Toxics,
Journal Year:
2024,
Volume and Issue:
12(5), P. 338 - 338
Published: May 6, 2024
More
research
is
needed
to
understand
how
the
maternal
consumption
of
fish
and
fish-borne
toxicants
impacts
infant
neurodevelopment.
The
present
analysis
was
conducted
over
460
mother–infant
pairs
within
ECLIPSES
study.
Dietary
intake
metals
persistent
organic
pollutants
from
(including
white
fish,
blue
seafood)
estimated
in
pregnant
women.
infants
underwent
cognitive,
language,
motor
function
assessments
using
Bayley
Scales
Infant
Development-III
at
40-day
postpartum.
Associations
between
dietary
outcomes
were
assessed
multivariable
linear
regression
models.
Estimated
prenatal
exposure
toxicants,
such
as
arsenic,
inorganic
methylmercury,
dioxin-like
polychlorinated
biphenyls
(DL-PCBs),
non-DL-PCBs,
associated
with
poorer
language
functions
infants,
whereas
no
significant
associations
found
or
cognitive
functions.
Maternal
exceeding
Spanish
recommendation
more
than
71
g
per
day
linked
these
adverse
effects
on
abilities
without
affecting
development.
This
highlights
importance
vigilant
monitoring
environmental
provision
guidance
for
women,
potential
implications
public
health
child
Biological Psychiatry Global Open Science,
Journal Year:
2024,
Volume and Issue:
4(4), P. 100322 - 100322
Published: April 26, 2024
Exposure
to
environmental
pollutants
early
in
life
has
been
associated
with
increased
prevalence
and
severity
of
depression
adolescents;
the
neurobiological
mechanisms
underlying
this
association
are
not
well
understood.
In
current
longitudinal
study,
we
investigated
whether
pollution
burden
adolescence
(9-13
years)
is
altered
brain
activation
connectivity
during
implicit
emotion
regulation
changes
depressive
symptoms
across
adolescence.
145
participants
(N=87
females;
9-13
provided
residential
addresses,
from
which
determined
their
relative
at
census-tract
level,
performed
an
affective
task
scanner.
Participants
also
completed
questionnaires
assessing
three
timepoints,
each
approximately
two
years
apart,
calculated
within-person
slopes
symptoms.
We
conducted
whole-brain
analyses
examine
alterations
function
positively-
negatively-valenced
stimuli,
how
these
effects
related
Greater
was
greater
bilateral
medial
prefrontal
cortex
(MPFC)
stronger
MPFC
regions
within
default
mode
network
(DMN;
e.g.,
temporoparietal
junction,
posterior
cingulate
cortex,
precuneus)
negative
emotions,
increases
those
exposed
higher
burden.
Adolescents
living
communities
characterized
by
showed
DMN
functioning
emotions
that
Environmental Health Perspectives,
Journal Year:
2025,
Volume and Issue:
133(1)
Published: Jan. 1, 2025
Cerebral
palsy
(CP)
is
the
most
common
permanent
neuromotor
disorder
diagnosed
in
childhood.
Although
cases
have
unknown
etiology,
emerging
evidence
suggests
environmental
risk
factors
of
CP.
We
investigated
whether
ambient
toxic
air
contaminants
(TACs)
maternal
residential
area
during
pregnancy,
specifically
volatile
organic
compounds
(VOCs)
and
metals,
were
associated
with
offspring
CP
California.
conducted
a
case-cohort
study
that
included
(N=906)
20%
random
sample
all
live
singleton
births
(N=184,954)
who
lived
within
5-mile
(8-km)
radius
toxics
monitoring
stations
California
2005-2015
as
control
comparison
group.
ascertained
from
diagnostic
records
Department
Developmental
Services.
priori
selected
TACs
suspected
neurotoxicity
developmental
toxicity,
including
14
VOCs
6
metals.
estimated
adjusted
ratio
(RR)
95%
confidence
interval
(CI)
for
average
exposures
to
each
TAC
over
entire
pregnancy
using
modified
Poisson
regression.
For
contaminant
mixtures,
we
used
quantile-based
g-computation
estimate
effects
mixtures
or
Finally,
performed
negative
exposure
analysis
on
estimates
36-48
months
after
delivery
evaluate
uncontrolled
confounding
bias.
Maternal
six
(benzene,
toluene,
1,3-butadiene,
acetone,
acetonitrile,
methylene
chloride)
four
metals
(antimony,
lead,
nickel,
vanadium)
3%-25%
higher
per
interquartile
range
increase,
mixture
(RR=1.24;
CI:
1.08,
1.43)
(RR=1.38;
1.20,
1.58)
stronger.
The
observed
associations
close
null
(36-48
delivery)
In
California,
prenatal
outdoor
air,
largely
attributed
mobile
traffic
emission
sources,
was
an
increased
offspring.
https://doi.org/10.1289/EHP14742.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 6, 2025
Abstract
Objective
Prenatal
phthalate
exposure
is
associated
with
adverse
neurodevelopmental
outcomes,
yet
data
on
impacts
of
early
life
remains
limited.
We
investigated
and
replacement
plasticizer
exposures
from
2
weeks
to
7
years
age
in
relation
brain
anatomical
attributes,
using
serial
structural
magnetic
resonance
imaging
(sMRI).
Material
Methods
Children
were
enrolled
after
birth
into
the
UNC
Baby
Connectome
Project,
a
longitudinal
neuroimaging
study.
Urine
samples
(n=406)
collected
at
each
visit
analyzed
for
17
metabolites.
Among
157
children
contributing
369
sMRIs,
we
calculated
metabolite-specific
average
across
individual’s
urine
used
linear
mixed
models
estimate
associations
log
transformed,
specific
gravity-adjusted
metabolite
concentrations
gray
(GMV)
white
matter
(WMV),
cortical
volume
(CV),
thickness
(CT),
surface
area
(CSA).
examined
sex-specific
differences
these
associations.
Results
Higher
concentration
was
lower
GMV
(MCPP:
(−1.73
cm
3
,
95%
CI:
−3.36,
−0.10)
higher
WMV
(∑DEHP:
2.28
0.08,
4.48).
boys
(n=72,
140
sMRIs),
MEP
(−2.97
−5.85,
−0.09)
MiBP
(−2.40
−4.64,
−0.15)
also
GMV.
girls
(n=85,
229
MRIs),
∑DINCH
(2.27
0.29,
4.25).
observed
significant
sex
interactions
∑DEHP
(p-interaction=0.03)
(p-interaction=0.001).
Conclusion
Early
phthalate/plasticizer
may
differentially
impact
various
region
volumes
childhood,
potential
downstream
consequences
functional
development.
NeuroToxicology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Air
pollutants
have
been
associated
with
various
neurodevelopmental
disorders,
several
studies
specifically
linking
Particulate
Matter
(PM)
exposure
to
attentional
and
social
deficits.
This
link
is
even
more
pronounced
when
occurs
during
the
prenatal
period,
as
it
can
disrupt
normal
brain
development.
However,
while
deficits
extensively
studied
adolescence,
their
impact
on
adult
behaviors
remains
largely
unexplored.
To
investigate
these
effects,
pregnant
Wistar
rats
were
exposed
throughout
gestation
(GD1-GD21)
PM10
at
a
dosage
of
200μg/Kg/day
diluted
in
PBS
that
was
freely
drunk.
After
birth,
pups
evaluated
developmental
milestones
such
weight
progression,
ocular
opening,
muscular
strength.
In
adulthood,
inhibitory
control
assessed
using
Five
Choice
Serial
Reaction
Time
Task
(5-CSRTT),
behavior
Three-Chambered
Crawley's
Test
(3-CT),
object
recognition
Novelty
Object
Recognition
test
(NOR).
The
results
indicated
higher
birth
poorer
performance
neuromuscular
tests.
no
significant
differences
observed
(5-CSRTT)
or
(3-CT).
Interestingly,
prenatally
rodents
showed
heightened
novelty
responses
NOR
test.
conclusion,
gestational
related
milestones,
including
While
does
not
behavior,
influences
later
life.
