Dietary phytochemicals alleviate the premature skin aging: A comprehensive review DOI Creative Commons
Harpreet Singh,

Yusuf Kamal,

Jessica Pandohee

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 199, P. 112660 - 112660

Published: Dec. 19, 2024

Skin aging, often called as premature skin is the hastened deterioration of resulting from multiple factors, including UV radiation, environmental contaminants, inadequate nutrition, stress, etc. Dietary phytochemicals, present in fruits, vegetables, and other plant-derived meals, have gained interest due to their efficiency eradicate free radicals lowering release inflammatory mediators which accounts for aging. Several dietary i.e., carotenoids, polyphenols, flavonoids, terpenes, alkaloids, phytosterols, etc., exhibited potential anti-oxidant, anti-inflammatory, suppression damage, promote collagen synthesis. In addition, phytochemicals include sulfur, various foods safeguard against oxidative stress inflammation. Thus, this article delves into comprehension investigated alleviate The further highlights specific sources, bioavailability, mechanisms, context safeguarding manuscript a systematic available literature on aging database, PubMed, ScienceDirect, Google Scholar using keywords, "dietary phytochemicals", "nutraceuticals", "skin aging" via Boolean operator, "AND". guidelines presented unique summarization broad reader understand inclusion functional foods, nutrients, supplements, prevent utilization has shown promising avenue preventing however, future perspectives challenges such should be comprehended clinical investigations.

Language: Английский

Polysaccharide-based chondroitin sulfate macromolecule loaded hydrogel/scaffolds in wound healing- A comprehensive review on possibilities, research gap, and safety assessment DOI
Shubhrajit Mantry,

Ashutosh Behera,

Shaktiprasad Pradhan

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135410 - 135410

Published: Sept. 6, 2024

Language: Английский

Citations

4
Diabetic Nephropathy: Pathogenesis, Mechanisms, and Therapeutic Strategies DOI

Shivangi Dwivedi,

Mukesh Singh Sikarwar

Hormone and Metabolic Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Diabetic nephropathy represents a predominant etiology of end-stage renal disease (ESRD) on global scale, significantly impacting the morbidity and mortality rates individuals with diabetes. The primary objective this analysis is to furnish comprehensive examination etiology, fundamental mechanisms, treatment modalities for DN. development DN stems from multitude factors, encompassing intricate interplay involving metabolic irregularities induced by hyperglycemia, alterations in hemodynamics, inflammatory responses, oxidative stress, genetic susceptibility. Principal mechanisms encompass generation advanced glycation end products (AGEs), activation protein kinase C (PKC), overexpression renin-angiotensin-aldosterone system (RAAS). These processes precipitate glomerular hyperfiltration, hypertrophy, eventually, fibrosis scarring parenchyma. Initially, hyperglycemia triggers mesangial proliferation thickening basement membrane incipient stages DN, subsequently leading progressive sclerosis tubulointerstitial fibrosis. Inflammatory cascades, notably cytokines like TGF-β NF-κB, play pivotal roles advancement fostering accumulation extracellular matrix Inflammation pathways, particularly those essential diabetic progression stimulating presence worsened dysfunctional mitochondria, contributes further injury via lipid peroxidation DNA damage. Current therapeutic approaches concentrate optimizing glycemic control, controlling hypertension, suppressing system. Among antihypertensive medications, ACE inhibitors angiotensin II receptor blockers are crucial decelerating advancement.

Language: Английский

Citations

4
Neuroprotective Effect Of Thymus Vulgaris On Paraquat Induced Parkinson’s Disease DOI
Naheed Akhter,

Iqra Rafiq,

Amer Jamil

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151740 - 151740

Published: April 1, 2025

Language: Английский

Citations

0
Naringin attenuates angiotensin II induced cardiac hypertrophy by inhibiting carbonic anhydrase II DOI Creative Commons

Mahendra Mahadevaswamy,

G. P. Suchitha,

S. R. Pavan

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 6, 2025

Nutraceuticals exert a series of health benefits, including protection against cardiovascular diseases. In this study, naringin, naringenin, and quercetin were tested for their safety efficacy in ameliorating angiotensin (Ang) II-induced cardiac hypertrophy through carbonic anhydrase II (CA-II) inhibition. silico molecular docking MD simulations exhibited that naringin strongly binds CA-II with score -9.55 kcal/mol hydrogen bonding energy -6.07 kcal/mol. Naringin formed stable bond interactions Asn62, Trp5, N-acetyl His4 via catalytic water molecule, continuous interaction major bridge His4, Trp5. Moreover, effectively inhibited activity an IC50 value 82.99 ± 4.92 nM, followed by naringenin quercetin. Of note, all the nutraceuticals found to be safe as evident from cell viability assays. Further, attenuated hypertrophy, indicated reductions Ang increases surface area H9c2 cardio myoblasts (165.6 1.26% vs. 109.8 1.88% + naringin), Furthermore, significantly (191.77 7.69% 120.16 5.52% naringin) suppressed Na+/H+ exchanger 1 (NHE1) protein expression. Besides, CA-II, NHE1, Na+/Ca2+ (NCX1), angiotensin-converting enzyme (ACE1) mRNA Collectively, when compared myoblast activity, NHE1 The naringin-mediated attenuation might inhibition suppression NCX1.

Language: Английский

Citations

0
Synthesis of zinc oxide nanoparticles (ZnO NPs) via modified chemical method for potential effectiveness against SW982 cells in osteoarthritis management DOI
Sourav Mohanto, Mohammed Gulzar Ahmed, Adrija Bhunia

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114633 - 114633

Published: May 1, 2025

Language: Английский

Citations

0
Preparation and anti-tumor activity of paclitaxel silk protein nanoparticles encapsulated by biofilm DOI
Yating Ji,

Junxu Hao,

Tao Xu

et al.

Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: 29(6), P. 627 - 638

Published: July 2, 2024

In order to overcome the poor bioavailability of paclitaxel (PTX), in this study, self-assembled silk fibronectin nanoparticles (PTX-SF-NPs) were encapsulated with outer membrane vesicles Escherichia coli (E. coil), and biofilm-encapsulated (OMV-PTX-SF-NPs) prepared by high-pressure co-extrusion, size zeta potential OMV-PTX-SF-NPs measured. The antitumor effects evaluated cellular pharmacodynamic assays, pharmacokinetic experiments performed. results showed that hydrophobic forces hydrogen bonding played a major role interaction between filipin proteins, was 199.8 ± 2.8 nm, -17.8 1.3 mv. vivo assays demonstrated possessed promising effect. Pharmacokinetic AUC0-∞ 5.314 0.77, which much larger than free PTX, 0.744 0.14. Overall, we have successfully constructed stable oral formulation sustained-release effect, is able effectively increase paclitaxel, improve activity, reduce adverse effects.

Language: Английский

Citations

2
Non-isocyanate polyurethane-co-polyglycolic acid electrospun nanofiber membrane wound dressing with high biocompatibility, hemostasis, and prevention of chronic wound formation DOI Creative Commons
Fan Ge, Tong Wan,

Linglin Kong

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33693 - e33693

Published: June 26, 2024

The prevention of chronic wound formation has already been a primary subject in management, particularly for deep wounds. electrospun nanofiber membranes hold tremendous potential the wounds due to their micro/nano pore structures. Currently, many natural and synthetic materials have utilized fabrication membranes. However, striking balance between structural stability biocompatibility remains challenging. It is necessary not only ensure long-term durability but also enhance alleviating patients' suffering. In this study, we reported membrane dressing with excellent mechanical properties, which treatment basal material chosen preparation was co-polyester (NI-LPGD5) synthesized by non-isocyanate polyurethane (NIPU) polyglycolic acid dihydroxy structure (LPGD—synthesized from glycolic neopentyl glycol). Moreover, curcumin added as bioactive substance pro-healing effect dressings. physicochemical properties prepared were characterized through various tools. Our results demonstrated that NI-LPGD5 co-polymer can be into smooth fibers. Meanwhile, curcumin-loaded (Cur/NI-LPGD5) exhibited favorable microscopic morphology. fabricated suitable outstanding hygroscopic-swelling rate water vapor transmittance. Besides, vitro cell culturing, cells on maintained maximum viability. vivo healing further animal experiments. experimental showed effectively prevented forming promoted granulation tissue growth without replacing throughout process. We found these could promote expression related biomarkers accelerate healing, Cur/NI-LPGD5 membrane. conclusion, possess promising bioactivity. As result, it significant reducing frequency changes.

Language: Английский

Citations

2
Development of optimized resveratrol/piperine-loaded phytosomal nanocomplex for isoproterenol-induced myocardial infarction treatment DOI

Thriveni Raunak Salian,

Nadira Noushida, Sourav Mohanto

et al.

Journal of Liposome Research, Journal Year: 2024, Volume and Issue: 34(4), P. 640 - 657

Published: July 12, 2024

Cardiovascular disease is a significant and ever-growing concern, causing high morbidity mortality worldwide. Conventional therapy often very precarious requires long-term usage. Several phytochemicals, including Resveratrol (RSV) Piperine (PIP), possess cardioprotection may be restrained in clinical settings due to inadequate pharmacokinetic properties. Therefore, this study strives develop an optimized RSV phytosomes (RSVP) co-loaded with PIP (RPP) via solvent evaporation method using Box-Behnken design enhance the properties isoproterenol-induced myocardial infarction (MI). The particle size (20.976 ± 0.39 176.53 0.88 nm), zeta potential (−33.33 1.5 −48.7 1.6 mV), drug content (84.57 0.9 87.16 0.6%), %EE (70.56 0.7 67.60 0.57%) of prepared RSVP RPP, respectively demonstrated enhanced solubility control release diffusion media. oral administration RPP infarction-induced rats exhibited (p < 0.001) improvement heart rate, ECG, biomarker, anti-oxidant levels, no inflammation than pure RSV. assessment on healthy Wistar prolonged circulation (>24 h) compared free drug/s. ability penetrate bio-membranes enter systemic renders them more promising strategy for mitigating MI.

Language: Английский

Citations

1
Dietary phytochemicals alleviate the premature skin aging: A comprehensive review DOI Creative Commons
Harpreet Singh,

Yusuf Kamal,

Jessica Pandohee

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 199, P. 112660 - 112660

Published: Dec. 19, 2024

Skin aging, often called as premature skin is the hastened deterioration of resulting from multiple factors, including UV radiation, environmental contaminants, inadequate nutrition, stress, etc. Dietary phytochemicals, present in fruits, vegetables, and other plant-derived meals, have gained interest due to their efficiency eradicate free radicals lowering release inflammatory mediators which accounts for aging. Several dietary i.e., carotenoids, polyphenols, flavonoids, terpenes, alkaloids, phytosterols, etc., exhibited potential anti-oxidant, anti-inflammatory, suppression damage, promote collagen synthesis. In addition, phytochemicals include sulfur, various foods safeguard against oxidative stress inflammation. Thus, this article delves into comprehension investigated alleviate The further highlights specific sources, bioavailability, mechanisms, context safeguarding manuscript a systematic available literature on aging database, PubMed, ScienceDirect, Google Scholar using keywords, "dietary phytochemicals", "nutraceuticals", "skin aging" via Boolean operator, "AND". guidelines presented unique summarization broad reader understand inclusion functional foods, nutrients, supplements, prevent utilization has shown promising avenue preventing however, future perspectives challenges such should be comprehended clinical investigations.

Language: Английский

Citations

0