Cell Reports,
Journal Year:
2025,
Volume and Issue:
44(3), P. 115400 - 115400
Published: March 1, 2025
Highlights•Piezo1
inhibition
promotes
colon
stem
cell
proliferation•SCD1
is
downstream
of
Piezo1
to
affect
stemness•Impaired
stemness
associated
with
fatty
acid
metabolism
in
crypts•GsMTX4
has
a
protective
effect
on
injured
colitis
colonoidsSummaryPiezo1,
which
maintains
the
integrity
and
function
intestinal
epithelial
barrier,
essential
for
colonic
homeostasis.
However,
whether
how
regulates
fate
remains
unclear.
Here,
we
show
that
proliferation.
Mechanistically,
stearoyl-CoA
9-desaturase
1
(SCD1)
by
acting
Wnt-β-catenin
pathway.
For
mice,
altered
after
knockdown
activation
was
accompanied
reprogrammed
(FA)
crypts.
Notably,
found
GsMTX4
protects
mouse
human
organoids.
Our
results
elucidated
role
regulating
normal
postinjury
fates
through
SCD1-Wnt-β-catenin
SCD1-mediated
FA
desaturation
process.
These
provide
fresh
perspectives
mechanical
factors
therapeutic
strategies
related
diseases.Graphical
abstract
Seminars in Cancer Biology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
Elevated
lipid
metabolism
is
one
of
hallmarks
malignant
tumors.
Lipids
not
only
serve
as
essential
structural
components
biological
membranes
but
also
provide
energy
and
substrates
for
the
proliferation
cancer
cells
tumor
growth.
Cancer
meet
their
needs
by
coordinating
processes
absorption,
synthesis,
transport,
storage,
catabolism.
As
research
in
this
area
continues
to
deepen,
numerous
new
discoveries
have
emerged,
making
it
crucial
scientists
stay
informed
about
developments
metabolism.
In
review,
we
first
discuss
relevant
concepts
theories
or
assumptions
that
help
us
understand
-based
therapies.
We
then
systematically
summarize
latest
advancements
including
mechanisms,
novel
targets,
up-to-date
pre-clinical
clinical
investigations
anti-cancer
treatment
with
targeted
drugs.
Finally,
emphasize
emerging
directions
therapeutic
strategies,
future
prospective
challenges.
This
review
aims
insights
guidance
field
Cancer Cell International,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Aug. 22, 2024
Cancer
is
closely
related
to
lipid
metabolism,
with
the
tumor
microenvironment
(TME)
containing
numerous
metabolic
interactions.
cells
can
bidirectionally
interact
immune
and
stromal
cells,
major
components
of
TME.
This
interaction
primarily
mediated
by
fatty
acids
(FAs),
cholesterol,
phospholipids.
These
interactions
lead
various
physiological
changes,
including
suppression,
cancer
cell
proliferation,
dissemination,
anti-apoptotic
effects
on
cells.
The
modulation
resulting
from
this
metabolism-associated
crosstalk
between
immune/stromal
provides
valuable
insights
into
prognosis.
A
comprehensive
literature
review
was
conducted
examine
function
bidirectional
metabolism
within
TME,
particularly
how
these
influence
novel
autophagy-extracellular
vesicle
(EV)
pathway
has
been
proposed
as
a
mediator
cells/stromal
impacting
As
result,
different
forms
have
described
being
linked
prognosis,
those
autophagy-EV
pathway.
In
conclusion,
understanding
stromal/immune
in
TME
help
develop
more
advanced
prognostic
approaches
for
patients.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Sept. 10, 2024
Endometrial
cancer
is
one
of
the
major
gynecological
cancers,
with
increasing
incidence
and
mortality
in
past
decades.
Emerging
preclinical
clinical
data
have
indicated
its
close
association
obesity
dyslipidemia.
Metabolism
reprogramming
has
been
considered
as
hallmark
cancer,
to
satisfy
extensive
need
nutrients
energy
for
survival
growth.
Particularly,
lipid
metabolism
aroused
researchers'
interest
field
including
tumorigenesis,
invasiveness,
metastasis,
therapeutic
resistance
immunity
modulation,
etc.
But
roles
endometrial
not
fully
understood.
This
review
summarized
how
induces
oncogenesis
progression
biological
functions
aberrant
pathway
altered
transcription
regulation
pathway.
Besides,
we
proposed
novel
strategies
targeting
concentrated
on
potential
sensitizing
immunotherapy
hormonal
therapy,
further
optimize
existing
treatment
modalities
patients
advanced/metastatic
cancer.
Moreover,
expect
that
plus
hormone
therapy
may
block
malignant
transformation
enrich
preventative
approaches
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(2), P. 81 - 81
Published: Jan. 27, 2025
In
this
work,
we
studied
the
relationships
between
most
representative
fatty
acids
(FAs)
and
their
ratios
in
red
blood
cell
(RBC)
membranes
dietary
alongside
several
cardiometabolic
risk
factors.
Twenty-six
individuals
were
enrolled
with
a
mean
age
of
50.4
±
12.7
years
(16
males
10
females).
By
bivariate
analysis,
oleic
acid
(OA)
correlated
negatively
C20:4n-6
(AA)
(p
=
0.031)
RBCs.
With
multivariate
regression
OA
<
0.001)
is
an
independent
predictor
associated
AA
levels
RBCs,
while
elongation
very-long-chain
6
(ELOVL6)
stearoyl-CoA
desaturase
16
(SCD16)
activities
0.05)
was
positively
The
models
also
showed
that
C22:5n-3
(DPA)
Furthermore,
BMI
SCD16,
both
SCD16
SCD18
triacylglycerols
levels.
addition,
significantly
LDL-c
LDL-c/HDL-c
ratio
ApoA1/ApoB
ratio,
ELOVL6
HDL
molecular
subfractions.
Therefore,
our
data
underline
OA,
can
interfere
n-3
n-6
partition
biomembranes
such
as
suggesting
important
(patho)physiological
regulatory
mechanism
role
controlling
bioactive
molecules’
availability
those
involved
immune-inflammatory
response.
Journal of Cellular Physiology,
Journal Year:
2025,
Volume and Issue:
240(2)
Published: Feb. 1, 2025
ABSTRACT
The
dysregulation
of
perivascular
adipose
tissue
(PVAT)
is
a
key
contributor
to
obesity‐induced
vascular
dysfunction.
Mouse
periaortic
divided
into
two
parts:
thoracic
(TPVAT)
and
abdominal
(APVAT).
These
parts
have
different
physiological
properties,
which
translate
effects
on
the
wall
in
onset
metabolic
syndrome.
Stearoyl‐CoA
desaturase
1
(SCD1)
an
enzyme
that
involved
synthesis
monounsaturated
fatty
acids
has
been
shown
play
important
role
syndrome,
including
homeostasis.
Despite
considerable
focus
SCD1
development
disorders,
there
currently
lack
knowledge
relationship
between
PVAT.
present
study
investigated
deficiency
lipolysis,
β‐oxidation,
mitochondrial
dynamics,
inflammation
mouse
TPVAT
APVAT
under
high‐fat
diet
(HFD)
feeding
conditions.
We
found
lower
triglyceride
levels
PVAT
−/−
mice
both
vitro
vivo
compared
with
wildtype
adipocytes,
attributable
activated
lipolysis
β‐oxidation.
Moreover,
HFD‐fed
was
characterized
by
higher
oxidative
phosphorylation
complexes
respiratory
potential
alterations
morphology
mice.
Furthermore,
showed
signs
greater
pro‐inflammatory
macrophage
polarization
inflammatory
markers
were
induced
HFD.
This
may
be
related
accumulation
free
diacylglycerols,
are
enriched
saturated
acids.
findings
elucidate
maintaining
integrity.
Foods,
Journal Year:
2025,
Volume and Issue:
14(5), P. 770 - 770
Published: Feb. 24, 2025
Hyperlipidemia
is
characterized
by
a
high
level
of
blood
lipid
which
poses
serious
threat
to
human
health.
Coix
seed
traditional
crop
medicine
and
food
homology
with
wide
range
pharmacological
actions.
To
make
clear
the
attenuation
effect
coix
against
hyperlipidemia,
low
doses
extract
(CSE)
were
orally
administered
hyperlipidemia
model
mice
developed
high-fat
diet
(HFD).
Our
results
showed
that
CSE
notably
improved
liver
pathological
injury,
oxidative
stress,
declined
levels
glucose
in
mice.
Liver
metabolomics
lipid-related
metabolites
decreased,
pathways
glycolipid
metabolism
seriously
affected
intervention.
Moreover,
16S
rRNA
sequencing
revealed
treatment
increased
diversity
gut
microbiota.
Meanwhile,
microbiota
function
regulating
intestinal
balance
as
well
relieving
obesity
nervous
diseases
significantly
enhanced
while
harmful
flora
decreased
after
The
network
pharmacology
molecular
docking
indicated
PPAR
signaling
pathway
may
be
core
path
anti-hyperlipidemia
for
seeds.
RT-qPCR
further
verified
expression
genes
from
changed
fat
synthesis
lipolysis
enhanced.
Therefore,
might
potential
candidate
hyperlipidemia.
