Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis DOI Open Access

Kuanhui Gao,

Lizhi Lv, Zhichao Li

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed cell death pathway distinct from apoptosis, autophagy, necroptosis. Accumulating evidence suggests that ferroptosis is intricately linked to pathogenesis DBJDs, targeting its regulation could be beneficial in managing these conditions. Natural products, known for their anti-inflammatory antioxidant properties, have shown unique advantages preventing potentially through modulating ferroptosis. This article provides an overview latest research on ferroptosis, with focus role DBJDs therapeutic potential natural products this pathway, offering novel insights prevention treatment DBJDs.

Language: Английский

Inhibition of tubular epithelial cells ferroptosis alleviates renal interstitial fibrosis by reducing lipid hydroperoxides and TGF-β/Smad signaling DOI Creative Commons
Yuting Chen, Yue Dai, Yi Huang

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 11, 2025

Ferroptosis is a non-apoptotic form of regulated cell death that involves an imbalance in the homeostasis two elements: iron and lipid hydroperoxides. The accumulation hydroperoxide serves as key trigger for initiating ferroptosis. Recent studies have identified ferroptosis critical pathophysiology contributing to kidney disease progression. However, specific mechanisms underlying role chronic (CKD) not been elucidated. Tubular epithelial cells (TECs) was evaluated unilateral ureteral obstruction (UUO) models TGF-β-treated HK-2 explore relationship between fibrosis. inhibitors (ferrostatin-1) TECs-targeted glutathione peroxidase 4 (GPX4) overexpression vivo vitro were used investigate effect mechanism TECs on fibrosis Our findings indicate persistently activated during various states UUO model. As results, core facilitator renal interstitial UUO. reduction significantly ameliorated maintained structure proximal tubules. Persistent activation effectively aggravated progression through TGF-β/Smad pathway. Inhibiting rescues profibrotic cytokines, thereby alleviating closely related pathway, targeting increasing GPX4 expression could be effective strategy treating CKD. occurrence CKD due regulation, which drives peroxidation hydroperoxide. One primary drivers ferroptosis, peroxidation, further stimulates signaling exacerbates Abbreviations: TFRC, transferrin receptor protein 1; DMT1, divalent metal transporter FPN, ferroportin; ACSL4, acyl-CoA synthetase long-chain family 4; LPCAT3, lysophosphatidylcholine acyltransferase 3; GPX4, CTGF, connective tissue growth factor; PDGFB, platelet-derived factor subunit b; FGF2, fibroblast 2; TECs, tubular cells; CKD, disease. (The figure drawn with BioRender.)

Language: Английский

Citations

1
Ferroptosis in senescence and age-related diseases: pathogenic mechanisms and potential intervention targets DOI
Chang Liu, Jie Pan,

Qi Bao

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 17, 2025

Language: Английский

Citations

1
Dual Targeting of FSP1 and xCT: Potential Mechanism of Anthocyanins in Alleviating Neuronal Ferroptosis in Vascular Dementia DOI
H. G. Tan,

Xinying Fu,

Renyi Yang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156608 - 156608

Published: March 1, 2025

Language: Английский

Citations

0
Improving understanding of ferroptosis: molecular mechanisms, connection with cellular senescence and implications for aging DOI Creative Commons

Diego De León-Oliva,

Diego Liviu Boaru,

Ana Minaya‐Bravo

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e39684 - e39684

Published: Oct. 24, 2024

Language: Английский

Citations

2
Macrophages and the Extracellular Matrix DOI

William Meza-Morales,

Maria Jimenez-Socha, Donald O. Freytes

et al.

Results and problems in cell differentiation, Journal Year: 2024, Volume and Issue: unknown, P. 55 - 87

Published: Jan. 1, 2024

Language: Английский

Citations

1
Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis DOI Open Access

Kuanhui Gao,

Lizhi Lv, Zhichao Li

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed cell death pathway distinct from apoptosis, autophagy, necroptosis. Accumulating evidence suggests that ferroptosis is intricately linked to pathogenesis DBJDs, targeting its regulation could be beneficial in managing these conditions. Natural products, known for their anti-inflammatory antioxidant properties, have shown unique advantages preventing potentially through modulating ferroptosis. This article provides an overview latest research on ferroptosis, with focus role DBJDs therapeutic potential natural products this pathway, offering novel insights prevention treatment DBJDs.

Language: Английский

Citations

0