Fructose-mediated AGE-RAGE axis: approaches for mild modulation DOI Creative Commons
Halyna Semchyshyn

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 4, 2024

Fructose is a valuable and healthy nutrient when consumed at normal levels (≤50 g/day). However, long-term consumption of excessive fructose elevated endogenous production can have detrimental health impacts. Fructose-initiated nonenzymatic glycation (fructation) considered as one the most likely mechanisms leading to generation reactive species propagation processes. In later stages glycation, poorly degraded advanced products (AGEs) are irreversibly produced accumulated in organism an age- disease-dependent manner. Fructose, along with various products-especially AGEs-are present relatively high concentrations our daily diet. Both exogenous AGEs exhibit wide range biological effects, which be associated following: (1) efficient sources

Language: Английский

Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil DOI
Zhongming Yang, Carlos L. Céspedes, Zhongguo Yang

et al.

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

Citations

6
6-PPD triggered lipid metabolism disorder and inflammatory response in larval zebrafish (Danio rerio) by regulating PPARγ/NF-κB pathway DOI
Qiuhui Qian,

Ji Wu,

Cuizhen Wang

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125785 - 125785

Published: Feb. 1, 2025

Language: Английский

Citations

0
Aflatoxin B1 Exposure Suppresses the Migration of Dendritic Cells by Reshaping the Cytoskeleton DOI Open Access

Kaiyi Tang,

Jane Tian, Yujun Xu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1725 - 1725

Published: Feb. 18, 2025

Exposure to Aflatoxin B1 (AFB1) is considered a significant risk factor for human diseases, including the immune function impairment of cells. Dendritic cells (DCs), as essential antigen-presenting cells, play pivotal role in bridging innate and adaptive immunity. However, impact AFB1 exposure on DCs has not been fully elucidated. In this study, we investigated effects migration ability its underlying action model. Initially, observed that inhibited survival altered their cellular morphology. Further investigation revealed promotes cell adhesion inhibits DC by modulating expression molecules. Additionally, our findings indicated cytoskeletal remodeling plays crucial these processes. Experimental techniques such immunofluorescence RNA sequencing confirmed regulates cytoskeleton-related genes. Moreover, found perturbation gene profile through associated with communication. Collectively, study demonstrate can disrupt cytoskeleton- adhesion-related molecules DCs, thereby altering morphology migration. These insights could provide new perspectives further understanding immunosuppressive developing therapeutic strategies diseases exposure.

Language: Английский

Citations

0
Therapeutic Prospects of Undaria pinnatifida Polysaccharides: Extraction, Purification, and Functional Activity DOI Creative Commons
Kit‐Leong Cheong, Wenjie Chen, Min Wang

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(4), P. 163 - 163

Published: April 8, 2025

Undaria pinnatifida, an edible brown seaweed that is widely consumed in East Asia, has gained increasing recognition for its health benefits. Among bioactive compounds, polysaccharides have attracted significant attention due to their diverse biological activity. This review provides a comprehensive overview of recent advancements the extraction, purification, structural characterization, and bioactivity U. pinnatifida polysaccharides. We discuss state-of-the-art extraction techniques, including ultrasound-assisted, microwave-assisted, enzyme-assisted as well purification strategies such membrane separation chromatographic methods. Furthermore, we highlight potential activity, antioxidant, immunomodulatory, anticancer, gut health-promoting, anti-hyperglycemic effects, along with underlying mechanisms action. By summarizing latest research, this aims provide valuable insights into development application functional foods pharmaceuticals.

Language: Английский

Citations

0
Exploring the Immunomodulatory Mechanisms of Osmunda japonica Thunb Polysaccharides: Activation of MAPK and NF-κB Signaling Pathways DOI
Xiaochen Liu, Rui Xu, Yuting Liao

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105695 - 105695

Published: Dec. 1, 2024

Language: Английский

Citations

1
Multiple Mechanisms of Action of Sulfodyne®, a Natural Antioxidant, against Pathogenic Effects of SARS-CoV-2 Infection DOI Creative Commons
Paul‐Henri Roméo, Laurine Conquet,

Sébastien Messiaen

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1083 - 1083

Published: Sept. 4, 2024

Few therapeutic options are available to treat COVID-19. The KEAP1/NRF2 pathway, the major redox-responsive has emerged as a potential target for COVID-19 it regulates redox homeostasis and inflammation that altered during SARS-CoV-2 infection. Here, we characterized effects of NRF2-agonist Sulfodyne®, stabilized natural Sulforaphane, in cellular animal models In pulmonary or colonic epithelial cell lines, Sulfodyne® elicited more efficient inhibition replication than NRF2-agonists DMF CDDO. This antiviral activity was not dependent on NRF2 but associated with regulation several metabolic pathways, including ER stress mTOR signaling, which activated also decreased mediated inflammatory responses by inhibiting delayed induction IFNB1 type I IFN-stimulated genes infected lines reducing activation human by-stander monocytes recruited after K18-hACE2 mice SARS-CoV-2, treatment reduced both early lung viral load disease severity fine-tuning IFN-beta levels. Altogether, these results provide evidence multiple mechanisms underlie anti-inflammatory activities pinpoint potent agent against pathogenic

Language: Английский

Citations

0
Fructose-mediated AGE-RAGE axis: approaches for mild modulation DOI Creative Commons
Halyna Semchyshyn

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 4, 2024

Fructose is a valuable and healthy nutrient when consumed at normal levels (≤50 g/day). However, long-term consumption of excessive fructose elevated endogenous production can have detrimental health impacts. Fructose-initiated nonenzymatic glycation (fructation) considered as one the most likely mechanisms leading to generation reactive species propagation processes. In later stages glycation, poorly degraded advanced products (AGEs) are irreversibly produced accumulated in organism an age- disease-dependent manner. Fructose, along with various products-especially AGEs-are present relatively high concentrations our daily diet. Both exogenous AGEs exhibit wide range biological effects, which be associated following: (1) efficient sources

Language: Английский

Citations

0