The Relationship of Tumor-infiltrating Lymphocyte Ratio with Histopathological Parameters and Effect on Survival in Colorectal Cancers DOI Creative Commons

İsra Oğuz,

Sinan Koca, Süleyman Ersoy

et al.

Turkish Journal of Colorectal Disease, Journal Year: 2024, Volume and Issue: 34(4), P. 134 - 140

Published: Dec. 30, 2024

Introduction: Tumor lymphocyte infiltration demonstrates a positive effect on patient survival in breast cancer, melanoma, renal cell carcinoma, and lung cancer.This study aimed to elucidate the relationship between tumor-infiltrating (TIL) ratio disease-free (DFS) overall (OS) by considering localization, clinical pathological features, microsatellite instability (MSI) status, mutation demographic data.Method: Patients (n=248) diagnosed with colorectal cancer stages 1, 2, 3 were analyzed retrospectively.Patients an Eastern Cooperative Oncology Group performance score of <2 excluded.Clinical characteristics, age, gender, histopathologic TIL ratio, carcinoembryonic antigen (CEA) level patients recorded.Results: Stage, CEA level, N stage, T lymphovascular invasion statistically significant.Early stage (p=0.019),low (p≤0.001),high (p=0.046),low (p=0.004),low (p=0.016),and absence (p=0.037 p=0.046) associated longer DFS.Lymphovascular invasion, levels, using multivariate analysis.According results, hazard (HR) for was 1.68 (95% confidence interval (CI): 1.005-2.807;p=0.048), HR 0.49 CI: 0.293-0.846;p=0.01). Conclusion:Regarding outcomes this research, found be effective indicator DFS, confirmed via analysis present 32% reduction risk recurrence/relapse.The identified as prognostic factor beyond effects grade, MSI status.The current data provides substantial evidence support ratio's consideration staging guidelines.

Language: Английский

CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors DOI Creative Commons
Yi Sun, Elliott J. Yee, Yuki Fujiwara

et al.

Journal for ImmunoTherapy of Cancer, Journal Year: 2025, Volume and Issue: 13(1), P. e010554 - e010554

Published: Jan. 1, 2025

Background Adaptive cellular therapy (ACT), particularly chimeric antigen receptor (CAR)-T cell therapy, has been successful in the treatment of hemopoietic malignancies. However, poor trafficking administered effector T cells to tumor poses a great hurdle for this otherwise powerful therapeutic approach solid cancers. Our previous study revealed that targeting CD93 normalizes vascular functions improve immune checkpoint blockade therapy. The objective is evaluate whether improves ACT Methods Monoclonal antibodies (mAbs) against or IGFBP7 were implanted mouse melanoma models assess effect on ACT. Different sources used, including pre-activated CD8+OT-1, pmel-1 transgenic cells, and CAR-T cells. Rip-OVA Rip-TAG-OVA mice used selective impact T-cell infiltration tumors. For mechanistic studies, maturation was determined by immunofluorescent staining flow cytometry performed examine tumor-infiltrating lymphocytes. Neutralizing mAbs adhesion molecules ICAM1 VCAM1 infused their involvement. Results Blockade pathway increases expression vasculature function. transfer synergistically maturation, as well inhibit progression. Anti-CD93 selectively promotes tumorous setting where upregulated. In model, Conclusions leading improved function advocates application

Language: Английский

Citations

0
Cysteine-rich intestinal protein family: structural overview, functional diversity, and roles in human disease DOI Creative Commons

Xilin Ye,

Qianben Song,

Lumiao Zhang

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 21, 2025

Language: Английский

Citations

0
Elevated expression of ANAPC1 in lung squamous cell carcinoma: clinical implications and mechanisms DOI Creative Commons
Xiaosong Chen,

Feng Chen,

Shu-Jia He

et al.

Future Science OA, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 26, 2025

Aim To investigate the comprehensive expression levels and possible molecular mechanisms of Anaphase Promoting Complex Subunit 1 (ANAPC1) in lung squamous cell carcinoma (LUSC).

Language: Английский

Citations

0
RNA methyltransferase METTL16: from molecular mechanisms to therapeutic prospects in cancers DOI

Zhuozheng Shi,

Xiankui Cao,

Yiming Ma

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217698 - 217698

Published: April 1, 2025

Language: Английский

Citations

0
Regulating tumor cells to awaken T cell antitumor function and enhance melanoma immunotherapy DOI
Weihan Zhang,

Shijun Yuan,

Zipeng Zhang

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123034 - 123034

Published: Dec. 19, 2024

Language: Английский

Citations

3
Microbiome Differences in Colorectal Cancer Patients and Healthy Individuals: Implications for Vaccine Antigen Discovery DOI Creative Commons
Gordon C. Ibeanu, Adekunle Babajide Rowaiye, Joel Okoli

et al.

ImmunoTargets and Therapy, Journal Year: 2024, Volume and Issue: Volume 13, P. 749 - 774

Published: Dec. 1, 2024

Background: Colorectal cancer (CRC) is the third most prevalent worldwide, with numerous risk factors contributing to its development.Recent research has illuminated significant role of gut microbiota in CRC pathogenesis, identifying various microbial antigens as potential targets for vaccine development.Aim: This review aimed at exploring sources that could be harnessed create effective vaccines and understand microbiome-CRC interactions carcinogenesis.Methods: A comprehensive search original articles on pathological links between key candidates, particularly those more tissues, was conducted.This involved extensive use PubMed Medline databases, well Google Scholar engine, utilizing pertinent keywords.A total one hundred fortythree relevant English, mostly published 2018 2024, were selected.Results: Numerous microbes, bacteria viruses, are significantly overrepresented tissues have been shown promote tumorigenesis by inducing inflammation modulating immune system.This makes them promising candidates development vaccines. Conclusion:The selection focuses their capacity trigger a strong response link tumor presence progression.Identifying validating these through preclinical testing essential developing vaccine.Plain Language Summary: common serious disease affects many people worldwide.Research other microorganisms our play CRC.This identify specific used develop against CRC.The researchers searched scientific found certain viruses commonly growth causing affecting system.These microbes vaccines.The identification crucial step towards can prevent or treat CRC.Further needed validate findings move closer creating an this disease.In simpler terms, how microbiome contributes colorectal searching help disease.

Language: Английский

Citations

2
New Relevant Evidence in Cholangiocarcinoma Biology and Characterization DOI Open Access

N. M. Porro,

Elena Spínola-Lasso, Mirella Pastore

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(24), P. 4239 - 4239

Published: Dec. 19, 2024

Among solid tumors, cholangiocarcinoma (CCA) emerges as one of the most difficult to eradicate. The silent and asymptomatic nature this tumor, particularly in its early stages, well high heterogeneity at genomic, epigenetic, molecular levels delay diagnosis, significantly compromising efficacy current therapeutic options thus contributing a dismal prognosis. Extensive research has been conducted on pathobiology CCA, recent advances have made classification characterization new targets. Both targeted therapy immunotherapy emerged effective safe strategies for various types cancers, demonstrating potential benefits advanced CCA. Furthermore, deeper comprehension cellular components tumor microenvironment (TME) opened up possibilities innovative treatment methods. This review discusses evidence biology highlighting novel possible druggable

Language: Английский

Citations

0
The Relationship of Tumor-infiltrating Lymphocyte Ratio with Histopathological Parameters and Effect on Survival in Colorectal Cancers DOI Creative Commons

İsra Oğuz,

Sinan Koca, Süleyman Ersoy

et al.

Turkish Journal of Colorectal Disease, Journal Year: 2024, Volume and Issue: 34(4), P. 134 - 140

Published: Dec. 30, 2024

Introduction: Tumor lymphocyte infiltration demonstrates a positive effect on patient survival in breast cancer, melanoma, renal cell carcinoma, and lung cancer.This study aimed to elucidate the relationship between tumor-infiltrating (TIL) ratio disease-free (DFS) overall (OS) by considering localization, clinical pathological features, microsatellite instability (MSI) status, mutation demographic data.Method: Patients (n=248) diagnosed with colorectal cancer stages 1, 2, 3 were analyzed retrospectively.Patients an Eastern Cooperative Oncology Group performance score of <2 excluded.Clinical characteristics, age, gender, histopathologic TIL ratio, carcinoembryonic antigen (CEA) level patients recorded.Results: Stage, CEA level, N stage, T lymphovascular invasion statistically significant.Early stage (p=0.019),low (p≤0.001),high (p=0.046),low (p=0.004),low (p=0.016),and absence (p=0.037 p=0.046) associated longer DFS.Lymphovascular invasion, levels, using multivariate analysis.According results, hazard (HR) for was 1.68 (95% confidence interval (CI): 1.005-2.807;p=0.048), HR 0.49 CI: 0.293-0.846;p=0.01). Conclusion:Regarding outcomes this research, found be effective indicator DFS, confirmed via analysis present 32% reduction risk recurrence/relapse.The identified as prognostic factor beyond effects grade, MSI status.The current data provides substantial evidence support ratio's consideration staging guidelines.

Language: Английский

Citations

0