Extracellular nanovesicles as neurotherapeutics for central nervous system disorders

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 7, 2024

Introduction The blood-brain barrier (BBB) is a highly selective structure that protects the central nervous system (CNS) while hindering delivery of many therapeutic agents. This presents major challenge in treating neurological disorders, such as multiple sclerosis, where effective drug to brain crucial for improving patient outcomes. Innovative strategies are urgently needed address this limitation.

Language: Английский

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Metabolomic analysis of plant‐derived nanovesicles and extracellular vesicles from Pinellia ternata: insights into a temporary immersion bioreactor system

Physiologia Plantarum, Journal Year: 2024, Volume and Issue: 176(6)

Published: Nov. 1, 2024

Abstract Plant‐derived nanovesicles (PDNVs) and extracellular vesicles (EVs) represent a promising area of research due to their unique properties potential therapeutic applications. Pinellia ternata (P. ternata) is well‐known for its pharmacological but the PDNVs EVs derived from it have been largely understudied. Previous studies shown that Temporary Immersion Bioreactor System (TIBS) plays an important role in controlling plant growth order obtain reproducible PDNVs. were isolated P. plants collected TIBS medium via ultra‐high‐speed differential centrifugation. Particle size, Zeta potentials particle concentrations assessed EVs. Furthermore, non‐targeted metabolomics was used assess metabolic compositional differences between PDNVs, enabling evaluation TIBS's quality control efficacy. Metabolomic profiling revealed 1072 metabolites EVs, including 426 (DMs) distinguishing EVs: 362 DMs positively correlated with 64 EVs; they enriched across 17 KEGG pathways. PCA, PLS‐DA, metabolite sample correlation analyses showed high consistency replicates (PDNVs >0.87, >0.93). This study demonstrated performant system allowing generating ternata. We also highlighted guiding researchers finding bet produce efficient nanodrugs containing compounds.

Language: Английский

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Physical, biochemical, and biological characterization of olive-derived lipid nanovesicles for drug delivery applications

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 18, 2024

Language: Английский

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Vesicles: New Advances in the Treatment of Neurodegenerative Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12672 - 12672

Published: Nov. 26, 2024

Neurodegenerative diseases are characterized by brain lesions that limit normal daily activities and represent a major challenge to healthcare systems worldwide, with significant economic impact. Nanotechnology is the science of manipulating matter at nanoscale, where materials exhibit unique properties significantly different from their larger counterparts. These can be exploited for wide range applications, including medicine. Among emerging therapeutic approaches treatment neurodegenerative diseases, nanotechnologies gaining prominence as promising avenue explore. Here, we review state art biological artificial vesicles in context diseases. Indeed, nanometric structures such extracellular tool disorders due size, biocompatibility, ability transport drugs, proteins, genetic material across blood-brain barrier target specific cells areas. In future, deeper broader synergy between science, bioengineering, biology, medicine, discovery new, increasingly powerful delivery will certainly enable more applied use nanotechnology disorders.

Language: Английский

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