Ablation of Mitophagy Receptor FUNDC1 Accentuates Septic Cardiomyopathy through ACSL4-Dependent Regulation of Ferroptosis and Mitochondrial Integrity

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 225, P. 75 - 86

Published: Sept. 24, 2024

Language: Английский

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Acute Kidney Injury During Sepsis and Prognostic Role of Coexistent Chronic Heart Failure

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 964 - 964

Published: Feb. 3, 2025

Background: The recently updated definition of sepsis considers pathophysiologic mechanisms to guide initial therapy. Clearly, generalized recommendations for therapy may be limited by pre-existing multimorbidity in addition sepsis-related multi-organ failure. In particular, a recommendation regarding fluid rescue require adequate cardiac function and/or the absence sepsis-induced cardiomyopathy. all patients with compromised or cardiomyopathy, patient-specific regimen is required prevent pulmonary edema and early death. Similarly, sepsis, acute kidney injury without chronic disease requires attention paid excretory renal avoid hypervolemia-mediated heart addition, hyponatremia related intravascular hypovolemia explained vasopressin stimulation. However, hypothetically, hyporesponsiveness contribute injury. this review, relevant cardiorenal pathomechanisms will assessed context Conclusions: conclusion, has take comorbidity, if present, into account. extent which aggravates sepsis-mediated insufficiency should remain subject further study.

Language: Английский

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Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 6, 2025

Sepsis, a heterogeneous illness produced by dysregulated host response to infection, remains severe mortality risk. Recent discoveries in sepsis research have stressed phenotyping as feasible strategy for tackling heterogeneity and enhancing therapy precision. Sepsis has moved from traditional stratifications based on severity prognosis dynamic, phenotype-driven therapeutic options. This review covers recent progress connecting subgroups personalized treatments, with focus phenotype-based predictions decision-support systems. Despite ongoing challenges, such standardizing frameworks incorporating findings into clinical practice, this topic enormous promise. By investigating phenotypic variation responses, we hope uncover new biomarkers solutions, laying the groundwork more effective therapies and, ultimately improving patient outcomes.

Language: Английский

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Pericyte-derived extracellular vesicles improve vascular barrier function in sepsis via the Angpt1/PI3K/AKT pathway and pericyte recruitment: an in vivo and in vitro study

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 12, 2025

Extracellular vesicles derived from pericytes (PCEVs) have been shown to improve vascular permeability, with their therapeutic effects attributed the presence of pro-regenerative molecules. We hypothesized that angiopoietin 1 (Angpt1) carried by PCEVs contributes after sepsis. A cecal ligation and puncture (CLP)-induced sepsis rat model was used in vivo, on endothelial cells were studied vitro. First, proteomic Gene Ontology enrichment analyses performed analyze mechanism PCEVs, revealing angiogenesis-related protein Angpt1 highly expressed PCEVs. then down-regulated The role PCEV-carried intestinal barrier function, PCs recruitment, inflammatory cytokines measured using septic Sprague–Dawley rats platelet-derived growth factor receptor beta (PDGFR-β)-Cre + mT/mG transgenic mice. significantly improved proliferation, angiogenesis CLP-induced gut injury both vivo Further studies exert a protective effect function PC recruitment. Additionally, reduced serum levels. Our data also demonstrated levels phospho-PI3K phospho-Akt increased administration, whereas knocking out suppressed through decreased activation PI3K/Akt signaling. protect against regulating barrier, promoting protecting restoring properties via Angpt1/PI3K/AKT pathway.

Language: Английский

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Value of blood perfusion index in guiding fluid resuscitation against septic shock

Clinical Hemorheology and Microcirculation, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Objective Septic shock is a serious medical condition characterized by extreme inflammation and blood vessel permeability. Fluid resuscitation crucial treatment for septic shock, but the optimal approach fluid management remains controversial. In this study, we explored how perfusion index (PI) monitoring can help direct therapy shock. Methods Between January 2019 December 2021, 50 patients with were admitted to The Affiliated Hospital of Hangzhou Normal University randomly assigned either control or study group (25 cases each). All given sepsis bundle recommended 2018 guidelines subjected Pulse Indicator Continuous Cardiac Output (PiCCO) -based hemodynamic monitoring. was administered based on specific indicators in group. We used PI research Several parameters assessed, including lactate (BLAC), hemoglobin (Hb), stroke volume (SVI), norepinephrine dosage, extravascular lung water (EVLW), ICU mortality. Results There statistically significant reductions BLAC compared 6 h, 24 48 h after (P < 0.05). group, SVI higher post-treatment Norepinephrine doses similarly lowered comparison between two groups, less than that resuscitation, difference significant. mortality [44%vs. 56% (X 2 = 0.720, P 0.572)] lower those had no statistical significance. Conclusions guided improves while decreasing avoid risk overload due increased EVLW overload, demonstrating clinical significance application value.

Language: Английский

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The relationship between admission Braden score and poor prognosis in Sepsis patients: evidence from the MIMIC-III database

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 15, 2025

Language: Английский

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Association of mean corpuscular volume with 28-day mortality in sepsis patients: A retrospective cohort study using eICU data

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0321213 - e0321213

Published: April 21, 2025

Introduction The issue of mortality due to sepsis remains a significant concern in the field medicine. Previous researches have demonstrated an association between mean corpuscular volume (MCV) and from range diseases. objective this study was investigate relationship MCV risk large multicentre cohort. Method A retrospective cohort conducted using data eICU Collaborative Research Database 2014–2015. determined within initial 24 hours ICU admission, with patients subsequently classified into quartiles based on their levels. Multivariate regression models were employed correlation 28-day mortality, adjustments made for potential confounding factors such as age, sex, body mass index, vital signs comorbidities. To evaluate dose-response sepsis, smoothed curve fitting threshold effects analysis utilised. Results total 9,415 included rate 9.38% (883/9415). After adjusting variables, it found that odds ratio (OR) 1.11 (95% CI 1.01, 1.23, P=0.04) increased followed by each 1 fl increase MCV. fitted curves nonlinear positive mortality. inflection point level 83 fl. At <83 fl, there (OR 1.10, 95% 1.02, 1.17, P =0.004). Conclusions There is non-linear death sepsis. Clinicians should be aware changes indicator, especially high

Language: Английский

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Pyroptosis in sepsis-associated acute kidney injury: mechanisms and therapeutic perspectives

Critical Care, Journal Year: 2025, Volume and Issue: 29(1)

Published: April 23, 2025

Language: Английский

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Decoding TMAO in the Gut-Organ Axis: From Biomarkers and Cell Death Mechanisms to Therapeutic Horizons

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 3363 - 3393

Published: April 1, 2025

The gut microbiota and its metabolites are bi-directionally associated with various human illnesses, which has received extensive attention. Trimethylamine N-oxide (TMAO) is a metabolite produced in the liver, may serve role of an "axis" connecting host organs. TMAO levels significantly higher blood individuals cardiovascular, renal, neurological, metabolic diseases. Endothelial cells crucial for regulating microcirculation maintaining tissue organ barriers widely recognized as target TMAO. not only induces endothelial dysfunction but also acts on cell types, such cells, epithelial vascular smooth muscle nerve pancreatic triggering multiple death mechanisms, including necrosis programmed death, thereby influencing health. This paper thoroughly covers origins, production, pathways TMAO, emphasizing importance early detection prognosis diseases "Gut-Organ" axis, well mechanisms influence diseases, particularly cross-talk death. Furthermore, we cover recent advances treating by structure enzyme activity to metabolism reduce levels, use probiotics, prebiotics, antibiotics, anti-inflammatory drugs, antiplatelet hypoglycemic lipid-lowering natural products.

Language: Английский

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Influencing factor analysis and clinical efficacy of early intervention in severe acute pancreatitis with persistent organ failure

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 9, 2025

Language: Английский

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