Exploring the microbiota-gut-brain axis: impact on brain structure and function

Frontiers in Neuroanatomy, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 12, 2025

The microbiota-gut-brain axis (MGBA) plays a significant role in the maintenance of brain structure and function. MGBA serves as conduit between CNS ENS, facilitating communication emotional cognitive centers via diverse pathways. In initial stages this review, we will examine way how affects neurogenesis, neuronal dendritic morphology, axonal myelination, microglia structure, blood barrier (BBB) permeability, synaptic structure. Furthermore, review potential mechanistic pathways neuroplasticity through influence. short-chain fatty acids (SCFAs) play pivotal MGBA, where they can modify BBB. We therefore discuss SCFAs influence microglia, neuronal, astrocyte function, well their disorders such Alzheimer’s disease (AD), Parkinson’s (PD). Subsequently, technical strategies employed to study interactions, including using germ-free (GF) animals, probiotics, fecal microbiota transplantation (FMT), antibiotics-induced dysbiosis. Finally, particular bacterial strains affect By gaining deeper understanding it may be possible facilitate research into microbial-based pharmacological interventions therapeutic for neurological diseases.

Language: Английский

Efficacy and safety of YOXINTINE for depression: a double-blinded, randomized, placebo-controlled, phase 2 clinical trial

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156204 - 156204

Published: Nov. 14, 2024

Language: Английский