Pathogenesis of depression and the potential for traditional Chinese medicine treatment

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 25, 2024

Depression is a prevalent mental disorder that significantly diminishes quality of life and longevity, ranking as one the primary causes disability globally. Contemporary research has explored potential pathogenesis depression from various angles, encompassing genetics, neurotransmitter systems, neurotrophic factors, hypothalamic-pituitary-adrenal axis, inflammation, intestinal flora, among other contributing factors. In addition, conventional chemical medications are plagued by delayed onset action, persistent adverse effects, restricted therapeutic efficacy. light these limitations, approach traditional Chinese medicine (TCM) gained increasing recognition for its superior effectiveness. Numerous pharmacological clinical studies have substantiated TCM’s capacity to mitigate depressive symptoms through diverse mechanisms. This article attempts summarize mechanisms involved in describe characteristics herbal medicines (including compounded formulas active ingredients) treatment depression. It further evaluates their effectiveness correlating with multifaceted depression, thereby furnishing reference future endeavors.

Language: Английский

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The chronic unpredictable mild stress (CUMS) Paradigm: Bridging the gap in depression research from bench to bedside

Brain Research, Journal Year: 2024, Volume and Issue: 1843, P. 149123 - 149123

Published: Nov. 1, 2024

Language: Английский

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Esketamine alleviates cognitive impairment signs induced by modified electroconvulsive therapy in a depression rat model via the KLF4/p38 MAPK pathway

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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The Extract of Piper nigrum Improves the Cognitive Impairment and Mood in Sleep-Deprived Mice Through the JAK1/STAT3 Signalling Pathway

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1842 - 1842

Published: Feb. 21, 2025

Piper nigrum L. (PN), which contains various bioactive compounds, is a plant with homologous medicine and food. Sleep deprivation (SD) profoundly impacts cognitive function emotional health. However, the mechanisms by PN improves depressive mood induced SD remain unclear. In our study, network pharmacology molecular docking techniques were used to predict potential regulates SD. this 220 compounds identified in PN, 10 core targets screened through pharmacology. Animal experiments showed that ameliorated deficits sleep-deprived mice, upregulated serum activities of superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), downregulated malondialdehyde (MDA) levels. The ELISA assay significantly decreased tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β) Histopathological staining brain tissue demonstrated mitigates SD-induced hippocampal damage, enables hippocampus produce more neurotransmitters, including 5-hydroxytryptamine (5-HT), gamma-aminobutyric acid (GABA), dopamine (DA), reduces glutamate (Glu) RT-qPCR WB analyses further indicated could exert anti-SD effects inhibiting over-activation JAK1/STAT3 signalling pathway. PC12 cell model, reduce inflammation prevent apoptosis, exerting neuroprotective effects. summary, has positive on alleviating symptoms dysfunction

Language: Английский

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Modulation of netrin-1/DCC signaling pathway by Jiawei Kongsheng Zhenzhong Pill improves synaptic structural plasticity in PSD rats

Journal of Pharmacological Sciences, Journal Year: 2025, Volume and Issue: 157(4), P. 242 - 252

Published: Feb. 22, 2025

Jiawei Kongsheng Zhenzhong Pill(JKZP) is based on Pill contained in the Tang Dynasty's "Thousand Golden Prescriptions," which exhibited good anti-ischemic and antidepressant effects previous study. However, its specific post-stroke depression (PSD) mechanism are not clear. This study aimed to investigate of JKZP treatment PSD related mechanisms. The decoction was first analyzed for medicinal chemical composition screened representative components JKZP. Middle cerebral artery occlusion (MCAO) method combined with solitary rearing chronic unpredictable mild stress (CUMS) used establish a rat model PSD, observe behavior synaptic plasticity rats, by detecting mRNA level, protein expression activity Netrin-1/DCC signaling pathway-related proteins. results showed that loganin, β-asarone other pharmaceutical ingredients, have been reported protect against ischemic injury effects. significantly improved depression-like rats damage pyramidal neurons medial prefrontal cortex (mPFC) rats. Moreover, increased density dendritic spines mPFC gap width thickness post-synaptic density, number vesicles. Real-Time quantitative reverse transcription PCR (qRT-PCR), Western blotting, pull-down assays revealed netrin-1, deleted colorectal cancer (DCC), focal adhesion kinase (FAK) expression, elevated p-FAK/FAK ratio, decreased myosin II Ras homolog gene family member A (RhoA-GTP) Taken together, can affect structural remodeling improve depressive manifestations neuronal regulating molecules netrin-1/DCC pathway.

Language: Английский

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Anemarrhena asphodeloides Bunge and Phellodendri Chinensis Cortex inhibits the PTGS2/EP2/cAMP/Epac1 signaling pathway to reduce microglial M1 polarization, thereby blocking chronic stress-induced depression-like behavior

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119792 - 119792

Published: April 1, 2025

Anemarrhena asphodeloides Bunge and Phellodendri Chinensis Cortex (AP) is a synergistic drug combination used to treat depression. However, the molecular mechanism underlying therapeuticeffects of AP requires further elucidation. To investigate potential in treatment depression its action. The model was established by chronic unpredictable mild stress (CUMS) treated with different doses AP. UPLC-Q-TOF-MS/MS network pharmacology methods were analyze composition targets Molecular docking, affinity ultrafiltration (AUF) cellular thermal shift assays (CETSA) techniques interaction between components key targets. therapeutic effects active ingredients explored LPS-induced cell models. ameliorated CUMS-induced despair behaviors, regulate M1 / M2 phenotypic balance microglia reduced neuroinflammation. Then, A total 10 brain identified mPFC CUMS rats. Based on these chemical compositions, PTGS2 found be at core regulatory through analysis. All had good PTGS2, among which Neomangiferin strongest binding capacity. can decrease activity, PGE2 production EP2 expression downstream, reduce inflammatory response. In BV2 cells, regulated imbalance M1/M2 microglia, release pro-inflammatory factors, decreased PEG2, EP2, cAMP, Epac1. improves benefits targeting signaling pathway, thereby promoting wider use

Language: Английский

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Health benefits of medicinal plant natural products via microbiota-mediated different gut axes

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107730 - 107730

Published: April 1, 2025

This review examines the multifaceted roles of medicinal plant natural products in influencing gut microbiota and their subsequent impact on various organ systems through established axes, including gut-brain, gut-liver, gut-heart, gut-lung, gut-kidney axes. Medicinal have exhibited diverse pharmacological activities, modulation composition, enhancement metabolic processes, alleviation inflammation oxidative stress. Evidence suggests that these components can ameliorate conditions such as neurological disorders, syndrome, chronic kidney disease by restoring microbial balance improving barrier integrity. Furthermore, highlights potential to foster beneficial communities improve health, which may lead reduced severity inflammation. By comprehensively analyzing current literature, this provides a foundation for future research aim at exploring therapeutic applications prevention treatment. The findings underscore need further studies elucidate underlying mechanisms action validate clinical efficacy managing modulation.

Language: Английский

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Effects of cryptotanshinone in treatment of polycystic ovary syndrome in rats: a systematic review and meta-analysis

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 16, 2025

Background PCOS is a prevalent endocrine disorder characterized by metabolic dysfunctions, including insulin resistance and hyperandrogenism. Cryptotanshinone, bioactive compound, has shown promise in addressing reproductive abnormalities. However, its therapeutic potential for the management of not been sufficiently investigated. Purpose The aim this study to systematically evaluate efficacy cryptotanshinone treatment PCOS. Methods A comprehensive systematic search was performed across multiple databases, CNKI, Wanfang Data, VIP, PubMed, Web Science, covering studies from their inception through December 2024. methodological quality included assessed using SYRCLE’s Risk Bias tool. Data synthesis statistical analysis were conducted RevMan 5.3 Stata 17 software. Results Seven met inclusion criteria meta-analysis. Treatment with significantly improved several PCOS-related parameters animal models, as compared control group. Notable improvements reductions body weight ( P < 0.00001), ovarian = 0.005), ovaries quotiety 0.0006). Additionally, led significant modulation serum levels f T 0.001), A2 0.02), LH 0.0002), LH/FSH ratio estradiol SHBG 0.0003). underlying mechanism may involve downregulation CYP17 AR mRNA protein expression. Conclusion This meta-analysis provides robust evidence supporting Cryptotanshinone appears restore both functions, regulation weight, morphology, hormone levels, gene holds agent

Language: Английский

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Microbiota–gut–brain axis: Natural antidepressants molecular mechanism

Phytomedicine, Journal Year: 2024, Volume and Issue: 134, P. 156012 - 156012

Published: Aug. 31, 2024

Language: Английский

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The effects and mechanisms of Chai Shao Jie Yu Granules on chronic unpredictable mild stress (CUMS)-induced depressive rats based on network pharmacology

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119268 - 119268

Published: Dec. 19, 2024

Language: Английский

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