Psychiatry and Clinical Neurosciences, Journal Year: 2023, Volume and Issue: 78(1), P. 41 - 50
Published: Oct. 2, 2023
Childhood maltreatment (CM) is an important risk factor for major depressive disorder (MDD). This study aimed to explore the specific effect of CM on cerebral blood flow (CBF) and brain functional connectivity (FC) in MDD patients.
Language: Английский
Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(9), P. 1603 - 1612
Published: Aug. 21, 2023
Abstract Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, long-term effects of adversity on structure association individual neurobiological heterogeneity with behavior have yet be elucidated. Here we estimated normative models structural development based a lifespan profile longitudinal at-risk cohort aged 25 years ( n = 169). This revealed widespread morphometric changes brain, partially adversity-specific features. pattern was replicated at age 33 114) independent sample 22 115). At level, greater volume contractions relative model were predictive future anxiety. We show stable signature that persists into adulthood emphasize importance considering individual-level rather than group-level predictions explain emerging psychopathology.
Language: Английский
Citations
36
Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(4), P. 287 - 299
Published: Feb. 3, 2024
BackgroundChronic childhood stress is a prominent risk factor for developing affective disorders, yet mechanisms underlying this association remain unclear. Maintenance of optimal serotonin (5-HT) levels during early postnatal development critical the maturation brain circuits. Understanding long-lasting effects life (ELS) on serotonin-modulated connectivity crucial to develop treatments arising from stress.MethodsUsing mouse model chronic developmental stress, we determined consequences ELS 5-HT circuits and behavior in female male mice. Using FosTRAP mice, cross-correlated regional c-fos density determine brain-wide functional raphe nucleus. We next performed vivo fiber photometry establish ELS-induced deficits dynamics optogenetics stimulate release improve behavior.ResultsAdult mice exposed showed heightened anxiety-like behavior. further enhanced susceptibility acute by disrupting nucleus activity neuron population, conjunction with increased orbitofrontal cortex (OFC) disrupted medial OFC (mOFC). Optogenetic stimulation terminals mOFC elicited an anxiolytic effect sex-dependent manner.ConclusionThese findings suggest significant disruption 5-HT-modulated response ELS, implications vulnerability. The raphe-mOFC circuit provides potential targeted stimulation-based disorders that arise adversities.
Language: Английский
Citations
14
Addiction Biology, Journal Year: 2024, Volume and Issue: 29(7)
Published: July 1, 2024
Abstract Substance use disorders (SUDs) are seen as a continuum ranging from goal‐directed and hedonic drug to loss of control over intake with aversive consequences for mental physical health social functioning. The main goals our interdisciplinary German collaborative research centre on Losing Regaining Control Drug Intake (ReCoDe) (i) study triggers (drug cues, stressors, priming) modifying factors (age, gender, activity, cognitive functions, childhood adversity, factors, such loneliness contact/interaction) that longitudinally modulate the trajectories losing regaining consumption under real‐life conditions. (ii) To underlying behavioural, neurobiological mechanisms disease drug‐related behaviours (iii) provide non‐invasive mechanism‐based interventions. These achieved by: (A) using innovative mHealth (mobile health) tools monitor effects patterns in real life cohort 900 patients alcohol disorder. This approach will be complemented by animal models addiction 24/7 automated behavioural monitoring across an entire trajectory; i.e. naïve state drug‐taking or resilience‐like state. (B) identification and, if applicable, computational modelling key molecular, psychological (e.g., reduced flexibility) mediating trajectories. (C) Developing testing interventions Just‐In‐Time‐Adaptive‐Interventions (JITAIs), various brain stimulations (NIBS), individualized activity) specifically target intake. Here, we report most important results first funding period outline future strategy.
Language: Английский
Citations
13
Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(10), P. 3245 - 3267
Published: April 24, 2024
Environmental experiences play a critical role in shaping the structure and function of brain. Its plasticity response to different external stimuli has been focus research efforts for decades. In this review, we explore effects adversity on brain's its implications brain development, adaptation, emergence mental health disorders. We are focusing adverse events that emerge from immediate surroundings an individual, i.e., microenvironment. They include childhood maltreatment, peer victimisation, social isolation, affective loss, domestic conflict, poverty. also take into consideration exposure environmental toxins. Converging evidence suggests types may share common underlying mechanisms while exhibiting unique pathways. However, they often studied limiting our understanding their combined interconnected nature impact. The integration large, deep-phenotyping datasets collaborative can provide sufficient power analyse high dimensional profiles advance systematic mapping neuronal mechanisms. This review provides background future research, highlighting importance cumulative impact various adversities, through data-driven approaches integrative multimodal analysis techniques.
Language: Английский
Citations
12
Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 162, P. 105699 - 105699
Published: May 6, 2024
Robust epidemiological evidence of risk and protective factors for psychosis is essential to inform preventive interventions. Previous syntheses have classified these according their strength association with psychosis. In this critical review we appraise the distinct overlapping mechanisms 25 key environmental psychosis, link mechanistic pathways that may contribute neurochemical alterations hypothesised underlie psychotic symptoms. We then discuss implications our findings future research, specifically considering interactions between factors, exploring universal subgroup-specific improving understanding temporality dynamics, standardising operationalisation measurement developing interventions targeting factors.
Language: Английский
Citations
9
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 126, P. 110783 - 110783
Published: May 4, 2023
Language: Английский
Citations
22
Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(12), P. 948 - 958
Published: April 16, 2024
Early adverse experiences are assumed to affect fundamental processes of reward learning and decision making. However, computational neuroimaging studies investigating these circuits in the context adversity sparse limited conducted adolescent samples, leaving long-term effects unexplored.
Language: Английский
Citations
5
Annual Review of Developmental Psychology, Journal Year: 2023, Volume and Issue: 5(1), P. 285 - 307
Published: Aug. 24, 2023
Adolescence is a period of life that encompasses biological maturation and profound change in social roles. It also associated with the onset mental health problems. The field developmental cognitive neuroscience has advanced our understanding development brain within its immediate cultural context. In time rising rates problems among adolescents across globe, it important to understand how wider societal, structural, contexts young people are impacting their social-cognitive maturation. this article, we review landscape youth during adolescence consider potential role research effects current determinants adolescent health, including socioeconomic inequality, city living, eco-anxiety about climate crisis.
Language: Английский
Citations
12
The Journal of Physiology, Journal Year: 2024, Volume and Issue: 602(9), P. 2047 - 2060
Published: March 18, 2024
Abstract Adverse experiences in early life can induce maladaptive responses to acute stress later life. Chronic social isolation during adolescence is an adversity that precipitate stress‐related psychiatric disorders. We found male mice after 8 weeks of adolescent (SI) have markedly increased aggression being exposed 2 h restraint (RS), which was accompanied by a significant increase AMPA receptor‐ and NMDA receptor‐mediated synaptic transmission prefrontal cortex (PFC) pyramidal neurons SI RS males. Compared group‐housed counterparts, males exhibited significantly decreased level histone H3 acetylation PFC. Systemic administration class I deacetylase inhibitors, romidepsin or MS‐275, ameliorated the aggressive behaviour, as well general interaction deficits, Electrophysiological recordings also normalization PFC glutamatergic currents treatment mice. These results revealed epigenetic mechanism intervention avenue for induced chronic isolation. image Key points Adolescent A socially isolated (SI ). Treatment with (HDAC) inhibitors ameliorates behaviour deficits males, normalizes neurons. It provides aberrant
Language: Английский
Citations
4
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Sept. 10, 2024
Numerous preclinical and clinical studies have shown that stress is one of the main environmental factor playing a significant role in pathogeny life-course bowel diseases. However, stressful events occur early life, even during fetal leave different traces within central nervous system, area involved response autonomic network but also emotion, cognition memory regulation. Early-life can disrupt prefrontal-amygdala circuit thus favoring an imbalance system hypothalamic-pituitary adrenal axis, resulting anxiety-like behaviors. The down regulation vagus nerve cholinergic anti-inflammatory pathway favors pro-inflammatory conditions. Recent data suggest emotional abuse at life are aggravating risk factors inflammatory disease. This review aims to unravel mechanisms explain consequences pathophysiology disease their mental co-morbidities. A therapeutic potential will be covered.
Language: Английский
Citations
4