Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 185, P. 117936 - 117936
Published: March 8, 2025
Language: Английский
eNeurobiología, Journal Year: 2025, Volume and Issue: 16(40)
Published: Jan. 16, 2025
La nanomedicina es el nombre que se asigna a las tecnologías nanométricas aplicadas al cuidado de la salud, cuales han permitido desarrollo estrategias innovadoras para tratamiento y diagnóstico diversas enfermedades, incluidas aquellas afectan sistema nervioso central. En particular, debido ventajas conferidas por sus características intrínsecas, nanomedicinas explorado como una posible alternativa terapéutica permita optimizar control crisis epilépticas epilepsia través diversos enfoques, pueden incluir mejorar farmacocinética los fármacos anticrisis, reducir efectos adversos, aumentar su eficacia y, en algunos casos, superar farmacorresistencia. Estas posicionan herramienta muy atractiva ayude desafíos imposibilitado óptimo ciertos casos particulares, Esta revisión aborda aspectos generales sobre epilepsia, proporcionando un contexto fisiopatología asociados con tratamientos esta enfermedad. Además, recopilan evidencias evaluado uso potencial diferentes modelos animales agudas, así responsiva refractaria tratamiento, desde enfoque ciencia básica. Estos estudios proporcionan evidencia fundamental, ámbito medicina traslacional, sienta bases futuras aplicaciones trasladarse eventualmente práctica clínica trastornos epilépticos.
Citations
1
Virology, Journal Year: 2025, Volume and Issue: 604, P. 110399 - 110399
Published: Jan. 18, 2025
Infectious bronchitis virus (IBV), an avian coronavirus, member of the genus Gammacoronavirus, poses significant threats to poultry health, causing severe respiratory, reproductive, and renal infections. The genetic diversity IBV, driven by mutations, recombination deletions, has led emergence numerous serotypes genotypes, complicating both diagnosis control measures. Rapid accurate diagnostic tools are essential for effective disease management minimizing economic losses. Conventional methods, such as PCR, isolation, serological assays, hindered limitations in sensitivity, specificity, turnaround time. In contrast, innovative biosensor platforms employing advanced detection mechanisms-including electrochemical, optical, piezoelectric sensors-offer a transformative solution. These technologies provide portable, highly sensitive, rapid IBV detection. Beyond addressing challenges conventional these biosensor-based approaches facilitate real-time monitoring enhance surveillance. This review highlights potential biosensors their integration into strategies coronavirus infections, presenting them promising alternative precise efficient
Language: Английский
Citations
1
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8948 - 8948
Published: Oct. 4, 2024
Using nanostructured drug delivery systems has attracted increasing interest in immunotherapeutic approaches. The intrinsic immunomodulatory properties and versatility of nanoparticles used as carriers were consistently reported to augment treatment efficiency nanoscaled materials increase accumulation at the desired site, enhance cell internalization, improve therapeutic outcomes. Thus, numerous studies have exploited potential use vehicles delivering different cargo a promising alternative for treating conditions like cancer, autoimmune diseases, infectious allergic immune disorders. In this context, paper presents solid basis innovations, highlighting their advantages improving strategies, reviewing clinical applications, discussing existing challenges ways overcome them.
Language: Английский
Citations
7
International Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 6, 2024
Introduction Considered one of the most significant medical discoveries 20th century, antibiotics have transformed healthcare by preventing countless deaths caused bacterial infections. However, antibiotic resistance is a powerful foe that has emerged because overuse and misuse. Antimicrobial poses an immediate threat to public health around world, accounting for at least 1.27 million globally about 5 fatalities in 20191. The efficacy seriously threatened current global crisis, endangering our capacity treat common diseases. Antibiotic main risks modern development, food security, health, it increasing concern2. Anyone, anywhere any age, can become resistant antibiotics2. Worldwide, prevalence dangerously high levels2. Every year, 2.8 antibiotic-resistant diseases happen United States1. CDC (Centers Disease Control Prevention) estimates that, as result, more than 35 000 people pass away1. More $4.6 billion spent on treatment infections each year States due six multidrug-resistant bacteria are commonly identified settings1. Our infectious under from new mechanisms emerging spreading globally2,3. Given urgency problem, thorough grasp epidemiology, local dynamics, influencing emergence necessary. Antibiotics used array diseases, including gonorrhea, pneumonia, TB (tuberculosis), salmonellosis, losing their effectiveness2. Dedicated prevention infection control initiatives decreased mortality antimicrobial-resistant 18% nationwide nearly 30% hospitals, according CDC's 2019 AR Threats Report1. 2022 special report impact COVID-19 States, portion advancement was lost epidemic1. In 2020, pandemic drove towns, departments, facilities brink collapse, making extremely difficult continue progress being made fight against resistance1. Although developed country, much challenging problems low- middle-income nations. these resource-poor environments, frontline personnel face particular challenges quest deliver high-quality while negotiating murky waters resistance. This article analyzes tactics enable professionals tackle effectively preserve effectiveness future generations. It also digs into nuances difficulties. Urgent complexities managing Low- countries (LMICs) affected high-income widespread misuse, use agriculture, poor drug quality, inadequate surveillance, other factors related standards, malnutrition, chronic recurrent infections, inability afford expensive effective drugs4. Due systems knowledge, all becoming LMISs daily basis. environments with limited resources, providers crucial system LMICs must deal problem stability adequacy necessary treatments imperiled worldwide epidemic far-reaching effects, presents tough challenge already demanding situation. issue increasingly pressing, encounter difficulties this resources. These include lack finances, infrastructure, restricted access diagnostic equipment, knowledge training5. When deciding whether needed, accurate diagnosis essential, but LMICs, usually required equipment skilled staff. While balancing requirements varied populations universal unique challenges. frequency empirical which influenced things like patient load shortage staff, tools, pharmaceuticals, important topic needs research. Relying too may unintended consequence breeding microorganisms drugs. conservative approach brought forth deficiency, often provided first resort, exacerbates To combat resistance, strike careful balance between meeting patients' needs, prescribing administering accordance best practices, giving proper care. addition maintaining delicate balance, workers frequently struggle application ignorance World Health Organization's AWaRe framework6. be worse improper prescription distribution, result understanding execution Patients who colonized organisms (MDROs) markedly increased risk infection, regardless occur institutions or community. higher then insufficient even therapy failure, raise death rates end. Furthermore, worse, severely constrained larger socioeconomic issues areas resources7. livelihoods general well-being impacted communities adversely problems, knock-on effect. lessen severe effects susceptible essential address interconnected entirety. emergencies light fragility LMICs8. crises, they past, present, perhaps occurrences, could put additional demand professionals' abilities, confront severe. combination ongoing concerns creates complex challenge. Healthcare several opposing such continuing appropriately ensuring concurrent management. Strategies combating necessitates comprehensive multidimensional strategy. First foremost, there should focus expanding encouraging good hygiene habits stave off strengthened, includes infrastructural investments, hiring qualified guaranteeing medications available. solve cooperation governmental bodies, non-governmental groups, international organizations crucial. Governments relevant make investments fortify enhancing facilities, personnel, supply medications. Campaigns awareness educating negative use. ChatGPT helpful tackling patients, providers, easily accessible customized information. applicability, dependability, influence field travel medicine were documented Choudhary Priyanka9 article. comes advice prescriptions antibiotics, dosing schedules, significance finishing courses, dependable resource. sales regulated, drugs only way obtain them order prevent over-the-counter availability. Moreover, Priyanka et al. reported nano vaccines proven ability boost theimmune halt spread diseases10. With vaccines, growing Mycobacterium tuberculosis, causes controlled11. As research sector advances, potential transform worrying development attenuated inactivated viruses previously create vaccinations, revolutionary method developing recently been found relies molecule known messenger RNA (mRNA) rather live viruses10. mRNA vaccinations activate body's immune mount focused defense contrast lead targeting bacteria. need hour modify efficient mRNA-based vaccine candidates major scientific community keeping eye vaccines' stability, delivery, associated adverse effects10. Encouraging novel diagnostics, guarantee potent instruments fighting collaboration halting cross-border germs antibiotics. Combining approaches will reduce ensure life-saving remain M. controlled. Ethics approval type doesn't ethical approval. Patient consent No patients included. Sources funding authors not received funds. Author contribution All equally contributed manuscript approved publication final manuscript. Conflicts interest disclosure declare no financial conflicts regard content report. Research registration identifying number (UIN) None. Clinical trial clinical trial. Guarantor Tooba Ali. Provenance peer review Not commissioned, externally peer-reviewed. Data availability statement
Language: Английский
Citations
6
Biochemical and Biophysical Research Communications, Journal Year: 2023, Volume and Issue: 688, P. 149126 - 149126
Published: Nov. 3, 2023
Language: Английский
Citations
15
International Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 19, 2024
Background: Although the coronavirus disease 2019 (COVID-19) pandemic has exerted potential impact on patients with glioblastomas (GBMs), it remains unclear whether survival and its related risk factors of GBM would be altered or not during period spanning from pre- to post- COVID-19 era. This study aimed clarify important issues above. Methods: Two observational cohorts were utilized, including nationwide American cohort Surveillance, Epidemiology, End-Results (SEER) Chinese glioblastoma (CGC) at our institution 2018-2020. Demographics, tumor features, treatment regimens clinical outcomes collected. Cox regression model, competing subgroup sensitivity analysis used dynamically estimate relevant over different diagnosis years (2018 2019) post-COVID-19 (2020) pandemic. Causal mediation was further adopted explore relationship between mortality. Results: included 11321 cases in SEER 226 CGC, respectively. Instead diagnostic 2018-2020, prognostic factors, such as advanced age, bilateral absence comprehensive therapy (surgery combined chemoradiotherapy), identified persistently affect independently 2018 2020 (all P < 0.05). In lack for restated same timeframe. showed that effect all-cause mortality played a determinant role (direct value -0.227, 95% confidence interval -0.248 -0.207), which partially mediated by age (9.11%) rather than laterality. Conclusions: As timeframe shifted pandemic, remained stable, yet tumors, passive continuingly impacted survival. It is necessary optimize even post-pandemic
Language: Английский
Citations
5
Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(2), P. 696 - 710
Published: Jan. 6, 2025
Language: Английский
Citations
0
International Journal of Surgery, Journal Year: 2025, Volume and Issue: 111(3), P. 2590 - 2602
Published: Jan. 7, 2025
The immune response is modulated by a diverse array of signals within the tissue microenvironment, encompassing biochemical factors, mechanical forces, and pressures from adjacent tissues. Furthermore, extracellular matrix its constituents significantly influence function cells. In case carcinogenesis, changes in biophysical properties tissues can impact received cells, these c1an be translated into through mechano-transduction pathways. These pathways have profound on cellular functions, influencing processes such as cell activation, metabolism, proliferation, migration, etc. Tissue mechanics may undergo temporal during process offering potential for novel dynamic levels regulation. Here, we review advances mechanoimmunology malignancy studies, focusing how mechanosignals modulate behaviors cells at level, thereby triggering an that ultimately influences development progression malignant tumors. Additionally, also focused mechano-immunoengineering systems, with help which could to further understand tumor or alterations microenvironment provide new research directions overcoming immunotherapeutic resistance
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 126 - 126
Published: Jan. 27, 2025
Infectious diseases continue to pose a significant global health threat. To combat these challenges, innovative vaccine technologies are urgently needed. Nanoparticles (NPs) have unique properties and emerged as promising platform for developing next-generation vaccines. revolutionizing the field of development, offering new era immunization. They allow creation more effective, stable, easily deliverable Various types NPs, including lipid, polymeric, metal, virus-like particles, can be employed encapsulate deliver components, such mRNA or protein antigens. These NPs protect antigens from degradation, target them specific immune cells, enhance antigen presentation, leading robust durable responses. Additionally, simultaneously multiple antigens, adjuvants, in single formulation, simplifying production administration. Nanovaccines offer approach food- water-borne bacterial diseases, surpassing traditional formulations. Further research is needed address burden infections. This review highlights potential revolutionize platforms. We explore their mechanisms action, current applications, emerging trends. The discusses limitations nanovaccines, solutions role artificial intelligence effective accessible nanovaccines infectious diseases.
Language: Английский
Citations
0