Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Dec. 5, 2024
Stomach cancer is considered the fifth most common worldwide. This study utilized bibliometric analysis to construct a visualization map of relationship between stomach and exosomes, aiming reveal research trends emerging themes, provide direction for future research.
Language: Английский
Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217116 - 217116
Published: July 14, 2024
Language: Английский
Citations
8
BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)
Published: Feb. 21, 2024
Abstract Background The benefit of adding Zolbetuximab to the treatment in patients with Claudin-18 isoform 2 (CLDN18.2)-positive, human epidermal growth factor receptor 2-negative, locally advanced unresectable or metastatic gastric gastro-oesophageal junction adenocarcinoma (GC/GEJ) is not yet fully elucidated. Methods We searched PubMed, Embase and Cochrane databases for randomized controlled trials (RCTs) that investigated plus chemotherapy versus alone GC GEJ adenocarcinoma. computed hazard-ratios (HRs) odds-ratios (ORs) binary endpoints, 95% confidence intervals (CIs). Results Three studies 1,233 were included. Comparing alone, progression-free survival (PFS) rate (HR 0.64; CI 0.49–0.84; p < 0.01) overall (OS) 0.72; 0.62–0.83; significant favor group. Regarding effectiveness, Objective Response Rate (ORR) was (OR 1.15; 0.87–1.53; = 0.34). Conclusions In this comprehensive systematic review meta-analysis RCTs, incorporation alongside offers a promising prospect reshaping established paradigms diagnosed CLDN18.2-positive GC/GEJ cancer.
Language: Английский
Citations
7
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 31, 2024
P66Shc and Rac1 proteins are responsible for tumor-associated inflammation, particularly in brain tumors characterized by elevated oxidative stress increased reactive oxygen species (ROS) production. Quercetin, a natural polyphenolic flavonoid, is well-known redox modulator with anticancer properties. It has the capacity to cross blood–brain barrier and, thus, could be possible drug against tumors. In this study, we explored effect of quercetin on Rac1/p66Shc-mediated tumor cell which principal pathway generation ROS cells. Glioma cells transfected Rac1, p66Shc, or both were treated varying concentrations different time points. Quercetin significantly reduced viability migration an ROS-dependent manner concomitant inhibition Rac1/p66Shc expression production naïve Rac1/p66Shc-transfected lines, suggestive preventing activation. Through molecular docking simulations, observed that showed best binding compared other known inhibitors specifically blocked GTP-binding site A-loop prevent GTP We conclude exerts its effects via modulation Rac1-p66Shc signaling inhibiting activation, thus restraining growth.
Language: Английский
Citations
6
Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)
Published: Dec. 24, 2024
Abstract Gastric cancer (GC) represents a prevalent malignancy globally, often diagnosed at advanced stages owing to subtle early symptoms, resulting in poor prognosis. Exosomes are extracellular nano-sized vesicles and secreted by various cells. Mounting evidence indicates that exosomes contain wide range of molecules, such as DNA, RNA, lipids, proteins, play crucial roles multiple cancers including GC. Recently, with the rapid development mass spectrometry-based detection technology, researchers have paid increasing attention exosomal cargo proteins. In this review, we discussed origin diagnostic prognostic proteins Moreover, summarized biological functions GC processes, proliferation, metastasis, drug resistance, stemness, immune response, angiogenesis, traditional Chinese medicine therapy. summary, review synthesizes current advancements associated GC, offering insights could pave way for novel therapeutic strategies foreseeable future.
Language: Английский
Citations
5
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)
Published: March 6, 2025
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 16, 2025
Cisplatin chemotherapy is an important treatment for advanced ovarian cancer (OC). However, the development of cisplatin resistance greatly limits survival time OC patients. Endothelial cell-specific molecule 1 (ESM1) has been found to be proto-oncogene promoting OC, but its mediating remains unknown. We used quantitative polymerase chain reaction (qPCR) measure transcription levels ESM1, Growth arrest specific transcript 5 (GAS5), miR-23a-3p, and Phosphatase And Tensin Homolog (PTEN). A double luciferase reporter gene assay confirmed direct binding GAS5 miR-23a-3p PTEN mRNA. The effects GAS5, on were tested with Half Maximal Inhibitory Concentration (IC50) assay. Flow cytometry was assess cisplatin-induced apoptosis. Changes in apoptosis-related proteins PI3K/AKT-related analyzed western blot (WB). ESM1 inhibits increases miR-23a-3p. promote resistance. sensitivity cells. Moreover, main molecular mechanism ESM1/GAS5/miR-23a-3p/PTEN/PI3K/Akt signaling axis. promotes by activating Phosphoinositide-3-Kinase (PI3K)/AKT Serine/Threonine Kinase (Akt) pathway through GAS5/miR-23a-3p/PTEN This suggests that prescriptive regulates key downstream mechanisms via non-coding RNA can before neoadjuvant initiated.
Language: Английский
Citations
0
Cancer Gene Therapy, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Language: Английский
Citations
0
European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 290, P. 117543 - 117543
Published: March 30, 2025
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 13, 2025
Platinum was the first drug with proven activity against gastric cancer (GC), combination fluoropyrimidine is standard first-line systemic therapy for patients of GC. However, a major cause treatment failure still existence resistance. The purpose this study to identify and validate platinum-related genes in GC construct multi-gene joint signature predicting prognosis patients. Based on 326 from GeneCards, GO KEGG analysis were applied differentially expressed GC, UniCox regression used select effective Lasso-Cox utilized model. Stratified analysis, CNV landscape, TMB MSI status, HLA gene expression, GSEA GSVA immune activities, immunotherapy sensitivities evaluated resistant high low groups. Drug cell lines, PDO PDX models signature. 140 involved many processes pathways enriched platinum resistance cancer. screened out 21 conducted scoring indicated that score had good predictive value subgroups divided by T-stage, age race. changes more occurred score-high group, most model negatively correlated TMB, expression. group significantly higher, within mast cell, regulatory T dendritic infiltrated in. In vitro vivo showed varying degrees upregulation under CDDP chemotherapy pressure. gene-signature developed predict response It worthwhile further evaluate molecular biology clinical applications
Language: Английский
Citations
0
European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 274, P. 116528 - 116528
Published: May 23, 2024
Herein, we present a comprehensive review focusing on synthetic strategies, detailed structural analysis, and anticancer activity investigations of complexes following the general formula [L
Language: Английский
Citations
3