Neurometabolic therapy with Cerebrolysin in patients with sepsis-associated encephalopathy DOI
K.M. Bykova, I. Yu. Kasherininov,

M.D. Lisovoy

et al.

Russian Journal of Anesthesiology and Reanimatology, Journal Year: 2024, Volume and Issue: 6, P. 46 - 46

Published: Jan. 1, 2024

Language: Английский

Pharmacologically inducing anoikis offers novel therapeutic opportunities in hepatocellular carcinoma DOI Open Access
Yumin Wang,

Joshua S Fleishman,

Jinhua Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116878 - 116878

Published: June 5, 2024

Tumor metastasis occurs in hepatocellular carcinoma (HCC), leading to tumor progression and therapeutic failure. Anoikis is a matrix detachment-induced apoptosis, also known as cell death, mechanistically prevents cells from escaping their native extracellular metastasize new organs. Deciphering the regulators mechanisms of anoikis cancer urgently needed treat HCC. Several natural synthetic products induce HCC vivo models. Here, we first briefly summarize current understanding molecular regulation relevant involved metastasis. Then discuss potential pharmacological induction treatment against Finally, key limitations this paradigm propose possible strategies overcome them. Cumulatively review suggests that can be used promising modality

Language: Английский

Citations

5
Development of a ferroptosis-related gene prognostic model and molecular subgroups characterization in sepsis DOI
Yajing Wang,

Zhong-Zheng Bian

Molecular Immunology, Journal Year: 2025, Volume and Issue: 178, P. 1 - 11

Published: Jan. 6, 2025

Language: Английский

Citations

0
Apelin-13 Ameliorates Sepsis-induced Brain Injury by Activating Phosphatase and Tensin Homolog-induced Putative Kinase 1/Parkin-mediated Mitophagy and Modulating Nucleotide-binding Oligomerization Domain-like Receptor Pyrin Domain-Containing 3-driven Pyroptosis in Rats DOI Creative Commons
Fan Jiang, Jingcheng Dong, Yifan Han

et al.

Journal of physiological investigation., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Sepsis is a life-threatening condition that often results in severe brain injury, primarily due to excessive inflammation and mitochondrial dysfunction. This study aims investigate the neuroprotective effects of Apelin-13, bioactive peptide, rat model sepsis-induced injury (SBI). Specifically, we examined role Apelin-13 regulating mitophagy through phosphatase tensin homolog-induced putative kinase 1 (PINK1)/Parkin pathway its impact on nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 (NLRP3) inflammasome-mediated pyroptosis oxidative stress. A sepsis was induced male Sprague–Dawley rats ( n = 110, 200–230 g, 12 weeks old) cecal ligation puncture (CLP). The septic received (20 μg/kg, intravenously), either alone or combined with division inhibitor-1 (Mdv-1), inhibitor, before undergoing CLP surgery. Survival rates were assessed over 72-h period, while cognitive function evaluated using Morris water maze 5 days. Western blotting immunohistochemistry utilized measure expression levels NLRP3, cleaved caspase-1, N-terminal fragment gasdermin D, PINK1, Parkin brains rats. In addition, enzyme-linked immunosorbent assays conducted evaluate markers stress inflammatory responses samples. significantly improved survival mitigated treatment enhanced PINK1/Parkin-mediated suppressed NLRP3 inflammasome activation, leading reduction pyroptosis, inflammation, Inhibition by Mdv-1 reversed protective Our findings suggest provides neuroprotection modulating inhibiting pyroptosis. These highlight potential as therapeutic strategy for SBI.

Language: Английский

Citations

0
Sepsis: the evolution of molecular pathogenesis concepts and clinical management DOI Creative Commons

Zhongxue Feng,

Lijun Wang, Jing Yang

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: Feb. 23, 2025

Abstract The mortality rate of sepsis is approximately 22.5%, accounting for 19.7% the total global mortality. Since Lewis Thomas proposed in 1972 that “it our response makes disease (sepsis)” rather than invading microorganisms, numerous drugs have been developed to suppress “overwhelming” inflammatory response, but none them has achieved desired effect. Continued failure led investigators question whether deaths septic patients are indeed caused by uncontrolled inflammation. Here, we review history clinical trials based on evolving concepts pathogenesis over past half century, summarize factors these historical and prerequisites success future drugs, propose basic principles preclinical research ensure successful translation. strategy targeting like attempting eliminate invaders suppressing host's armed forces, which logically untenable. Sepsis may not be complex; rather, result a fight microbes when force an pathogen overwhelms defenses. Thus, strengthening body's defense forces instead correct overcome sepsis.

Language: Английский

Citations

0
Roles of anoikis in hepatocellular carcinoma therapy and the assessment of anoikis-regulatory molecules as therapeutic targets DOI
Hongyu Wang, Ya‐Wen Yang, Gan Zhang

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

Citations

0
Ferroptosis targeting offers a Therapeutic Target for Septic cardiomyopathy DOI
Ping Zhou, Mengxue Liu, Tao Lv

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102930 - 102930

Published: April 25, 2025

Language: Английский

Citations

0
Carrageenan-ferrocene-eicosapentaenoic acid composite hydrogel induce ferroptosis and apoptosis for anti-tumor recurrence and metastasis DOI
Xiangyan Chen, Tianze Jiang,

Yantao Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133942 - 133942

Published: July 16, 2024

Language: Английский

Citations

3
Electron-reservoir applications of ferrocenes and other late transition-metal sandwich complexes: Flow batteries, sensing, catalysis, and biomedicine DOI
Tiansheng Wang, Didier Astruc

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 524, P. 216300 - 216300

Published: Nov. 9, 2024

Language: Английский

Citations

2
Dichloroacetate Prevents Sepsis Associated Encephalopathy by Inhibiting Microglia Pyroptosis through PDK4/NLRP3 DOI Creative Commons

Xuliang Huang,

Yuhao Zheng, Nan Wang

et al.

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 23, 2024

Dichloroacetate (DCA), a pyruvate dehydrogenase kinase inhibitor, is often used to treat lactic acidosis and malignant tumors. Increasing studies have shown that DCA has neuroprotective effects. Here, we explored the role mechanism of in Sepsis associated encephalopathy (SAE). Single-cell analysis was determine important PDK4 SAE identify cell type. GO GSEA were correlation between pyroptosis. Through LPS + ATP stimulation, microglia pyroptosis model established observe expression level intracellular pyroptosis-related proteins under intervention, further detect changes ROS JC-1. Additionally, co-culture environment neuron simply constructed evaluate effect on activated microglia-mediated neuronal apoptosis. Finally, Novel object recognition test Morris water maze explore cognitive function mice from different groups after intervention. Based above experiments, this study concludes can improve ratio peripheral central M1 macrophages, inhibit NLRP3-mediated through mitochondrial membrane potential (MMP). reduce death caused by mice. In SAE, may be candidate drug for treatment neuroinflammation.

Language: Английский

Citations

1
NLRP3 targets HMGB1 to exacerbate the pyroptosis of canine corneal epithelial cells infected with Staphylococcus pseudintermedius DOI
Zhihao Wang, Long Guo, Chengcheng Zhu

et al.

Experimental Eye Research, Journal Year: 2024, Volume and Issue: unknown, P. 110096 - 110096

Published: Sept. 1, 2024

Language: Английский

Citations

1