The role of Chinese herbal medicine in the regulation of oxidative stress in treating hypertension: from therapeutics to mechanisms

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Oct. 29, 2024

Language: Английский

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Harnessing Prebiotics to Improve Type 2 Diabetes Outcomes

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3447 - 3447

Published: Oct. 11, 2024

The gut microbiota, a complex ecosystem of microorganisms in the human gastrointestinal tract (GI), plays crucial role maintaining metabolic health and influencing disease susceptibility. Dysbiosis, or an imbalance has been linked to development type 2 diabetes mellitus (T2DM) through mechanisms such as reduced glucose tolerance increased insulin resistance. A balanced eubiosis, is associated with improved metabolism sensitivity, potentially reducing risk diabetes-related complications. Various strategies, including use prebiotics like inulin, fructooligosaccharides, galactooligosaccharides, resistant starch, pectic oligosaccharides, polyphenols, β-glucan, Dendrobium officinale have shown improve microbial composition support glycemic control T2DM patients. These can directly impact blood sugar levels while promoting growth beneficial bacteria, thus enhancing control. Studies that patients often exhibit decrease butyrate-producing Roseburia Faecalibacterium, increase harmful Escherichia Prevotella. This review aims explore effects different on T2DM, their microbiota composition, potential for personalized dietary interventions optimize management overall outcomes.

Language: Английский

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A Putative Adverse Outcome Pathway Linking Diesel Engine Exhaust with Increased Risks of Metabolism-Related Diseases: A Metabolomics-Based Molecular Epidemiology Study

Environmental Technology & Innovation, Journal Year: 2025, Volume and Issue: 38, P. 104116 - 104116

Published: Feb. 27, 2025

Language: Английский

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GSK621 ameliorates lipid accumulation via AMPK pathways and reduces oxidative stress in hepatocytes in vitro and in obese mice in vivo

Life Sciences, Journal Year: 2025, Volume and Issue: 374, P. 123687 - 123687

Published: May 5, 2025

Language: Английский

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Resistant starch type 1 and 2 macromolecules from giant swamp taro (Cyrtosperma merkusii): A potential solution for lipid metabolism–regulating strategies

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144193 - 144193

Published: May 1, 2025

Language: Английский

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Seabuckthorn polysaccharides mitigate hepatic steatosis by modulating the Nrf-2/HO-1 pathway and gut microbiota

AMB Express, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 9, 2024

Language: Английский

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Metabolic and nutritional effects of vitamin A on growth, lipid metabolism, antioxidant capacity and hepatopancreas health of juvenile mud crab (Scylla paramamosain)

Aquaculture Reports, Journal Year: 2025, Volume and Issue: 41, P. 102703 - 102703

Published: Feb. 22, 2025

Language: Английский

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Gut microbiota-based bioassay for the quality evaluation of different species of Dendrobium and their therapeutic potential in type 2 diabetes

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: May 6, 2025

Abstract Background Dendrobium (DEN) have been utilized as valuable medicinal resource in China used for millennia prevention and treatment of various diseases, particularly diabetes via alteration their disordered gut microbiota. Purpose The current study aimed to differentiate the quality different species DEN an vitro system including microbiota fermentation followed by antioxidative hypoglycemic bioassays. Material methods About 100 g fresh from four (DEN-5 ~ DEN-8) was extracted with 1L boiling water twice 1 h each time centrifugation obtain supernatants aqueous extract. 10 mg/mL extract fermented fecal fluid db/db mice 12, 24 48 h, monitoring changes total polysaccharide polyphenol contents, antioxidative, activities. Additionally, level short chain fatty acids abundance/diversity mixture were monitored GC/MS 16S rRNA, respectively. Moreover, vivo activities DEN-5 DEN-8 at dosage 200 mg/kg once daily 14 days also evaluated mice. Results 8 varied content polysaccharides (0.23–0.61, w/w) (0.008–0.023, w/w). Based on free radical scavenging percentage, ranked DEN-7≈DEN-8 > ≈DEN-6. percentage enzyme inhibition, antihyperglycemic DEN-5≈DEN-6 DEN-7. Hypoglycemic order Further correlation analyses content, SCFAs formation after fermentation, antioxidant activities, found that 1) contents positively correlate generated α-glucosidase inhibitory capacity, α-amylase GLP-1 level; 2) ABTS, DPPH, superoxide anion capacity. Conclusions Our first a novel assess effects indicated correlated effect while activity. Graphical

Language: Английский

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A Novel Camel Milk-Derived Peptide LLPK Improves Glucose-Lipid Metabolism in db/db Mice via PPAR Signaling Pathway

Nutrients, Journal Year: 2025, Volume and Issue: 17(10), P. 1693 - 1693

Published: May 16, 2025

Background: Camel milk is considered to be an important source of bioactive peptides with potential anti-diabetic effects. However, the mechanism by which these active exert their effects not clear. The aim this study was systematically evaluate in vivo Leucine-Leucine-Proline-Lysine (LLPK), a novel dipeptidyl peptidase-4 (DPP-4) inhibitory peptide identified from vitro gastrointestinal digestion product camel milk. Methods: A db/db diabetic mouse model used, and LLPK administered mice at doses 50 mg/kg BW 100 as daily oral gavage for 30 days. on fasting blood glucose (FBG), tolerance test (OGTT), insulin (ITT), serum lipid levels were monitored, possible mechanisms action elucidated using proteomics. Results: results demonstrated that significantly improved symptoms, including FBG, OGTT, ITT, mice. Furthermore, increased glucagon-like 1 (GLP-1) reduced DPP-4 activity observed LLPK-treated group compared control group. Hepatic proteomics indicated metabolism via PPAR signaling pathway, where key targets Scd1, Acox1, Acaa1b, Slc27a1, Acsl1, Ehhadh. Conclusions: In summary, provided new insights into supported development milk-based functional foods or nutraceuticals.

Language: Английский

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Prevention of high-fat/high-sugar diet-induced type 2 diabetes mellitus-associated non-alcoholic fatty liver disease in rats with fermented and raw Rosa roxburghii Tratt (Cili) juice

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 19, 2025

Introduction Rosa roxburghii Tratt (Cili) is a medicinal and edible plant that has hypoglycemic, hypolipidemic, anti-inflammatory antioxidant properties. Methods To compare confirm the potential effects of spontaneous fermented/raw Cili juice (FCJ/RCJ) on type 2 diabetes mellitus (T2DM), constituents FCJ RCJ were characterized compared, high-fat/high-sugar diet (HFD) streptozocin (STZ)-induced T2DM-associated non-alcoholic fatty liver disease (NAFLD) model rats gavaged with FCJ/RCJ (1.5 mL/kg/day) for 20 weeks, after which serum, urine pancreas tissues collected experiments, non-targeted metabolomics transcriptomics analyses conducted, enhanced analysis results transcriptome. Results The findings demonstrated ameliorated hyperglycemia, dyslipidemia, abnormal hepatic function; mitigated lipid accumulation; restored insulin expression levels. These two kinds juices can modulate disorders glucose metabolism, have effects, improve sterol metabolism bile acid homeostasis. Joint indicated antidiabetic in NAFLD are mediated through improvements sensitivity, Notably, stronger effect, whereas preferentially regulates homeostasis mitochondrial β-oxidation. Conclusion vivo experiments conducted this study demonstrate to ameliorate metabolic disorders.

Language: Английский

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