Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: June 1, 2025
Abstract
Tuning
the
functional
properties
of
nanocarriers
has
gained
increasing
interest
in
recent
years
as
a
key
strategy
to
accelerate
clinical
translation
nanomedicine.
Once
come
into
contact
with
biological
fluid
such
blood,
interactions
occur
at
nanocarrier/biological
interface
that
alter
identity
nanocarriers.
As
knowledge
this
field
is
rapidly
evolving,
review
highlights
some
latest
developments
(2021
early
2025)
and
covers
significant
findings
nano‐biointerface.
Specifically,
current
obstacles
achieving
goal
targeting
are
addressed
emphasis
on
formation
impact
adsorbed
proteins,
so‐called
protein
corona.
The
strategies
overcome
these
explored
by
rational
design
using
biomimetic
coatings
(proteins
membranes)
enhance
favorable
between
systems.
challenges
problems
related
gold
standard
(poly(ethylene
glycol)ylation),
availability
for
proteins
(functionalization,
structural
integrity),
etc.,
alternatives
discussed.
Finally,
future
perspectives
discussed
facilitate
Cancer Cell International,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 27, 2025
Theranostics
is
a
way
of
treating
illness
that
blends
medicine
with
testing.
Specific
characteristics
should
be
present
in
the
best
theranostic
agents
for
cancer:
(1)
drugs
safe
and
non-toxic;
(2)
they
able
to
treat
cancer
selectively;
(3)
build
up
only
cancerous
tissue.
Liposomes
(LPs)
are
one
most
efficient
drug
delivery
methods
based
on
nanotechnology.
Stealth
LPs
commercial
have
recently
had
an
impact
treatment.
Using
valuable
information
from
each
imaging
technique,
along
multimodality
functionality
liposomal
therapeutic
agents,
makes
them
very
appealing
personalized
monitoring
how
well
working
against
vivo
predicting
therapies
will
work.
On
other
hand,
their
use
as
nanoparticle
systems
currently
research
development
phase.
Nanoscale
system
innovation
has
made
LP-nanoparticle
hybrid
structures
useful
combining
methods.
LP-hybrid
nanoparticles
better
at
killing
cells
than
LP
counterparts,
making
excellent
options
vitro
applications.
Hybrid
liposomes
(HLs)
could
used
future
carriers
find
targets.
This
would
combine
features
synthetic
biological
systems.
Overarchingly,
this
article
provided
comprehensive
overview
many
types
detection,
therapy,
analysis.
An
evaluation
pros
cons
HLs
detection
treatment
also
been
conducted.
The
study
included
recent
significant
We
conclude
by
outlining
potential
benefits
drawbacks
approach
concurrent
different
malignancies,
its
prospects.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(6), P. 940 - 940
Published: March 10, 2025
Exosomes
have
emerged
as
pivotal
players
in
precision
oncology,
offering
innovative
solutions
to
longstanding
challenges
such
metastasis,
therapeutic
resistance,
and
immune
evasion.
These
nanoscale
extracellular
vesicles
facilitate
intercellular
communication
by
transferring
bioactive
molecules
that
mirror
the
biological
state
of
their
parent
cells,
positioning
them
transformative
tools
for
cancer
diagnostics
therapeutics.
Recent
advancements
exosome
engineering,
artificial
intelligence
(AI)-driven
analytics,
isolation
technologies
are
breaking
barriers
scalability,
reproducibility,
clinical
application.
Bioengineered
exosomes
being
leveraged
CRISPR-Cas9
delivery,
while
AI
models
enhancing
biomarker
discovery
liquid
biopsy
accuracy.
Despite
these
advancements,
key
obstacles
heterogeneity
populations
lack
standardized
protocols
persist.
This
review
synthesizes
pioneering
research
on
biology,
molecular
translation,
emphasizing
dual
roles
both
mediators
tumor
progression
intervention.
It
also
explores
emerging
areas,
including
microbiome–exosome
interactions
integration
machine
learning
exosome-based
medicine.
By
bridging
innovation
with
translational
strategies,
this
work
charts
a
forward-looking
path
integrating
into
next-generation
care,
setting
it
apart
comprehensive
guide
overcoming
technological
hurdles
rapidly
evolving
field.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3915 - 3915
Published: April 21, 2025
Neurological
diseases,
including
neurodegenerative
disorders
and
stroke,
represent
significant
medical
challenges
due
to
their
complexity
the
limitations
of
current
treatment
approaches.
This
review
explores
potential
stem
cell
(SC)-derived
exosomes
(Exos)
as
a
transformative
therapeutic
strategy
for
these
diseases.
Exos,
especially
those
derived
from
SCs,
exhibit
natural
targeting
ability,
biocompatibility,
capacity
cross
blood-brain
barrier
(BBB),
making
them
ideal
vehicles
drug
delivery.
provides
an
in-depth
discussion
properties
advantages
SC-Exos.
It
highlights
synergistic
benefits
in
approaches
treat
neurological
article
discusses
mechanisms
action
SC-Exos,
highlighting
ability
target
specific
cells,
modulate
disease
pathways,
provide
controlled
release
agents.
Applications
have
been
investigated,
demonstrating
improve
outcomes
conditions
such
Alzheimer's
Disease
(AD),
Parkinson's
(PD),
stroke.
Moreover,
Exos-coated
nanoparticles
(NPs)
combine
Exos
with
multifunctionality
NPs.
integration
takes
advantage
exosome
membrane
biocompatibility
capabilities
while
preserving
NPs'
beneficial
features,
loading
release.
As
result,
NPs
may
enhance
precision,
efficacy,
safety
interventions.
In
conclusion,
SC-Exos
promising
innovative
approach
treating
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 8, 2025
The
critical
role
of
the
immune
system
in
brain
function
and
dysfunction
is
well
recognized,
yet
development
therapies
for
psychiatric
diseases
has
been
slow
due
to
concerns
about
iatrogenic
deficiencies.
These
are
emphasized
by
lack
objective
diagnostic
tools
psychiatry.
A
promise
resolve
this
conundrum
lies
exploitation
extracellular
vesicles
(EVs)
that
physiologically
produced
or
can
be
synthetized.
EVs
regulate
recipient
cell
functions
offer
potential
EVs-based
therapies.
Intranasal
administration
enables
targeting
specific
regions
functions,
thereby
facilitating
design
precise
treatments
diseases.
such
requires
navigating
four
dynamically
interacting
networks:
neuronal,
glial,
immune,
EVs.
networks
profoundly
influenced
fluid
distribution.
They
crucial
homeostasis,
cellular
intercellular
communication.
Fluid
abnormalities,
like
edema
altered
cerebrospinal
(CSF)
dynamics,
disrupt
these
networks,
negatively
impacting
health.
deeper
understanding
above-mentioned
vital
creating
biomarker
panels
identify
distinct
patient
subsets
with
similar
neuro-behavioral
symptoms.
Testing
functional
pathways
biomarkers
could
lead
new
therapeutic
tools.
Regulatory
approval
will
depend
on
robust
preclinical
data
reflecting
progress
interdisciplinary
areas,
which
pave
way
innovative
treatments.
Highly
collaborative
teams
needed
achieve
ambitious
goals.
