Journal of Sports Science and Nutrition,
Journal Year:
2021,
Volume and Issue:
2(2), P. 69 - 71
Published: July 1, 2021
Football
is
an
exceptional
avenue
for
achieving
and
maintaining
physical
fitness
due
to
its
dynamic
multifaceted
nature.
The
sport's
demanding
requirements,
such
as
continuous
running,
sprinting,
quick
changes
in
direction,
make
it
excellent
cardiovascular
workout
that
enhances
endurance
heart
health.
Additionally,
football
engages
various
muscle
groups
contributing
overall
strength
development
the
lower
body,
core
upper
body.
emphasis
on
speed,
agility
reaction
time
evident
sharp
turns,
rapid
accelerations
stretching
movements
involved.
also
serves
effective
means
of
speed
training
with
players
regularly
executing
sprints
maneuvers
during
matches.
idea
study
was
find
out
enhancing
components
inter
collegiate
men
through
based
program.
To
achieve
purpose
forty
(N-40)
were
randomly
selected
from
Government
Engineering
College
Thrissur
they
divided
into
two
equal
(n-15)
namely
experimental
control
group,
their
age
ranged
between
18
25year.
Speed
assessed
by
standard
tests
(speed
-50m
Dash
4*10m
shuttle
run).
Experimental
group
undergone
a
period
twelve
weeks.
results
revealed
there
significant
improvement
found
systematic
training.
Current Topics in Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
24(19), P. 1683 - 1698
Published: April 27, 2024
:
Alzheimer's
disease
(AD)
is
the
most
prevalent
form
of
neurodegenerative
disorder
(ND),
affecting
more
than
44
million
individuals
globally
as
2023.
It
characterized
by
cognitive
dysfunction
and
an
inability
to
perform
daily
activities.
The
progression
AD
associated
with
accumulation
amyloid
beta
(Aβ),
formation
neurofibrillary
tangles
(NFT),
increased
oxidative
stress,
neuroinflammation,
mitochondrial
dysfunction,
endoplasmic
reticulum
stress.
Presently,
various
phytomedicines
their
bioactive
compounds
have
been
identified
for
neuroprotective
effects
in
reducing
alleviating
mitigating
Aβ
acetylcholinesterase
enzymes
hippocampus
cerebral
cortex
regions
brain.
However,
despite
demonstrating
promising
anti-Alzheimer's
effects,
clinical
utilization
phytoconstituents
remains
limited
scope.
key
factor
contributing
this
limitation
challenges
inherent
traditional
drug
delivery
systems,
which
impede
effectiveness
efficiency.
These
difficulties
encompass
insufficient
targeting,
restricted
solubility
stability,
brief
duration
action,
a
lack
control
over
release.
Consequently,
these
constraints
result
diminished
bioavailability
permeability
across
blood-brain
barrier
(BBB).
In
response
challenges,
novel
systems
(NDDS)
founded
on
nanoformulations
emerged
hopeful
strategy
augment
BBB
poor
solubility.
Among
nanoemulsion
(NE)
extensively
investigated
potential
targeting
AD.
NE
offers
several
advantages,
such
ease
preparation,
high
loading,
stability.
Due
nanosize
droplets,
also
improves
gut
leading
enhanced
systemic
circulation
Various
studies
reported
testing
NE-based
bioactives
different
animal
species,
including
transgenic,
Wistar,
Sprague-Dawley
(SD)
rats,
well
mice.
transgenic
mice
are
commonly
employed
research
analyze
Aβ.
review,
aspects
role
phytoconstituents,
conventional
delivery,
need
NDDS,
particularly
NE,
discussed.
involving
phytoconstituent-based
treatment
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
Delving
into
the
intricate
role
of
phytonutrients
is
paramount
to
effectively
preventing
and
treating
chronic
diseases.
Phytonutrients
are
"plant-based
nutrients"
that
positively
affect
human
health.
perform
primary
therapeutic
functions
in
management
treatment
various
It
reported
different
types
pathogenesis
occur
due
excessive
production
oxidants
(reactive
nitrogen
species
reactive
oxygen
species).
The
literature
shows
a
higher
intake
fruits,
vegetables,
other
plant-based
food
inversely
related
Due
many
(antioxidants)
medicinal
plants,
they
considered
major
agents
for
main
purpose
this
review
summarize
involved
Fourteen
discussed
review,
such
as
polyphenols,
anthocyanin,
resveratrol,
phytosterol
(stigmasterol),
flavonoids,
isoflavonoids,
limonoids,
terpenoids,
carotenoids,
lycopene,
quercetin,
phytoestrogens,
glucosinolates,
probiotics,
which
well-known
their
beneficial
effects
on
body
pathological
conditions.
concluded
play
prevention
diabetes
mellitus,
obesity,
hypertension,
cardiovascular
disorders,
cancers,
neurological
age-related
diseases,
inflammatory
disorders
also
biological
activities.
Neuroinflammation
is
a
key
risk
factor
for
cognitive
impairment,
and
microglia
are
the
main
drivers.
Metformin
has
been
shown
to
suppress
inflammation
reduce
microglial
activation,
protecting
neurons
from
damage.
However,
its
clinical
efficacy
limited
by
low
bioavailability
metabolic
challenges,
especially
in
terms
of
precise
delivery
specific
targets.
To
overcome
this
problem,
we
developed
biomimetic
nanoparticles
(MePN@BM)
enhance
targeted
metformin.
Through
homologous
targeting,
efficiency
drugs
inflammatory
site
Parkinson's
disease
was
enhanced
improve
therapeutic
effect.
The
results
showed
that
MePN@BM
effectively
delivers
metformin
brain,
promotes
autophagy,
restores
mitochondrial
membrane
potential,
reduces
oxidative
stress.
In
(PD)
mouse
model,
improved
motor
function,
repaired
dopaminergic
neurons,
cleared
α-synuclein
aggregates.
Notably,
transcriptome
analysis
revealed
enriched
inflammation-related
pathways,
immunofluorescence
PD
mice
treated
with
had
higher
levels
anti-inflammatory
factors
lower
pro-inflammatory
factors.
Therefore,
it
provides
promising
strategy
treatment
inflammation-mediated
dysfunction.
BMC Complementary Medicine and Therapies,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 22, 2025
Cigarette
smoke
comprises
nicotine,
reactive
oxygen
species
(ROS),
and
carcinogens,
which
can
induce
oxidative
stress
inflammation,
leading
to
disruption
of
the
blood-brain
barrier.
This
study
utilized
cigarette
extract
(CSE)
in
an
vitro
model
barrier
(BBB).
Sesamol
is
a
phenolic
compound
derived
from
Sesamum
indicum
L.
Its
potential
reduce
inflammation
provide
protection
was
also
examined.
As
result
study,
it
found
that
CSE
significantly
increases
permeability
by
degrading
BBB,
whereas
protective
effect
observed
sesamol-incubated
group
within
BBB
model.
While
+
does
not
entirely
prevent
damage
induced
barrier,
exhibit
mitigating
on
damage.
In
HUVEC
cells,
significant
decrease
IL-8
levels
sesamol
groups.
T98G
were
elevated
group,
while
reduction
TNF-α
went
up
but
down
groups
cells.
Furthermore,
IL-6
increased
both
noted
cells
treatment.
The
increase
due
indicates
inflammatory
response.
It
contribute
enhanced
permeability.
result,
reduced
caused
controlling
IL-8,
IL-6,
TNF-α.
molecule
may
serve
therapeutic
role
diminishing
protecting
Molecules,
Journal Year:
2023,
Volume and Issue:
28(22), P. 7588 - 7588
Published: Nov. 14, 2023
Neurological
ailments,
including
stroke,
Alzheimer's
disease
(AD),
epilepsy,
Parkinson's
(PD),
and
other
related
diseases,
have
affected
around
1
billion
people
globally
to
date.
PD
stands
second
among
the
common
neurodegenerative
diseases
caused
as
a
result
of
dopaminergic
neuron
loss
in
midbrain's
substantia
nigra
regions.
It
affects
cognitive
motor
activities,
resulting
tremors
during
rest,
slow
movement,
muscle
stiffness.
There
are
various
traditional
approaches
for
management
PD,
but
they
provide
only
symptomatic
relief.
Thus,
survey
finding
new
biomolecules
or
substances
exhibiting
therapeutic
potential
patients
with
is
main
focus
present-day
research.
Medicinal
plants,
herbal
formulations,
natural
bioactive
molecules
been
gaining
much
more
attention
recent
years
synthetic
orchestrate
number
undesired
effects.
Several
vitro,
vivo,
silico
studies
past
demonstrated
medicinal
plant-based
bioactives.
Among
bioactives,
polyphenols,
terpenes,
alkaloids
particular
interest
due
their
potent
anti-inflammatory,
antioxidant,
brain-health-promoting
properties.
Further,
there
no
concise,
elaborated
articles
comprising
updated
mechanism-of-action-based
reviews
published
literature
on
potent,
recently
investigated
(2019-2023)
plant
based-bioactive
molecules,
alkaloids,
method
PD.
Therefore,
we
designed
current
review
an
illustration
efficacious
role
bioactives
(polyphenols,
alkaloids)
that
can
become
therapeutics
against
greater
specificity,
target
approachability,
bioavailability,
safety
host.
This
information
be
further
utilized
future
develop
several
value-added
formulations
nutraceutical
products
achieve
desired
efficacy
Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
12(11), P. 9094 - 9107
Published: Sept. 23, 2024
Abstract
Microglia
serve
as
the
primary
defense
mechanism
in
brain.
Artificial
sweeteners
are
widely
used
dietary
supplements,
though
their
long‐term
effects
remain
uncertain.
In
this
study,
we
investigated
of
sucralose
on
microglia
during
prolonged
exposure
via
neuroinflammatory
and
ferroptosis
pathways.
Initially,
human
microglial
clone
3
(HMC3)
cells
were
exposed
to
(0–50
mM)
for
24,
48,
72
h
investigate
short‐term
effects.
Subsequently,
HMC3
treated
with
1
mM
7,
14,
21
days
examine
We
measured
levels
interleukin‐1β
(IL‐1β),
NOD‐like
receptor
protein
(NLRP3),
8‐hydroxydeoxyguanosine
(8‐OHdG),
Sirtuin‐1
(SIRT1),
glutathione
peroxidase‐4
(GPx4),
reduced
(GSH),
malondialdehyde
(MDA),
ferrous
iron
(Fe
2+
),
caspase
3/7.
Additionally,
analyzed
impact
cell
morphology,
migration,
expression
IL‐1β,
NLRP3,
SIRT1,
GPx4.
Sucralose
inhibited
viability
proliferation
a
concentration‐
time‐dependent
manner
induced
membrane
nuclear
abnormalities.
Moreover,
significantly
migration
rate.
Long‐term
treatment
decreased
Fe
,
GPx4,
GSH,
SIRT1
while
increasing
MDA,
8‐OHdG,
3/7
activity.
also
enhanced
activation
neuroinflammation
by
upregulating
IL‐1β
NLRP3
downregulating
thereby
inducing
suppressing
viability.
Consequently,
high
concentrations
or
may
induce
targeting
SIRT1/NLRP3/IL‐1β/GPx4
pathway
cells.
