 6.25 μg/mL, which revealed exerted cytotoxic effect (IC 50 85.34±1.17 μg/mL). In contrast, PVP‐capped exhibited negligible >100 TEM analysis noticeable structural alteration supplemented cell culture medium, could contribute enhanced NP uptake, thereby explaining more pronounced NPs. Therefore, disparity responses can be attributed protein coating adhering surface biological medium.

Language: Английский

The Potential Role of Cannabidiol in Cosmetic Dermatology: A Literature Review DOI Creative Commons
Ai Kuzumi, Asako Yoshizaki‐Ogawa, Takemichi Fukasawa

et al.

American Journal of Clinical Dermatology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

Language: Английский

Citations

5
Research progress in the management of vascular disease with cannabidiol: a review DOI Creative Commons
Yilong Guo, Wei Ren, Jianqing Deng

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 3, 2024

Abstract The morbidity and mortality rates associated with vascular disease (VD) have been gradually increasing. Currently, the most common treatment for VD is surgery, progress in drug therapy remaining slow. Cannabidiol (CBD) a natural extract of Cannabis sativa L. sedative, analgesic, nonaddictive properties. CBD binds to 56 cardiovascular-related receptors exerts extensive regulatory effects on cardiovascular system, making it potential pharmacological agent management VD. However, studies focused neurological cardiac diseases, research still rare. In this review, we summarize currently available data VD, addressing four aspects: major molecular targets management, pharmacokinetic properties, therapeutic VDs, side effects. findings indicate that has anti-anxiety, anti-oxidation, anti-inflammatory properties can inhibit abnormal proliferation apoptosis smooth muscle endothelial cells; these suggest as atherosclerosis, stress-induced hypertension, diabetes-related vasculopathy, ischemia-reperfusion injury, damage caused by smoking alcohol abuse. This study provides theoretical basis further

Language: Английский

Citations

4
Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/SIRT3/Nrf2 Axis DOI Open Access
Islauddin Khan, Sukhmandeep Kaur, Arun K. Rishi

et al.

Published: April 28, 2024

Background In this study we investigated in detail the role of cannabidiol (CBD), Beta-caryophyllene (BC), or their combinations diabetic peripheral neuropathy (DN). The key factors that contribute to DN include mitochondrial dysfunction, inflammation, and oxidative stress. Methods Briefly, Streptozotocin (STZ) (55 mg/kg) was injected intraperitoneally induce Sprague Dawley rats performed procedures including Randall Sellito Calipers, Von Frey Aesthesiometer, hot plate, cold plate methods determine mechanical thermal hyperalgesia vivo. blood flow nerves assessed by using Laser Doppler device. Schwann cells were exposed high glucose (HG) at a dose 30 mM hyperglycemia DCFDA, JC1 & Mitosox staining done membrane potential, reactive oxygen species superoxides in-vitro. administered i.p with BC (30mg/kg), CBD (15mg/kg), combination while treated 3.65 µM CBD, 75 BC, assess amelioration. Results Our results revealed exposure diminished HG-induced cells, part, through reducing superoxides. Further, treatment in-vivo could prevent deterioration quality control system promoting autophagy biogenesis improving flow. treatments also reduced pain hypersensitivity allodynia increased antioxidant anti-inflammatory action rats. These vivo effects attributed significant upregulation AMPK, SIRT3, Nrf2, PINK1, PARKIN, LC3B, Beclin1 TFAM functions downregulation NLRP3 inflammasome, NFκB, COX2 p62 activity noted as determined western blotting. Conclusion present studies demonstrated STZ HG induced nitrosative stress play crucial pathogenesis neuropathy. We find, for first time, ameliorate via modulating system.

Language: Английский

Citations

4
Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis DOI Creative Commons
Islauddin Khan, Sukhmandeep Kaur, Arun K. Rishi

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1442 - 1442

Published: June 28, 2024

In this study, we investigated in detail the role of cannabidiol (CBD), beta-caryophyllene (BC), or their combinations diabetic peripheral neuropathy (DN). The key factors that contribute to DN include mitochondrial dysfunction, inflammation, and oxidative stress.

Language: Английский

Citations

4
CBD for pets: navigating quality assurance, safety standards, and marketing strategies DOI Creative Commons

Hannah Rideout,

A. J. C. Cook, Anthony D. Whetton

et al.

Journal of Cannabis Research, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 23, 2025

Abstract As the human cannabinoid (CBD) market grows, there is an inevitable transfer of same or similar products into veterinary sector. Advances in medicine and care companion animals has led to extended life expectancy consequently, increased incidence age-related chronic conditions that compromise quality life. CBD may alleviate these conditions. Research for animal species on rise, however, we found are no licensed available due a lack appropriate testing and/or data. Here outline data show regulatory, safety considerations around needs further consideration this encompasses many currently market. Changes regulations research assurance paramount distribution safe applicable animals.

Language: Английский

Citations

0
A comprehensive molecular analysis of cannabidiol: From solid state to antioxidant potential DOI
Antônio S. N. Aguiar,

Cristiano M. Veloso,

Yuri B.R. Tejota

et al.

Computational and Theoretical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 114890 - 114890

Published: Sept. 1, 2024

Language: Английский

Citations

3
Protective Actions of Cannabidiol on Aging-Related Inflammation, Oxidative Stress and Apoptosis Alterations in Liver and Lung of Long Evans Rats DOI Creative Commons
Lisa Rancán, Beatriz Linillos-Pradillo,

J. D. Centeno

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(10), P. 1837 - 1837

Published: Oct. 9, 2023

Background: Aging is characterised by the progressive accumulation of oxidative damage which leads to inflammation and apoptosis in cells. This affects all tissues body causing deterioration several organs. Previous studies observed that cannabidiol (CBD) could extend lifespan health span its antioxidant, anti-inflammatory autophagy properties. However, research on anti-aging effect CBD still beginning stages. study aimed investigate role prevention age-related alterations liver lung using a murine model. Methods: 15-month-old Long Evans rats were treated with 10 mg/kg b.w./day for weeks compared animals same age as old control 2-month-old young control. Gene and/or protein expressions, RT-qPCR Western blotting, respectively, assessed terms molecules related stress (GST, GPx, GR HO-1d), (NFκB, IL-1β TNF-α) (BAX, Bcl-2, AIF, CASP-1). In addition, MDA MPO levels measured colorimetric assay. Results analysed ANOVA followed Tukey–Kramer test, considering statistically significant p < 0.05. Results: GST, GPx expressions significantly reduced (p 0.01) samples from ones treatment was able revert it. A increase relation markers (MDA proinflammatory TNF-α), proapoptotic AIF CASP-1), while no antiapoptotic (Bcl-2). All these changes more noticeable liver, seemed be less affected. almost parameters, caused restoring those group animals. Conclusions: Chronic showed beneficial effects reducing inflammatory, apoptotic mediators, hence cell associated three processes inherent aging.

Language: Английский

Citations

7
Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds DOI Creative Commons
Anna Rybarczyk, Aleksandra Majchrzak‐Celińska, Violetta Krajka‐Kuźniak

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(12), P. 2052 - 2052

Published: Nov. 28, 2023

The development and progression of cancer are associated with the dysregulation multiple pathways involved in cell proliferation survival, as well dysfunction redox balance, immune response, inflammation. master antioxidant pathway, known nuclear factor erythroid 2-related 2 (Nrf2) regulates cellular defense against oxidative stress inflammation, making it a promising prevention treatment target. Cannabinoids have demonstrated anti-tumor anti-inflammatory properties, affecting signaling pathways, including Nrf2. Increased following exposure to anti-cancer therapy prompts cells activate mechanisms. This indicates dual effect Nrf2 cells-influencing apoptotic processes protecting toxicity therapy. Therefore, understanding complex role cannabinoids modulating might shed light on its potential implementation an support. In this review, we aim highlight impact Nrf2-related factors, focus treatment. Additionally, presented results several research studies that combined cannabidiol (CBD) other compounds targeting Further should be directed toward exploring effects context

Language: Английский

Citations

6
Cannabidiol, a Strategy in Aging to Improve Redox State and Immunity in Male Rats DOI Open Access

Mónica De la Fuente,

Noelia Joyera,

Judith Félix

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12288 - 12288

Published: Nov. 15, 2024

Aging is characterized by oxidative stress and immune function impairment, associated with increased morbidity. Cannabidiol (CBD) has anti-oxidant properties, but its role in aging been scarcely studied. This work aims to test the effect of CBD on redox state immunity during rats. In this study, 15-month-old male Long Evans rats received 10 mg/kg b.w/day their diet for weeks were compared same-age control 2-month-old serving as a young group, both following standard diet. After treatment, they sacrificed, spleen, thymus, total blood cells collected. Redox parameters such glutathione reductase peroxidase activities, reduced (GSH) oxidized (GSSG) concentration, GSSG/GSH ratio, lipid peroxidation evaluated. Moreover, functions (chemotaxis, natural killer activity, lymphoproliferation) analyzed spleen. Results show that exhibited immunosenescence However, CBD-treated animals showed higher defenses, lower oxidants cells, better spleen than corresponding age-matched controls. Therefore, administration neutralizes improves immunity, suggesting it strategy achieving healthy aging.

Language: Английский

Citations

2
One‐Step Synthesis of Metal Oxide Nanoparticles Using Cannabidiol: Characterisation and Cytotoxicity Assessment in Human Keratinocyte Cells DOI Creative Commons
Andrea Jess Josiah, Sreejarani Kesavan Pillai, Werner Cordier

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(8)

Published: Feb. 22, 2024

Abstract This research paper explores the field of nanobiotechnology, focusing on design, characterisation, and potential dermal applications metal oxide nanoparticles (MONPs). ZnO FeO NPs exhibit distinctive properties that are valuable in dermato‐cosmetic transdermal drug delivery. study investigates Cannabidiol (CBD) as a capping agent for MONPs synthesis. Employing microwave‐assisted techniques, were synthesised using either CBD or polyvinylpyrrolidone (PVP) agents. The TEM, SEM, FTIR, XRD characterisation results confirmed successful formation CBD‐capped exhibiting an average particle size 90 76 nm, respectively. cytotoxicity was evaluated HaCaT cells over concentration range 100 to 6.25 μg/mL, which revealed exerted cytotoxic effect (IC 50 85.34±1.17 μg/mL). In contrast, PVP‐capped exhibited negligible >100 TEM analysis noticeable structural alteration supplemented cell culture medium, could contribute enhanced NP uptake, thereby explaining more pronounced NPs. Therefore, disparity responses can be attributed protein coating adhering surface biological medium.

Language: Английский

Citations

0