Exploring Bioactive Phytomedicines for Advancing Pulmonary Infection Management: Insights and Future Prospects DOI Creative Commons

Joyce Siaw Syuen Ho,

Teh Li Ping,

Keshav Raj Paudel

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Pulmonary infections have a profound influence on global mortality rates. Medicinal plants offer promising approach to address this challenge, providing nontoxic alternatives with higher levels of public acceptance and compliance, particularly in regions where access conventional medications or diagnostic resources may be limited. Understanding the pathophysiology viruses bacteria enables researchers identify biomarkers essential for triggering diseases. This knowledge allows discovery biological molecules capable either preventing alleviating symptoms associated these infections. In review, medicinal that an effect COVID-19, influenza A, bacterial viral pneumonia, tuberculosis are discussed. Drug delivery has been briefly discussed as well. It examines bioactive constituents synthesizes findings from vitro, vivo, clinical studies conducted over past decade. conclusion, many can used treat pulmonary infections, but further in-depth needed most current only at preliminary stages. Extensive investigation warranted fully elucidate their mechanisms action optimize use practice.

Language: Английский

Advances in Modern Medical Research on the Hematopoietic Effect of Qi and Blood Replenishing Drugs DOI

爽爽 段

Medical Diagnosis, Journal Year: 2025, Volume and Issue: 15(01), P. 123 - 133

Published: Jan. 1, 2025

Language: Английский

Citations

0
ZIF-8-Derived Nanozyme Loaded with Botanical Fungicides as an Eco-Friendly Nanopesticide for Microenvironment-Enhanced Synergistic Control of Ginseng Seedling Blight DOI
Jing Yu, Jialong He,

Y. N. Liu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

In this study, we successfully fabricated an eco-friendly nanopesticide with synergistic antifungal efficacy by loading the botanical fungicide osthole (OS) into ZIF-8-derived nanozymes (ZnSA) for microenvironment-enhanced control of ginseng seedling blight. The (OS@ZnSA) exhibited significant photostability and storage stability. Compared OS technique concentrate, inhibitory effect on Rhizoctonia solani was increased 28%. Plant experiments revealed that OS@ZnSA not only promoted growth seedlings but also markedly enhanced expression its defense enzymes. Safety evaluation showed had no soil microbial community, seed germination, human immortalized epidermal cells (HaCaT), demonstrating favorable biosafety profile. Overall, nanopesticides would provide a new perspective plant disease.

Language: Английский

Citations

0
Low-Medium Polarity Ginsenosides from Wild Ginseng Improves Immunity by Activating the AhR/MAPK Pathway through Tryptophan Metabolism Driven by Gut Microbiota DOI
Meiyu Zhang, Li‐Ting Ma, Jing Luo

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(47), P. 26142 - 26154

Published: Nov. 15, 2024

The gut microbiota contribute significantly to the immune system. Low-medium polarity ginsenosides from wild ginseng (LWG) have potential immunomodulatory effects. However, how LWG regulates enhance immunity remains unclear. To explore interaction between microbes and metabolites mediating LWG's effects, this study examined impact on splenocytes CTX-induced immunosuppressed mice. Metabolomic metagenomic analyses were conducted in vivo mechanism by which immunity.

Language: Английский

Citations

1
Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19 DOI Creative Commons
Fangyi Zhao, Kai Zhang, Hongyu Chen

et al.

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 32(1), P. 229 - 247

Published: Nov. 27, 2023

Language: Английский

Citations

2
Ginseng Soluble Dietary Fiber Enhances Spermatogenic Potential in Obese Mice via the MAPK Signaling Pathway DOI Creative Commons

Yue Zhang,

Yang Yu,

Chen Bai

et al.

Journal of Food Biochemistry, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Objectives . To investigate the effects of ginseng soluble dietary fiber (GSDF) on spermatogenic potential in high‐fat diet (HFD)‐induced obese mice. Method C57BL/6 mice were fed an HFD for 60 days, and GSDF was administered by gastric gavage. The divided into control, HFD, (high, medium, low), positive (metformin MH) groups. During this period, changes body weight recorded. Various organ indices measured 24 h after last dose. Sperm quality vas deferens epididymis tail determined using fully automated analyzers. Serum levels three lipids, cytokines, hormones detected ELISA. Pathological testicular tissue epididymal fat observed H&E immunofluorescence staining superoxide dismutase (SOD) 4‐hydroxynonenal (4‐HNE). Changes MAPK pathway proteins cells western blotting. Result intervention significantly reduced weight, renal index, white mice, while increasing index. serum total cholesterol (TC), triglyceride (TG), low‐density lipoprotein (LDL‐C) compared to group, thereby improving hyperlipidemia. Simultaneously, cytokine IL‐4 level increased, IL‐6 reduced, testosterone (T) hormone follicle‐stimulating (FSH) luteinizing (LH) GSDF‐treated viability, survival rate, density spermatozoa treated groups improved. Testicular interstitial cell vacuolization collagen fibrosis improved, spermatogonia aligned, hypertrophy suppressed. In treatment SOD increased significantly, whereas 4‐HNE decreased, with most evident effect medium‐dose group. ameliorated metabolic disorders regulating p‐JNK/p‐p38MAPK pathway. Conclusion signaling Thus, may be effective lipid‐lowering agent reproductive

Language: Английский

Citations

0
Exploring Bioactive Phytomedicines for Advancing Pulmonary Infection Management: Insights and Future Prospects DOI Creative Commons

Joyce Siaw Syuen Ho,

Teh Li Ping,

Keshav Raj Paudel

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Pulmonary infections have a profound influence on global mortality rates. Medicinal plants offer promising approach to address this challenge, providing nontoxic alternatives with higher levels of public acceptance and compliance, particularly in regions where access conventional medications or diagnostic resources may be limited. Understanding the pathophysiology viruses bacteria enables researchers identify biomarkers essential for triggering diseases. This knowledge allows discovery biological molecules capable either preventing alleviating symptoms associated these infections. In review, medicinal that an effect COVID-19, influenza A, bacterial viral pneumonia, tuberculosis are discussed. Drug delivery has been briefly discussed as well. It examines bioactive constituents synthesizes findings from vitro, vivo, clinical studies conducted over past decade. conclusion, many can used treat pulmonary infections, but further in-depth needed most current only at preliminary stages. Extensive investigation warranted fully elucidate their mechanisms action optimize use practice.

Language: Английский

Citations

0