The role of miRNAs in the extracellular vesicle-mediated interplay between breast tumor cells and cancer-associated fibroblasts DOI Open Access
Chen Li, Chao Yang, Qifeng Yang

et al.

Journal of Cancer Metastasis and Treatment, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

The tumor microenvironment (TME) of breast cancer (BC) is depicted as an immunosuppressive dwelling that comprises a myriad cell types embedded in the extracellular matrix. As one most abundant populations within TME, cancer-associated fibroblasts (CAFs) play indispensable roles increasing aggressiveness and promoting resistance to standard-of-care therapies. Extracellular vesicles (EVs) represent diverse array biological nanoparticles, encompassing exosomes, microvesicles, apoptotic bodies. In recent years, these cell-derived membranous structures have raised great interest they can encapsulate numerous cellular cargo, such proteins, lipids, miRNAs. By transmitting bioactive content recipient cells, EVs pivotal intercellular communication between CAFs cells. secreted from cells typically activate resident acquire myofibroblastic phenotype, while diffused by CAFs, turn, substantially increase progression BC. This review summarizes latest findings highlight functional role EV especially miRNAs, regulatory network. A better understanding EV-mediated cell-cell interactions crucial achieving effective treatment patients with

Language: Английский

Unveiling the Link Between Chronic Inflammation and Cancer DOI Creative Commons

Siddhant Tripathi,

Yashika Sharma, Dileep Kumar

et al.

Metabolism Open, Journal Year: 2025, Volume and Issue: 25, P. 100347 - 100347

Published: Jan. 9, 2025

The highly nuanced transition from an inflammatory process to tumorigenesis is of great scientific interest. While it well known that environmental stimuli can cause inflammation, less about the oncogenic modifications chronic inflammation in tissue microenvironment bring about, as how these set off pro-tumorigenic processes. It clear no matter where factors come from, maintaining encourages carcinogenesis. In addition encouraging angiogenesis and metastatic processes, sustaining survival proliferation malignant transformed cells, possibly altering efficacy therapeutic agents, negatively regulate antitumoral adaptive innate immune responses. Because has multiple pathways involved metastasis, gained recognition a marker cancer desirable target for therapy. Recent advances our knowledge molecular mechanisms drive cancer's progression demonstrate promotes metastasis while suppressing anti-tumor immunity. many solid tumor types, including breast, lung, liver cancer, stimulates activation oncogenes impairs body's defenses against tumor. Additionally, alters As tactical approach treatment, findings have underscored importance targeting pathways. This review highlights role development focusing on its impact progression, suppression, therapy resistance. examines current anti-inflammatory strategies, NSAIDs, cytokine modulators, STAT3 inhibitors, addressing their potential limitations. emphasizes need further research unravel complex linking identify targets specific subtypes.

Language: Английский

Citations

2
Theoretical Framework and Emerging Challenges of Lipid Metabolism in Cancer DOI Creative Commons
Qiuying Gu, Yuan Wang, Ping Yi

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Elevated lipid metabolism is one of hallmarks malignant tumors. Lipids not only serve as essential structural components biological membranes but also provide energy and substrates for the proliferation cancer cells tumor growth. Cancer meet their needs by coordinating processes absorption, synthesis, transport, storage, catabolism. As research in this area continues to deepen, numerous new discoveries have emerged, making it crucial scientists stay informed about developments metabolism. In review, we first discuss relevant concepts theories or assumptions that help us understand -based therapies. We then systematically summarize latest advancements including mechanisms, novel targets, up-to-date pre-clinical clinical investigations anti-cancer treatment with targeted drugs. Finally, emphasize emerging directions therapeutic strategies, future prospective challenges. This review aims insights guidance field

Language: Английский

Citations

5
Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential DOI Creative Commons

Shiming Tan,

Wenjuan Yang, Zongyao Ren

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 19, 2025

In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing particularly promising avenue investigation. The identification ncRNA-encoded in human cancers is increasing. These regulate cancer progression through multiple molecular mechanisms. Here, we delineate patterns diverse and provide synopsis methodologies employed for that possess capacity to encode these peptides. Furthermore, discuss impacts on biological behavior cells underlying conclusion, describe prospects challenges need be overcome.

Language: Английский

Citations

0
The role of miRNAs in the extracellular vesicle-mediated interplay between breast tumor cells and cancer-associated fibroblasts DOI Open Access
Chen Li, Chao Yang, Qifeng Yang

et al.

Journal of Cancer Metastasis and Treatment, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

The tumor microenvironment (TME) of breast cancer (BC) is depicted as an immunosuppressive dwelling that comprises a myriad cell types embedded in the extracellular matrix. As one most abundant populations within TME, cancer-associated fibroblasts (CAFs) play indispensable roles increasing aggressiveness and promoting resistance to standard-of-care therapies. Extracellular vesicles (EVs) represent diverse array biological nanoparticles, encompassing exosomes, microvesicles, apoptotic bodies. In recent years, these cell-derived membranous structures have raised great interest they can encapsulate numerous cellular cargo, such proteins, lipids, miRNAs. By transmitting bioactive content recipient cells, EVs pivotal intercellular communication between CAFs cells. secreted from cells typically activate resident acquire myofibroblastic phenotype, while diffused by CAFs, turn, substantially increase progression BC. This review summarizes latest findings highlight functional role EV especially miRNAs, regulatory network. A better understanding EV-mediated cell-cell interactions crucial achieving effective treatment patients with

Language: Английский

Citations

0