Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 761, P. 110188 - 110188
Published: Oct. 25, 2024
Language: Английский
Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(3)
Published: March 1, 2025
Language: Английский
Citations
1
Biology Direct, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 15, 2025
Thioredoxin1 (TRX1) and telomerase are both attractive oncology targets that tightly implicated in tumor initiation development. Here, we reported the 6-dithio-2-deoxyguanosine analog thiotert exhibits an effective cytotoxic effect on myelodysplastic syndromes (MDS) cell SKM-1 lymphoma U-937. Further studies confirmed effectively disrupts cellular redox homeostasis, as evidenced by elevated intracellular reactive oxygen species (ROS) levels, increased MnSOD, accelerated DNA impairment, activated apoptosis signal. Mechanistically, our present study revealed treatment inhibited function of TRX1/TRXR1 system reverse transcriptase (TERT), rendering oxidative damage impairment telomeres. Meanwhile, pharmacological administration glutathione (GSH), N-acetylcysteine (NAC), mitoquinone (MitoQ), or genetic overexpression TRX1 TERT MDS cells could dampen toxicity caused thiotert. Remarkably, vivo mouse model demonstrated exhibited greater efficacy reduction compared to conventional chemotherapy drug cytarabine. Collectively, these results provide experimental insights into mechanism thiotert-induced death unveil may be promising new for future treatment.
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 23, 2025
Thyroid cancer (TC) represents the most prevalent malignancy within endocrine system. In recent years, there has been a marked global increase in incidence of thyroid cancer, garnering substantial scientific interest. Comprehensive investigations into pathogenesis TC have identified significant association with ferroptosis, newly characterized form cell death mediated by iron ions. Distinct from apoptosis, necrosis, and autophagy, ferroptosis is accumulation lipid peroxides reactive oxygen species, culminating cellular damage death.Recent research elucidated connection between initiation, progression, treatment cancer. These findings underscore significance offer valuable insights development novel therapeutic strategies precise predictive markers. The unique mechanisms present opportunities for targeting treatment-resistant cancers. Consequently, regulation may emerge as target, potentially addressing limitations current treatments. Moreover, elucidating molecular underpinning facilitate identification biomarkers early detection prognostication. This review endeavors to synthesize extant knowledge regarding role examine potential implications, propose future trajectories enhance understanding clinical application ferroptosis.
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: April 16, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 9, 2024
Lung cancer has high metastasis and drug resistance. The prognosis of lung patients is poor the patients’ survival chances are easily neglected. Ferroptosis a programmed cell death proposed in 2012, which differs from apoptosis, necrosis autophagy. novel type regulated driven by iron-dependent lipid peroxidation subsequent plasma membrane ruptures. It broad prospects field tumor disease treatment. At present, multiple studies have shown that biological compounds can induce ferroptosis cells, exhibits significant anti-cancer effects, they advantages safety, minimal side less possibility to In this review, we summarize used for treatment focusing on its mechanism. addition, systematically review current research status combining nanotechnology with treatment, shed new light targeting pathways applying compounds-based therapies.
Language: Английский
Citations
3
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137117 - 137117
Published: Nov. 1, 2024
Language: Английский
Citations
2
Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)
Published: July 3, 2024
Despite being characterized by high malignancy, morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC) has not been fully elucidated. Ferroptosis, a non-apoptotic form regulated cell death, possesses distinct morphological, biochemical, genetic characteristics compared to other types death. Dysregulated actions within molecular network that regulates ferroptosis have identified as significant contributors progression HCC. Long non-coding RNAs (lncRNAs) emerged influential diverse cellular processes, regulating gene function expression through multiple mechanistic pathways. An increasing body evidence indicates deregulated lncRNAs are implicated in malignant events such proliferation, growth, invasion, metabolism influencing Therefore, elucidating inherent role modulatory functions on HCC might promote development novel therapeutic interventions for this disease. This review provides succinct overview roles ferroptosis-related treatment, aiming drive promising targets biomarkers patients.
Language: Английский
Citations
1
Published: July 30, 2024
Traditional medicines and their active ingredients some natural products derived analogs have been used for treating multiple diseases including cancer. Among these compounds cytotoxic agents such as bleomycin, paclitaxel vincristine block essential pathways genes required cancer cell growth diverse clinical applications. Dietary phenolics flavonoids related are associated with health benefits however most individual dietary other that show promising anticancer activity in preclinical studies exhibit minimal effectiveness this is particularly true Many of the perform poorly trials due to pharmacokinetic consideration limited uptake (e.g., curcumin) issues can be addressed. The many product-derived also enhanced by a more targeted approach. This would include identifying significant response/gene or target specific then optimal compound. In review, I discussed number targets non-oncogene addiction Sp transcription factors, reactive oxygen species (ROS) orphan nuclear receptor 4A (NR4A) sub-family. Thus, compound responses could only patients ROS-inducible highly express Sp1 NR4A sub-family members. A mechanism-based precision medicine approach should enhance efficacy decrease toxic side effects combination therapies.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11384 - 11384
Published: Oct. 23, 2024
Diffuse large B-cell lymphoma (DLBCL) is a malignancy of immense biological and clinical heterogeneity. Based on the transcriptomic or genomic approach, several different classification schemes have evolved over years to subdivide DLBCL into clinically (prognostically) relevant subsets, but each leaves unclassified samples. Herein, we outline tumor biology behind actual potential drug targets address challenges drawbacks coupled with their (potential) use. Therapeutic modalities are discussed, including small-molecule inhibitors, naked antibodies, antibody-drug conjugates, chimeric antigen receptors, bispecific antibodies T-cell engagers, immune checkpoint inhibitors. Candidate drugs explored in ongoing trials diverse toxicity issues refractoriness drugs. According literature DLBCL, promise for new therapeutic lies epigenetic alterations, receptor NF-κB pathways. present putative hiding lipid pathways, ferroptosis, gut microbiome that could be used addition immuno-chemotherapy improve general health status patients, thus increasing chance being cured. It may time devote more effort exploring metabolism discover novel druggable targets. We also performed bibliometric knowledge-map analysis published from 2014-2023.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11250 - 11250
Published: Oct. 19, 2024
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma, and it highly aggressive heterogeneous. Targeted therapy still main treatment method used in clinic due to its lower risk of side effects personalized medication. Excessive activation PI3Kδ DLBCL leads abnormal PI3K/Akt pathway, promoting occurrence development DLBCL. The existing inhibitors limit their clinical application. discovery with novel structures minimal urgently needed. This study constructed a inhibitor screening model screen natural product libraries. Revealing mechanism for through network pharmacology, kinase assays, molecular dynamics. results docking indicated that Silibinin had high score good binding mode PI3Kδ. pharmacology could exert therapeutic on by inhibiting activity affecting pathway. assays concentration dependently inhibited dynamics stably bind was structurally 3,5,7-trihydroxychroman-4-one inhibitor, providing valuable information subsequent inhibitors.
Language: Английский
Citations
0