Trimethylamine N-oxide, S-equol, and indoxyl sulfate inflammatory microbiota players in ocular Behçet’s disease DOI Creative Commons
Sermal Arslan, Mehmet Kaan Kaya, Suna Aydın

et al.

Turkish Journal of Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract Objectives The aims of the study were to assess levels serum TMAO, S-equol, and indoxyl sulfate in subjects with ocular active Behçet’s disease (OABD) inactive (OIBD). Methods involved 22 patients OABD, OIBD, thwentythree control participants. 5 mL venous blood was taken from measured using ELISA method. Results When compared TMAO group, participants OABD OIBD considerably greater (p<0.05). Similarly, when S-equol significantly higher Additionally, amounts Conclusions It first time shown that microbiota molecules could have an impact on (BD) pathogenesis. measuring these addition BD Ocular Attack Score 24 (BOS24) might offer advice medical professionals regarding diagnosis treatment illness.

Language: Английский

TMAO accelerates cellular aging by disrupting endoplasmic reticulum integrity and mitochondrial unfolded protein response DOI Creative Commons
Fahimeh Varzideh,

Emanuele Farroni,

Urna Kaunsakar

et al.

Cellular and Molecular Life Sciences, Journal Year: 2025, Volume and Issue: 82(1)

Published: Jan. 21, 2025

Language: Английский

Citations

0
Role of Microbiota‐Derived Metabolites in Prostate Cancer Inflammation and Progression DOI Open Access
Pradeep Kumar Rathinavelu, Anil Kumar, Virendra Kumar

et al.

Cell Biochemistry and Function, Journal Year: 2025, Volume and Issue: 43(2)

Published: Jan. 31, 2025

Prostate cancer (PCa) is the most commonly detected malignancy in men worldwide. PCa a slow-growing with absence of symptoms at early stages. The pathogenesis has not been entirely understood including key risk factors related to development like diet and microbiota derived metabolites. Microbiota may influence host's immunological responses, inflammatory metabolic pathways, which be crucial for metastasis. Similarly, short-chain fatty acids, methylamines, hippurate, bile other metabolites generated by have potential roles inflammation progression cancer. Most studies focused on role their pathways involved chronic inflammation, tumor initiation, proliferation, progression. In summary, review discusses microbial-derived metabolite-built strategies PCa.

Language: Английский

Citations

0
Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies DOI Creative Commons
Lorenzo Drago, Luigi R. De La Motte,

Loredana Deflorio

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

MicroRNAs (miRNAs) and the gut microbiome are key regulators of human health, with emerging evidence highlighting their complex, bidirectional interactions in chronic diseases. miRNAs, influence gene expression can modulate composition function microbiome, impacting metabolic immune processes. Conversely, affect host miRNA expression, influencing inflammatory pathways disease susceptibility. This systematic review examines recent studies (2020–2024) focusing exclusively on subjects, selected through rigorous inclusion exclusion criteria. Studies were included if they investigated interaction between miRNAs context gastrointestinal diseases, obesity, autoimmune cognitive neurodegenerative disorders, autism. In vitro , vivo silico analyses excluded to ensure a strong translational focus pathophysiology. Notably, stable abundant patients, as promising biomarkers microbiome-driven inflammation. provides an overview regulatory effects bacterial strains, associations specific It also explores therapeutic advances potential miRNA-based therapies restore microbial balance reduce

Language: Английский

Citations

0
Inverted U-shape association between urine equol levels and cancer: a national population-based cross-sectional study DOI Creative Commons

Jufa Li,

Jing Lv,

Yuwei Zhang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 28, 2025

Equol, a naturally occurring phytoestrogen derived from the fermentation of soy and soy-based products by gut bacteria, is recognized for its diverse health benefits. While there speculation about association with cancer prevention, scientific community has yet to reach consensus due variability in research findings. Our study aims shed light on this topic examining correlation between urine equol concentrations risk among American population. The National Health Nutrition Examination Survey (NHANES) national survey U.S. civilians which participants are enrolled database sample questionnaire. This included 2797 Americans aged 40 years older NHANES (2005–2010). relationship concentration was analysed using weighted logistic regression models, stratified analysis, smoothed curve fitting threshold effect analysis were also performed. Among our study, 390 individuals received diagnosis. findings indicate positive levels cancer. Notably, highest quartile excretion exhibited significantly elevated cancer, 25.4% increase compared those lowest (POR = 1.254, 95% CI: 1.252, 1.256), after fully adjusting confounders. Similar results observed other adjusted models. A non-linear shape an inverted U-shape can be fitting, inflection point 25.5. Urinary below 25.5 ng/ml positively associated risk, while above showed slight negative trend risk. However, further prospective studies needed provide more robust evidence confirmed large clinical trials.

Language: Английский

Citations

0
Factors Affecting Gut Microbiota and Its Relationship with Cardiovascular Diseases: A Narrative Review DOI Creative Commons

Hossein Karballaei Mirzahosseini,

Mostafa Esmaeili,

Ali Mirakhorli

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 16, 2025

Context: The estimated population of microorganisms inhabiting the gastrointestinal tract is thought to exceed 1014, with a total weight approximately 2 kg. This accumulation microbiota indicates that number bacterial cells ten times greater than human cells, and gene content exceeds genome by more hundredfold. These are essential for maintaining health, having evolved over millions years. They influence vital processes in life, such as digestion regulation immune system. gut (GM) can be viewed dynamic environmental factor, its composition shaped host genetics, dietary patterns, hygiene practices, lifestyle choices. variability positions it potential therapeutic target cardiovascular disease (CVD) myocardial infarction (MI). Evidence Acquisition: present study review factors affecting intestinal relationship heart diseases. To ensure identification most relevant studies, common databases, including PubMed, Scopus, Web Science, were searched using terms "Gut dysbiosis", "Cardiovascular disease", "Probiotics", "prebiotics". articles abstracts obtained from search then reviewed. Results: Dysbiosis plays significant role onset progression atherosclerosis CVD. Microbiota-derived short-chain fatty acids (SCFAs) crucial development blood pressure. Alterations have been linked dysfunctions lipid metabolism, reduced levels high-density lipoprotein (HDL) plasma patients GM affect efficiency energy extraction sources, thereby impacting likelihood developing obesity through inflammation metabolism. Conclusions:

Language: Английский

Citations

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Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health DOI Creative Commons
Eugenio Caradonna, Francesca Abate, Elisabetta Schiano

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 220 - 220

Published: March 24, 2025

The intestinal microbiota, hosting trillions of microorganisms that inhabit the gastrointestinal tract, functions as a symbiotic organism plays crucial role in regulating health by producing biologically active molecules can enter systemic circulation. Among them, trimethylamine-N-oxide (TMAO), an organic compound derived from dietary sources and microbial metabolism, has emerged critical biomarker linking diet, gut host metabolism to various pathological conditions. This comprehensive review highlights TMAO’s biosynthesis, physiological functions, clinical significance, focusing on its mechanistic contributions cardiovascular neurodegenerative diseases. Notably, TMAO-mediated pathways include endothelial dysfunction, inflammation via NLRP3 inflammasome activation, cholesterol disruption, which collectively accelerate atherosclerosis disease progression. Nonetheless, this work underscores innovative potential targeting TMAO through dietary, nutraceutical, microbiota-modulating strategies mitigate effects, marking transformative approach prevention management TMAO-related disorders.

Language: Английский

Citations

0
Ethanol-induced changes to the gut microbiome compromise the intestinal homeostasis: a review DOI Creative Commons
Konrad Sosnowski, Adam Przybyłkowski

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 3, 2024

The intestine is the largest organ in terms of surface area human body. It responsible not only for absorbing nutrients but also protection against external world. gut microbiota essential maintaining a properly functioning intestinal barrier, primarily through producing its metabolites: short-chain fatty acids, bile and tryptophan derivatives. Ethanol overconsumption poses significant threat to health. Not does it damage epithelium, but, maybe foremostly, changes microbiome. Those ethanol-driven shift metabolome, depriving host protective effect physiological has. This literature review discusses impact ethanol consumption on gut, microbiota, providing comprehensive overview mechanisms which disrupts homeostasis discussing potential avenues new therapeutic intervention.

Language: Английский

Citations

3
Gut–brain axis and brain health: modulating neuroinflammation, cognitive decline, and neurodegeneration DOI

Anchal Trisal,

Ishika Singh,

Geetika Garg

et al.

3 Biotech, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 27, 2024

Language: Английский

Citations

3
Interplay of Oxidative Stress, Gut Microbiota, and Nicotine in Metabolic-Associated Steatotic Liver Disease (MASLD) DOI Creative Commons
Irene Mignini,

Linda Galasso,

Giulia Piccirilli

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1532 - 1532

Published: Dec. 14, 2024

Oxidative stress has been described as one of the main drivers intracellular damage and metabolic disorders leading to syndrome, a major health problem worldwide. In particular, free radicals alter lipid metabolism promote accumulation in liver, existing hepatic facet dysfunction-associated steatotic liver disease (MASLD). Recent literature highlighted how nicotine, especially if associated with high-fat diet, exerts negative effect on induction progression MASLD by upregulating inflammation increasing oxidative stress, abdominal fat lipolysis, lipogenesis. Moreover, considerable evidence shows central role intestinal dysbiosis pathogenesis impact nicotine-induced gut microbiome. This results an intricate network which stands at intersection point between microbiome, MASLD. The aim this review is delve into molecular mechanisms linking tobacco smoking MASLD, focusing microbiota modifications their development.

Language: Английский

Citations

1
Short sleep time has a greater impact on the gut microbiota of female DOI
Fangfang Gao,

Linwei Ding,

Guankui Du

et al.

Sleep And Breathing, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 28, 2024

Language: Английский

Citations

0