Characterization of cuproptosis signature in clear cell renal cell carcinoma by single cell and spatial transcriptome analysis DOI Creative Commons

Xiaohong Zou,

Xiaoqing Liu, Huiting Wang

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 24, 2024

Abstract Cuproptosis is a novel type to regulate cell death with copper-dependent manner, and has been reported involve in the occurrence development of various malignant tumors. However, association between cuproptosis tumor microenvironment (TME) clear renal carcinoma (ccRCC) remained unclear. To address this question, we integrated single RNA sequencing (scRNA-seq) datasets ccRCC across different stages, systematically examined distinctive expression patterns cuproptosis-related genes (CRGs) within TME ccRCC, explored crucial signatures using spatial transcriptome (ST-seq) dataset. The activities reduced cancer tissues along development, recovered after therapy. We identified HILPDA + ccRCC1 subtype, characterized hypoxia, as susceptible cells associated better prognosis. main co-expression modules subtype highlighted role anion transport, response oxygen species PD-L1-PD-1 pathway. Furthermore, immunosuppressive might interact via HAVCR2-LGALS9, C3-C3AR1, HLA-A-CD8B HLA-C-CD8A axises shape landscape. In summary, anticipate that study will offer valuable insights potential strategies for therapy ccRCC. Graphical

Language: Английский

Ferroptosis mechanisms and its novel potential therapeutic targets for DLBCL DOI Open Access

Wenxia Bian,

Haoran Li, Yuhan Chen

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116386 - 116386

Published: March 16, 2024

Diffuse large B-cell lymphoma (DLBCL), a heterogeneous lymphoid malignancy, poses significant threat to human health. The standard therapeutic regimen for patients with DLBCL is rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), typical cure rate of 50–70%. However, some either relapse after complete remission (CR) or exhibit resistance R-CHOP treatment. Therefore, novel approaches are imperative managing high-risk refractory DLBCL. Ferroptosis driven by iron-dependent phospholipid peroxidation, process that relies on the transition metal iron, reactive oxygen species (ROS), phospholipids containing polyunsaturated fatty acids-containing (PUFA-PLs). Research indicates ferroptosis implicated in various carcinogenic anticancer pathways. Several hematological disorders heightened sensitivity cell death induced ferroptosis. cells, particular, demonstrate an increased demand iron upregulation expression acid synthase. Additionally, there exists correlation between ferroptosis-associated genes prognosis may be promising target therapy. In this review, we elucidate mechanisms, its role DLBCL, potential targets This review offers insights into application treatment strategies

Language: Английский

Citations

12
Focus on cuproptosis: Exploring new mechanisms and therapeutic application prospects of cuproptosis regulation DOI Open Access

Donglin Hao,

Wei Luo,

Yongmin Yan

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117182 - 117182

Published: July 24, 2024

Cuproptosis is a novel form of regulated cell death, which plays an important role in the physiological and pathological processes human body. Despite increasing research on cuproptosis-related genes (CRGs) their correlation with diseases, pathogenesis diseases remains unclear. Furthermore, there lack reviews emerging technologies for regulating cuproptosis disease treatment. This study delves into copper-induced death mechanism, distinguishing from mechanisms like oxidative stress, glutathione synthesis inhibition, ubiquitin-proteasome system inhibition. Several long-standing mysteries such as Wilson's Menkes may be attributed to occurrence cuproptosis. In addition, we also review detection indicators related cuproptosis, providing targets diagnosis summarize application value tumor therapy better elucidate impact copper thus promote prospects possible strategies substances, ion chelators, carriers, nanomaterials, therapy.

Language: Английский

Citations

5
Renal cancer: signaling pathways and advances in targeted therapies DOI Creative Commons
Aimin Jiang, Jinxin Li,

Ziwei He

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: Aug. 1, 2024

Abstract Renal cancer is a highlyheterogeneous malignancy characterized by rising global incidence and mortalityrates. The complex interplay dysregulation of multiple signaling pathways,including von Hippel–Lindau ( VHL )/hypoxia‐inducible factor HIF ), phosphoinositide 3‐kinase PI3K )/protein kinase B AKT )/mammalian target rapamycin mTOR Hippo–yes‐associated protein YAP Wnt/ß‐catenin, cyclic adenosine monophosphate cAMP hepatocyte growth HGF )/ c‐Met , contribute to theinitiation progression renal cancer. Although surgical resection thestandard treatment for localized cancer, recurrence metastasiscontinue pose significant challenges. Advanced associatedwith poor prognosis, current therapies, such as targeted agents andimmunotherapies, have limitations. This review presents comprehensiveoverview the molecular mechanisms underlying aberrant pathways inrenal emphasizing their intricate crosstalk synergisticinteractions. We discuss recent advancements in includingtyrosine inhibitors, immunotherapies, checkpoint inhibitors.Moreover, we underscore importance multiomics approaches networkanalysis elucidating regulatory networks governing cancerpathogenesis. By integrating cutting‐edge research clinical insights, this contributesto development innovative diagnostic therapeutic strategies, whichhave potential improve risk stratification, precision medicine, andultimately, patient outcomes

Language: Английский

Citations

5
Recent advances in the medical applications of two-dimensional MXene nanosheets DOI
Gokul Paramasivam,

Yadavali Siva Prasad,

Raji Atchudan

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 22

Published: Nov. 18, 2024

MXene-based materials are gaining significant attention due to their exceptional properties and adaptability, leading diverse advanced applications. In 3D printing, MXenes enhance the performance of photoblockers, photocurable inks, composites, enabling creation precise, flexible durable structures. MXene/siloxane composites offer both flexibility resilience, while MXene/spidroin scaffolds provide excellent biocompatibility mechanical strength, making them ideal for tissue engineering. Sustainable inks such as MXene/cellulose nano alginate/MXene MXene/emulsion underscore role in high-performance printed materials. cancer therapy, enable innovative photothermal photodynamic therapies, where nanosheets generate heat reactive oxygen species destroy cells. MXene theranostic nanoprobes combine imaging treatment, MXene/niobium support hyperthermia therapy hydrogels allow controlled drug release. Additionally, nanozymes catalytic activity, MXene/gold nanorods near-infrared-triggered release noninvasive treatments. antimicrobial applications, material durability hygiene, providing anticorrosive protection metals. For instance, MXene/graphene, MXene/polycaprolactone nanofibers MXene/chitosan exhibit antibacterial activity. sensors have been developed detect antibiotic residues. cryogels also promote regeneration, nanohybrids facilitate photocatalytic therapy. These advancements potential regenerative medicine other fields.

Language: Английский

Citations

4
Low expression of CDHR4 predicts a favorable prognosis in patients with KIRC DOI Creative Commons
Jinbo Yuan, Huijuan Luo, Hui Liu

et al.

Asian Journal of Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Cuproptosis-related genes and agents: implications in tumor drug resistance and future perspectives DOI Creative Commons

Lingwen Xu,

Xiaolan Cao,

Yuxiao Deng

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

In the field of tumor treatment, drug resistance remains a significant challenge requiring urgent intervention. Recent developments in cell death research have highlighted cuproptosis, mechanism induced by copper, as promising avenue for understanding biology and addressing resistance. Cuproptosis is initiated dysregulation copper homeostasis, which turn triggers mitochondrial metabolic disruptions induces proteotoxic stress. This process specifically entails accumulation lipoylated proteins depletion iron-sulfur cluster within context tricarboxylic acid cycle. Simultaneously, it accompanied activation distinct signaling pathways that collectively lead to death. Emerging evidence highlights critical role cuproptosis However, core molecular mechanisms regulation microenvironment, clinical translation still require further exploration. review examines intersection resistance, detailing essential roles cuproptosis-related genes exploring therapeutic potential ionophores, chelators, nanodelivery systems. These offer promise overcoming advancing precision medicine. By elucidating underlying this study aims identify novel strategies targets, thereby paving way development innovative anti-cancer drugs.

Language: Английский

Citations

0
Characterization of cuproptosis signature in clear cell renal cell carcinoma by single cell and spatial transcriptome analysis DOI Creative Commons

Xiaohong Zou,

Xiaoqing Liu, Huiting Wang

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 24, 2024

Abstract Cuproptosis is a novel type to regulate cell death with copper-dependent manner, and has been reported involve in the occurrence development of various malignant tumors. However, association between cuproptosis tumor microenvironment (TME) clear renal carcinoma (ccRCC) remained unclear. To address this question, we integrated single RNA sequencing (scRNA-seq) datasets ccRCC across different stages, systematically examined distinctive expression patterns cuproptosis-related genes (CRGs) within TME ccRCC, explored crucial signatures using spatial transcriptome (ST-seq) dataset. The activities reduced cancer tissues along development, recovered after therapy. We identified HILPDA + ccRCC1 subtype, characterized hypoxia, as susceptible cells associated better prognosis. main co-expression modules subtype highlighted role anion transport, response oxygen species PD-L1-PD-1 pathway. Furthermore, immunosuppressive might interact via HAVCR2-LGALS9, C3-C3AR1, HLA-A-CD8B HLA-C-CD8A axises shape landscape. In summary, anticipate that study will offer valuable insights potential strategies for therapy ccRCC. Graphical

Language: Английский

Citations

0