The future of rodent models in depression research

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(11), P. 686 - 701

Published: Oct. 2, 2019

Language: Английский

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Ketamine as an antidepressant: overview of its mechanisms of action and potential predictive biomarkers

Therapeutic Advances in Psychopharmacology, Journal Year: 2020, Volume and Issue: 10

Published: Jan. 1, 2020

Ketamine, a drug introduced in the 1960s as an anesthetic agent and still used for that purpose, has garnered marked interest over past two decades emerging treatment major depressive disorder. With increasing evidence of its efficacy treatment-resistant depression potential anti-suicidal action, great deal investigation been conducted on elucidating ketamine’s effects brain. Of particular therapeutic is ability ketamine to exert rapid antidepressant properties early several hours after administration. This stark contrast delayed observed with traditional antidepressants, often requiring weeks therapy clinical response. Furthermore, appears have unique mechanism action involving glutamate modulation via actions at N-methyl-D-aspartate (NMDA) [Formula: see text]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, well downstream activation brain-derived neurotrophic factor (BDNF) mechanistic target rapamycin (mTOR) signaling pathways potentiate synaptic plasticity. paper provides brief overview regard pharmacology/pharmacokinetics, toxicology, current state trials depression, postulated mechanisms biomarkers (biochemical, inflammatory, metabolic, neuroimaging sleep-related cognitive) predicting response and/or monitoring outcome ketamine.

Language: Английский

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The chronotherapeutic treatment of bipolar disorders: A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology

Bipolar Disorders, Journal Year: 2019, Volume and Issue: 21(8), P. 741 - 773

Published: Oct. 14, 2019

Abstract Aims To systematically review the literature on efficacy and tolerability of major chronotherapeutic treatments bipolar disorders (BD)—bright light therapy (LT), dark (DT), utilizing sleep deprivation (SD), melatonergic agonists (MA), interpersonal social rhythm (IPSRT), cognitive behavioral adapted for BD (CBTI‐BP)—and propose treatment recommendations based a synthesis evidence. Methods PRISMA‐based systematic literature. Results The acute antidepressant (AD) LT was supported by several open‐label studies, three randomized controlled trials (RCTs), one pseudorandomized trial. SD showed rapid, AD response rates 43.9%, 59.3%, 59.4% in eight case series, 11 uncontrolled, RCT, respectively. Adjunctive DT obtained significant, rapid anti‐manic results RCT study. seven studies MA yielded very limited data activity, conflicting evidence both antimanic maintenance efficacy, support from two series improved euthymic states. IPSRT monotherapy II depression had 41%, 67%, 67.4% open respectively; as adjunctive reducing relapse RCTs. Among subjects with insomnia, single found CBTI‐BP effective delaying manic improving sleep. Chronotherapies were generally safe well‐tolerated. Conclusions outcome use BP is variable, bases that differ size, study quality, level evidence, non‐standardized protocols. Evidence‐informed practice are offered.

Language: Английский

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The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression

Molecular Biology Reports, Journal Year: 2019, Volume and Issue: 47(1), P. 753 - 770

Published: Oct. 14, 2019

Language: Английский

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Effect of Intraoperative Esketamine Infusion on Postoperative Sleep Disturbance After Gynecological Laparoscopy

JAMA Network Open, Journal Year: 2022, Volume and Issue: 5(12), P. e2244514 - e2244514

Published: Dec. 1, 2022

Importance Postoperative sleep disturbance (PSD) is common in patients after surgery. Objective To examine the effect of intraoperative esketamine infusion on incidence PSD who underwent gynecological laparoscopic Design, Setting, and Participants This single-center, double-blind, placebo-controlled randomized clinical trial was conducted from August 2021 to April 2022 First Affiliated Hospital Zhengzhou University China. included aged 18 65 years with an American Society Anesthesiologist Physical Status classification I III (with indicating a healthy patient, II patient mild systemic disease, severe disease) Patients were randomly assigned either group or control group. Data analyzed using per protocol principle. Interventions received continuous esketamine, 0.3 mg/kg/h, intraoperatively. equivalent volume saline. Main Outcomes Measures The primary outcome postoperative days (PODs) 1 3. defined as numeric rating scale score 6 higher Athens Insomnia Scale points higher. secondary outcomes anxiety depression scores Anxiety Depression Scale, pain visual analog scale, hydromorphone consumption, risk factors associated PSD. Results A total 183 female (n = 91; median [IQR] age, 45 [35-49] years) 92; 43 [32-49] years). significantly lower than POD (22.8% vs 44.0%; odds ratio [OR], 0.38 [95% CI, 0.20-0.72]; P .002) 3 (7.6% 19.8%; OR, 0.33 0.13-0.84]; .02). There no differences between 2 groups. consumption first 24 hours (3.0 [range, 2.8-3.3] mg 3.2 2.9-3.4] mg; .04) movement (3 [3-4] 4 [3-5] points; < .001) On multivariable logistic regression, preoperative (OR, 1.31; 95% 1.01-1.70) 1.67; 1.04-1.80) scores, duration anesthesia 1.04; 1.00-1.08), 1.92; 1.24-2.96) identified Conclusions Relevance this showed prophylactic Further studies are needed confirm these results. Trial Registration Chinese Clinical Registry Identifier: ChiCTR2100048587

Language: Английский

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Regulation of the microglial polarization for alleviating neuroinflammation in the pathogenesis and therapeutics of major depressive disorder

Life Sciences, Journal Year: 2025, Volume and Issue: 362, P. 123373 - 123373

Published: Jan. 4, 2025

Language: Английский

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The role of adenosine receptors in mood and anxiety disorders

Journal of Neurochemistry, Journal Year: 2019, Volume and Issue: 151(1), P. 11 - 27

Published: July 30, 2019

Adenosine receptor subtypes, first described 40 years ago, are known to regulate diverse biological functions and have a role in various conditions, such as cerebral cardiac ischemia, immune inflammatory disorders cancer. In the brain, they limit potentially dangerous over excitation, but also mechanisms essential sleep psychiatric disorders. this review, we discuss of adenosine receptors mood anxiety Activation A2A is associated with increased depression-like symptoms, while A1 signaling elicits rapid antidepressant effects. Indeed, several lines evidence demonstrate that therapeutic effects different non-pharmacological treatments depression, like deprivation electroconvulsive therapy mediated by up-regulation or activation. addition, may play transcranial direct current stimulation deep brain stimulation. As potential downstream mechanism, which facilitates receptors, propose crosstalk between adenosinergic glutamatergic systems via synaptic plasticity protein Homer1a α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Moreover, involved control circadian rhythms, homeostasis some neuro-immunological mechanisms, all them implicated regulation. Antagonists caffeine general anxiogenic particular, appear an important pathophysiology Taken together, results discussed here indicate system both etiology treatment

Language: Английский

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Perspectives in affective disorders: Clocks and sleep

European Journal of Neuroscience, Journal Year: 2019, Volume and Issue: 51(1), P. 346 - 365

Published: Jan. 31, 2019

Abstract Mood disorders are often characterised by alterations in circadian rhythms, sleep disturbances and seasonal exacerbation. Conversely, chronobiological treatments utilise zeitgebers for rhythms such as light to improve mood stabilise sleep, manipulations of timing duration rapid antidepressant modalities. Although deprivation (“wake therapy”) can act within hours, its mood‐elevating effects be maintained regular morning administration/medication/earlier it has not entered the guidelines treating affective a first‐line treatment. The hindrances using chronotherapeutics may lie their lack patentability, few sponsors carry out large multi‐centre trials, non‐reimbursement medical insurance perceived difficulty or exotic “alternative” nature. Future use promoted new technology (single‐sample phase measurements, phone apps, movement trackers) that provides ambulatory documentation over long periods feedback therapist patient. Light combinations with cognitive behavioural therapy hygiene practice speed up also maintain response. urgent need antidepressants should hopefully lead reconsideration implementation these non‐pharmacological methods, well further clinical trials. We review putative neurochemical mechanisms underlying effect therapy, current knowledge linking clocks disorders: neurotransmitter switching, stress cortico‐limbic reactivity, clock genes, cortical neuroplasticity, connectomics neuroinflammation. Despite complexity multi‐system mechanisms, more insight will fine tuning better application sleep‐related depression.

Language: Английский

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Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi‐disciplinary literature review and agenda for future research from the ISBD task force on chronobiology

Bipolar Disorders, Journal Year: 2021, Volume and Issue: 24(3), P. 232 - 263

Published: Dec. 1, 2021

Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep, and appetite. Since many these processes are regulated by circadian function, rhythm disturbance has been examined as a biological feature underlying BD. The International Society for Bipolar Disorders Chronobiology Task Force (CTF) was commissioned to review evidence neurobiological behavioral mechanisms pertinent BD.Drawing upon expertise animal models, biomarkers, physiology, behavior, CTF analyzed the relevant cross-disciplinary literature precisely frame discussion around disruption BD, highlight key findings, first time integrate findings across levels analysis develop an internally consistent, coherent theoretical framework.Evidence from multiple sources implicates system mood regulation, with corresponding associations BD diagnoses mood-related traits reported genetic, cellular, physiological, domains. However, does not appear be specific is present variety high-risk, prodromal, syndromic psychiatric disorders. Substantial variability ambiguity among definitions, concepts assumptions research have limited replication emergence consensus findings.Future rhythms its role warranted. Well-powered studies that carefully define between BD-related chronobiologically-related constructs, will most illuminating.

Language: Английский

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A retrospective analysis of ketamine intravenous therapy for depression in real-world care settings

Journal of Affective Disorders, Journal Year: 2022, Volume and Issue: 301, P. 486 - 495

Published: Jan. 11, 2022

Outcomes of ketamine intravenous therapy (KIT) for depression in real-world care settings have been minimally evaluated. We set out to quantify treatment response KIT a large sample patients from community-based practices. retrospectively analyzed 9016 who received between 2016 and 2020 at one 178 community practices across the United States. Depression symptoms were evaluated using Patient Health Questionnaire-9 (PHQ-9). The induction phase was defined be series 4–8 infusions administered over 7 28 days. Among 537 underwent had sufficient data, 53.6% showed (≥ 50% reduction PHQ-9 score) 14–31 days post-induction 28.9% remitted (PHQ-9 score drop < 5). effect size d = 1.5. with baseline suicidal ideation (SI), 73.0% exhibited SI. A subset (8.4%) experienced an increase depressive after while 6.0% reported increased rate uniform 4 levels severity. However, more severe illness weakly correlated greater scores remission status inversely Kaplan-Meier analyses that patient responds has approximately 80% probability sustaining weeks 60% 8 weeks, even without maintenance infusions. can elicit robust antidepressant clinics; however, small percentage worsened.

Language: Английский

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