Curcumin-Induced Molecular Mechanisms in U-87 MG Glioblastoma Cells: Insights from Global Gene Expression Profiling DOI Creative Commons

Nicole Tendayi Mashozhera,

Chinreddy Subramanyam Reddy,

Yevin Nenuka Ranasinghe

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(10), P. 2108 - 2108

Published: May 9, 2025

Curcumin, a major phytochemical derived from Curcuma longa, has been shown to enhance the efficacy of chemotherapeutic agents such as doxorubicin, 5-fluorouracil, and cisplatin by overcoming drug resistance, making it promising adjunct in treatment glioblastoma. However, global gene-expression changes triggered curcumin glioblastoma remain underexplored. In this study, we investigated effects on human (U87 MG) cells, where significantly reduced cell viability proliferation dose- time-dependent manner induced apoptosis without affecting senescence. Transcriptomic analysis revealed 5036 differentially expressed genes, with pathway enrichment identifying 13 dysregulated cancer-associated pathways. Notably, modulated several key regulators involved MAPK, Ras, TGF-β, Wnt, Cytokine, TNF signaling Several cycle-associated including PRKCG, GDF7, GDF9, GDF15, GDF5, FZD1, FZD2, FZD8, AIFM3, TP53AIP1, CRD14, NIBAN3, BOK, BCL2L10, BCL2L14, BNIPL, FASLG, GZMM, TNFSF10, TNFSF11, TNFSF4, were altered. pro-apoptotic anti-BCL, cell-cycle-regulated genes following treatment, emphasizing its potential role curcumin-mediated anti-tumor effects. This study provides insight into molecular mechanisms underlying curcumin’s action against

Language: Английский

Exploring the Anti-Colon Cancer Potential of Polygonum minus: Integrating In Vitro and In Silico Studies DOI
Zhongming Yang, Zhongguo Yang,

Md Zuki Abu Bakar

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: 64, P. 105853 - 105853

Published: Jan. 6, 2025

Language: Английский

Citations

3
Bioactivity evaluation of Polygonum minus and identification of synergistic phytochemicals with 5-fluorouracil for colon cancer treatment DOI
Zhongming Yang, Zhongguo Yang, Md Zuki Abu Bakar

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: 210, P. 112917 - 112917

Published: Jan. 30, 2025

Language: Английский

Citations

2
Green Approach for the Purification of the Bioactive Compound Saponin from the Root Extract of Argemone mexicana and the Evaluation of Antioxidant, Antimicrobial, Anti-inflammatory and Anticancer Activities DOI

Enayathulla Kathar Basha,

Vijaya Dhamodaran

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

Citations

0
Structural analyses (Spectroscopic and in silico ), DNA-binding and in vitro studies of two popular Sage Species ( Salvia officinalis and Salvia fruticosa ) DOI
Bilge Bıçak, Bahar Gök, Serda Kecel-Gündüz

et al.

Journal of Essential Oil Bearing Plants, Journal Year: 2025, Volume and Issue: 28(1), P. 207 - 223

Published: Jan. 2, 2025

Language: Английский

Citations

0
Transforming breast cancer diagnosis and treatment with large language Models: A comprehensive survey DOI
Mohsen Ghorbian,

Mostaf Ghobaei-Arani,

‪Saeid Ghorbian

et al.

Methods, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Flavonoids from the genus Polygonatum: biological activities and biosynthesis mechanism DOI Creative Commons

Xin-Pei Ye,

Yanyu Hu, Yanxi Chen

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 10, 2025

The genus Polygonatum is a medicinal plant that has been used as food for long time, containing various biologically active compounds, including polysaccharides, saponins, flavonoids, alkaloids, and many others. Polygonatum, like other Chinese herbal plants, can be employed natural medicines, exhibiting reduced incidence of adverse effects compared to synthetic pharmaceuticals. Flavonoids are key biomarkers indicate the quality constitute one primary ingredients. Additionally, flavonoids exhibit range nutritional, biological health-promoting characteristics, antibacterial, antioxidant, anti-inflammatory, antitumor, hypoglycemic properties. This paper reviewed biosynthesis bioactivities from Polygonatum. We hope this would ultimately serve valuable reference development flavonoid-related functional foods

Language: Английский

Citations

0
Curcumin-Induced Molecular Mechanisms in U-87 MG Glioblastoma Cells: Insights from Global Gene Expression Profiling DOI Creative Commons

Nicole Tendayi Mashozhera,

Chinreddy Subramanyam Reddy,

Yevin Nenuka Ranasinghe

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(10), P. 2108 - 2108

Published: May 9, 2025

Curcumin, a major phytochemical derived from Curcuma longa, has been shown to enhance the efficacy of chemotherapeutic agents such as doxorubicin, 5-fluorouracil, and cisplatin by overcoming drug resistance, making it promising adjunct in treatment glioblastoma. However, global gene-expression changes triggered curcumin glioblastoma remain underexplored. In this study, we investigated effects on human (U87 MG) cells, where significantly reduced cell viability proliferation dose- time-dependent manner induced apoptosis without affecting senescence. Transcriptomic analysis revealed 5036 differentially expressed genes, with pathway enrichment identifying 13 dysregulated cancer-associated pathways. Notably, modulated several key regulators involved MAPK, Ras, TGF-β, Wnt, Cytokine, TNF signaling Several cycle-associated including PRKCG, GDF7, GDF9, GDF15, GDF5, FZD1, FZD2, FZD8, AIFM3, TP53AIP1, CRD14, NIBAN3, BOK, BCL2L10, BCL2L14, BNIPL, FASLG, GZMM, TNFSF10, TNFSF11, TNFSF4, were altered. pro-apoptotic anti-BCL, cell-cycle-regulated genes following treatment, emphasizing its potential role curcumin-mediated anti-tumor effects. This study provides insight into molecular mechanisms underlying curcumin’s action against

Language: Английский

Citations

0