International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4735 - 4735
Published: April 26, 2024
Cardiac
disorders
in
cancer
patients
pose
significant
challenges
to
disease
prognosis.
While
it
has
been
established
that
these
are
linked
cells,
the
precise
underlying
mechanisms
remain
elusive.
In
this
study,
we
investigated
impact
of
cancerous
ascites
from
rat
colonic
carcinoma
cell
line
RCN9
on
H9c2
cardiomyoblast
cells.
We
found
reduced
mitochondrial
volume,
increased
oxidative
stress,
and
decreased
membrane
potential
leading
apoptosis
autophagy.
Although
fluid
contained
a
substantial
amount
high-mobility
group
box-1
(HMGB1),
observed
neutralizing
HMGB1
with
specific
antibody
mitigated
damage
inflicted
myocardial
Our
mechanistic
investigations
revealed
activated
both
nuclear
factor
κB
phosphoinositide
3-kinases-AKT
signals
through
receptors,
namely
receptor
for
advanced
glycation
end
products
toll-like
receptor-4,
thereby
promoting
contrast,
treatment
berberine
(BBR)
induced
expression
miR-181c-5p
miR-340-5p
while
suppressing
Furthermore,
BBR
cardiomyocytes,
consequently
mitigating
HMGB1-induced
damage.
validated
protective
effects
cachectic
model.
These
findings
underscore
strong
association
between
cachexia,
highlighting
as
promising
therapeutic
agent
protection
suppression
modulation
signaling
system.
Food Reviews International,
Journal Year:
2023,
Volume and Issue:
40(9), P. 2539 - 2579
Published: Nov. 12, 2023
Although
sarcopenia
has
been
a
serious
public
health
concern
worldwide
in
recent
years,
its
effective
prevention
and
intervention
measures
are
still
lacking.
The
latest
research
found
that
autophagy
dysfunction
is
an
essential
mechanism
the
pathogenesis
of
sarcopenia.
And
meanwhile,
increasing
studies
have
shown
phytonutrients
consumption
positively
correlated
with
maintenance
skeletal
muscle
mass
strength,
which
involves
regulation
pathway.
However,
due
to
opposite
environmental-dependent
effect
sarcopenia,
targeting
by
as
treatment
sometimes
considered
controversial.
Thus,
this
review,
based
on
illustration
relationship
between
complex
changes
ameliorating
regulating
reviewed
emphasis,
possible
underlying
mechanisms
systematically
summarized.
Despite
some
controversies,
most
current
support
idea
maintaining
basal
functional
contributes
Several
exhibit
substantial
beneficial
effects
autophagy,
polyphenols
(especially
catechins
urolithin
A)
be
potentially
clinical
relevance.
Hence,
development
promising
approach
complications.
The Journal of Cardiovascular Aging,
Journal Year:
2023,
Volume and Issue:
4(1)
Published: Dec. 27, 2023
The
loss
of
skeletal
muscle,
also
known
as
sarcopenia,
is
an
aging-associated
muscle
disorder
that
disproportionately
present
in
heart
failure
(HF)
patients.
HF
patients
with
sarcopenia
have
poor
outcomes
compared
to
the
overall
patient
population.
prevalence
only
expected
grow
global
population
ages,
and
novel
treatment
strategies
are
needed
improve
this
cohort.
Multiple
mechanistic
pathways
emerged
may
explain
increased
population,
a
better
understanding
these
lead
development
therapies
prevent
loss.
This
review
article
aims
explore
molecular
mechanisms
linking
HF,
discuss
aimed
at
addressing
such
signals.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4735 - 4735
Published: April 26, 2024
Cardiac
disorders
in
cancer
patients
pose
significant
challenges
to
disease
prognosis.
While
it
has
been
established
that
these
are
linked
cells,
the
precise
underlying
mechanisms
remain
elusive.
In
this
study,
we
investigated
impact
of
cancerous
ascites
from
rat
colonic
carcinoma
cell
line
RCN9
on
H9c2
cardiomyoblast
cells.
We
found
reduced
mitochondrial
volume,
increased
oxidative
stress,
and
decreased
membrane
potential
leading
apoptosis
autophagy.
Although
fluid
contained
a
substantial
amount
high-mobility
group
box-1
(HMGB1),
observed
neutralizing
HMGB1
with
specific
antibody
mitigated
damage
inflicted
myocardial
Our
mechanistic
investigations
revealed
activated
both
nuclear
factor
κB
phosphoinositide
3-kinases-AKT
signals
through
receptors,
namely
receptor
for
advanced
glycation
end
products
toll-like
receptor-4,
thereby
promoting
contrast,
treatment
berberine
(BBR)
induced
expression
miR-181c-5p
miR-340-5p
while
suppressing
Furthermore,
BBR
cardiomyocytes,
consequently
mitigating
HMGB1-induced
damage.
validated
protective
effects
cachectic
model.
These
findings
underscore
strong
association
between
cachexia,
highlighting
as
promising
therapeutic
agent
protection
suppression
modulation
signaling
system.
