Stem cells and bio scaffolds for the treatment of cardiovascular diseases: new insights
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 12, 2024
Mortality
and
morbidity
from
cardiovascular
diseases
are
common
worldwide.
In
order
to
improve
survival
quality
of
life
for
this
patient
population,
extensive
efforts
being
made
establish
effective
therapeutic
modalities.
New
treatment
options
needed,
it
seems.
addition
treating
diseases,
cell
therapy
is
one
the
most
promising
medical
platforms.
One
approaches
in
area
stem
therapy.
biology,
multipotent
cells
pluripotent
divided
into
two
types.
There
evidence
that
could
be
used
as
a
approach
based
on
multiple
lines
evidence.
The
effectiveness
therapies
humans
has
been
studied
several
clinical
trials.
spite
challenges
associated
with
therapy,
appears
resolving
them
may
lead
disease
patients.
This
an
approach.
By
mounting
these
biological
scaffolds,
their
effect
can
enhanced.
Language: Английский
Bone Tissue Engineering: From Biomaterials to Clinical Trials
Advances in experimental medicine and biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Language: Английский
Bioactive Functionalized Chitosan Thermo‐Responsive Hydrogels as Promising Platforms for Therapeutic, Regenerative Oral, and Maxillofacial Applications
Meshari Alkandari,
No information about this author
Paritosh Barai,
No information about this author
Gamal Abdel Nasser Atia
No information about this author
et al.
Biotechnology Journal,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 1, 2025
ABSTRACT
Due
to
their
superior
physicochemical
features,
chitosan
thermosensitive
hydrogels
are
multipurpose
platforms
that
frequently
used
in
the
biomedical
industry.
Many
investigations
have
been
conducted
recently
modify
pore
dimensions,
expansion,
biodegradability,
stimulus‐reaction
characteristics,
and
other
characteristics
order
better
tailor
them
complex
craniofacial
tissues.
They
focus
of
various
studies
attempted
load
biological
cargos
for
therapeutic
regenerative
uses
oro‐facial
This
article
assesses
utility
advancements
hydrogel‐based
pharmaceutical
delivery
devices
management
disorders
such
as
dental
caries,
endodontic
diseases,
periodontitis,
temporomandibular
disorders,
mucosal
cancer,
so
forth.
Language: Английский
Regenerative Medicine in Plastic Surgery: The Role of Stem Cells and Bioprinting
Regenesis repair rehabilitation.,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Language: Английский
Evaluation of Anti-Inflammatory and Antibacterial Properties of Photo-Thermal Hydrogel as Dual Functional Platform for Management of Periodontitis
Zhihong Mai,
No information about this author
Y.S. Mai,
No information about this author
Xianxian Huang
No information about this author
et al.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 2923 - 2934
Published: March 1, 2025
Background:
Periodontitis,
one
of
the
most
common
oral
diseases
caused
by
bacterial
infection
which
affects
gums,
periodontal
ligament
and
alveolar
bone,
is
a
leading
cause
tooth
loss
in
adults.
Current
clinical
treatments,
such
as
scaling
or
antibiotics,
often
result
incomplete
biofilm
removal
can
contribute
to
drug
resistance.
Methods:
To
address
these
limitations,
nanozyme
comprising
platinum,
copper,
selenium
was
developed,
then
incorporated
into
thermoresponsive
hydrogel.
Results:
When
applied
pockets
exposed
808
nm
laser
irradiation,
hydrogel
became
soft,
dissolving
release
nanozyme.
This
demonstrated
superoxide
dismutase
(SOD)-like
catalase
(CAT)-like
activity,
reducing
excess
reactive
oxygen
species
(ROS)
while
displaying
strong
antibacterial
anti-inflammatory
effects.
Conclusion:
photothermal
showed
excellent
biocompatibility
has
potential
overcome
challenges
current
periodontitis
treatments.
Keywords:
thermosensitive,
therapy,
hydrogel,
Language: Английский
Prospective and challenges of locally applied repurposed pharmaceuticals for periodontal tissue regeneration
Mohammad El-Nablaway,
No information about this author
Fatema Rashed,
No information about this author
Ehab S. Taher
No information about this author
et al.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Nov. 13, 2024
Periodontitis
is
a
persistent
inflammatory
condition
that
causes
periodontal
ligament
degradation,
pocket
development,
and
alveolar
bone
destruction,
all
of
which
lead
to
the
breakdown
teeth’s
supporting
system.
triggered
by
accumulation
various
microflora
(especially
anaerobes)
in
pockets,
release
toxic
substances
digestive
enzymes
stimulate
immune
can
be
efficiently
treated
using
variety
techniques,
both
regional
systemic.
Effective
therapy
dependent
on
lowering
microbial
biofilm,
minimizing
or
eradicating
pockets.
Nowadays,
local
drug
delivery
systems
(LDDSs)
as
an
adjuvant
phase
I
attractive
option
since
it
controls
release,
resulting
improved
efficacy
lesser
adverse
reactions.
Choosing
right
bioactive
agent
mode
foundation
efficient
disease
management
approach.
The
objective
this
paper
shed
light
issue
successful
regeneration,
drawbacks
currently
implemented
interventions,
describe
potential
locally
delivered
repurposed
drugs
tissue
regeneration.
Because
multiple
etiology
periodontitis,
patients
must
get
customized
treatment
with
primary
goal
infection
control.
Yet,
not
always
replace
lost
tissues,
becomes
more
challenging
defect
gets
worse.
Pharmaceutical
repurposing
offers
viable,
economical,
safe
alternative
for
non-invasive,
predictable
This
article
clears
way
front
researchers,
decision-makers,
pharmaceutical
companies
explore
potential,
effectiveness,
efficiency
pharmaceuticals
generate
effective,
topical
preparations
Language: Английский