Association between Prenatal Dietary Toxicants and Infant Neurodevelopment: The Role of Fish DOI Creative Commons
Xiruo Kou, Nerea Becerra‐Tomás, Josefa Canals

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(5), P. 338 - 338

Published: May 6, 2024

More research is needed to understand how the maternal consumption of fish and fish-borne toxicants impacts infant neurodevelopment. The present analysis was conducted over 460 mother–infant pairs within ECLIPSES study. Dietary intake metals persistent organic pollutants from (including white fish, blue seafood) estimated in pregnant women. infants underwent cognitive, language, motor function assessments using Bayley Scales Infant Development-III at 40-day postpartum. Associations between dietary outcomes were assessed multivariable linear regression models. Estimated prenatal exposure toxicants, such as arsenic, inorganic methylmercury, dioxin-like polychlorinated biphenyls (DL-PCBs), non-DL-PCBs, associated with poorer language functions infants, whereas no significant associations found or cognitive functions. Maternal exceeding Spanish recommendation more than 71 g per day linked these adverse effects on abilities without affecting development. This highlights importance vigilant monitoring environmental provision guidance for women, potential implications public health child

Language: Английский

Dysregulation of microRNA (miRNA) Due to Phthalate/Phthalate Metabolite Exposure and Associated Health Effects: A Narrative Review DOI Creative Commons

A. K. A. MOHAMMED,

Stephen L. Atkin, Edwina Brennan

et al.

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(3), P. 72 - 72

Published: May 12, 2025

Phthalates, a group of synthetic non-persistent organic chemicals commonly used as solvents and plasticisers, have been associated with range detrimental health effects. These endocrine disrupting (ECDs) may exert their effects through epigenetic changes such altered microRNA (miRNA) expression. miRNAs are short non-coding endogenous RNA transcripts that preferentially expressed in various tissues cell types can circulate body fluids, thereby regulating gene expression acting mediators for intercellular communication. As mostly target protein-coding transcripts, they involved nearly all networks regulate developmental pathological processes. In this review, we provide an overview human, vivo vitro studies assessing miRNA due to phthalate exposure biological Importantly, study suggests the mechanism action part be mediated by changes, affecting large number different proteins. This is indicative alterations induced then implicated wide conditions, including reproductive dysfunction, oncogenesis, metabolic disorders, neurodevelopmental outcomes. Exposure phthalates metabolites predominantly results upregulation miRNAs. Dysregulation miR-34a, miR-15b, miR-141, miR-184, miR-19a, miR-125, miR-let-7 were observed across several studies. More research involving human participants combined mechanistic integrating mRNA analysis would beneficial understanding downstream on grasping broader implications.

Language: Английский

Citations

0
Current perspectives on perinatal mental health and neurobehavioral development: focus on regulation, coregulation and self-regulation DOI
Bea Van den Bergh, Marta C. Antonelli, Dan J. Stein

et al.

Current Opinion in Psychiatry, Journal Year: 2024, Volume and Issue: 37(3), P. 237 - 250

Published: Feb. 19, 2024

Perinatal mental health research provides an important perspective on neurobehavioral development. Here, we aim to review the association of maternal perinatal with offspring neurodevelopment, providing update (self-)regulation problems, hypothesized mechanistic pathways, progress and challenges, implications for health.

Language: Английский

Citations

3
Interaction of prenatal maternal selenium and manganese levels on child neurodevelopmental trajectories-the Shanghai birth cohort study DOI Creative Commons
Xiangrong Guo, Jian Xu, Ying Tian

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 915, P. 170095 - 170095

Published: Jan. 16, 2024

The fetal brain is particularly plastic, and may be concurrently affected by chemical exposure malnutritional factors. Selenium essential for the developing brain, excess manganese exert neurotoxic effects. However, few epidemiological studies have evaluated interaction of selenium assessed in different prenatal stages on postnatal neurodevelopmental trajectories. This study contained 1024 mother-child pairs Shanghai-birth-cohort from 2013 to 2016 recruited since early/before pregnancy with complete data levels infant Whole blood early around birth were measured inductively-coupled-plasma-mass-spectrometry (ICP-MS), children's cognitive development was at 6, 12, 24 months age using Age & Stage-Questionnaire (ASQ)-3 Bayley-III. Multiple linear regression used investigate 1.82 ± 0.98 μg/dL 13.53 2.70 maternal pregnancy, 5.06 1.67 11.81 3.35 umbilical cord blood, respectively. Higher Se associated better neurocognitive performances or consistently-high-level trajectory (P < 0.05), more significant associations observed than birth. such positive relationships became non-significant even adverse high (vs. low) status, effect differences between low pregnancy. Prenatal positively child neurodevelopment, but mitigate favorable effects mainly earlier stage.

Language: Английский

Citations

2
Development of a novel NIR-II fluorescence probe for monitoring serum albumin fluctuation in cerebra neurotoxicity induced by Manganese exposure DOI
Xing Liang,

Luolin Wang,

Lizhen Xu

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 485, P. 136936 - 136936

Published: Dec. 18, 2024

Language: Английский

Citations

2
hPSCs-derived brain organoids for disease modeling, toxicity testing and drug evaluation DOI
Na Xie, Jinrong Bai,

Ya Hou

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 385, P. 115110 - 115110

Published: Dec. 10, 2024

Language: Английский

Citations

2
Neurodevelopmental consequences of gestational exposure to particulate matter 10: Ultrasonic vocalizations and gene expression analysis using a bayesian approach DOI
Diego Ruiz-Sobremazas,

Mario Coca,

Miguel Morales-Navas

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 240, P. 117487 - 117487

Published: Nov. 1, 2023

Language: Английский

Citations

4
Are the new phthalates safe? Evaluation of Diisononilphtalate (DINP) effects in porcine ovarian cell cultures DOI Creative Commons
Giuseppina Basini,

Simona Bussolati,

Stefano Grolli

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 106, P. 104384 - 104384

Published: Feb. 6, 2024

Phthalates are plasticizing chemicals, widely used in packaging materials and consumer products for several decades. These molecules have raised concerns because of their toxicity use been restricted countries. Therefore, novel phthalates introduced. Among these, diisononilphtalate (DINP) is employed. However, its safety has not properly addressed. using a well validated granulosa cell model, collected from swine ovaries with translational value, we studied potential DINP effects on important cellular functional parameters. In particular, growth, steroidogenesis redox status. Collected data showed that stimulates (p<0.05) increases estrogen inhibits progesterone production (P < 0.05), disrupts balance stimulating free radicals while reducing scavenger activities (P<0.05). Taken together, DINP's impact cultured cells provide cause concern regarding adverse reproductive endocrine functions.

Language: Английский

Citations

1
Association between urinary BTEX metabolites and dyslexic odds among school-aged children DOI
Rundong Liu, Yanjian Wan,

Bing Zhu

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(21), P. 31443 - 31454

Published: April 17, 2024

Language: Английский

Citations

1
Chemical and non-chemical stressors in a postpartum cohort through wristband and self report data: Links between increased chemical burden, economic, and racial stress DOI Creative Commons
Elise Hickman, J Frey, Amanda Wylie

et al.

Environment International, Journal Year: 2024, Volume and Issue: 191, P. 108976 - 108976

Published: Aug. 24, 2024

• Combined chemical and social stress exposure assessments are needed. The postpartum period is an often overlooked window of susceptibility. Chemical was different across races amongst participants. Clustering identified co-exposure to certain groups stress. Further investigation needed understand sources differential exposure. Multiple external stressors known have adverse impacts on health development. Certain more vulnerable and/or likely be exposed environmental, psychological, simultaneously. Yet, few studies examined combined environmental toxicants psychosocial Here, we integrated data collected using silicone wristbands self-report stressor within the Brain Early Experience (BEE) perinatal cohort chemicals Silicone were worn for one week by mothers throughout central North Carolina who 6 months (n = 97). Exposure 110 eight classes quantified gas chromatography mass spectrometry. Social evaluated established questionnaires (e.g., Brief Symptom Inventory, Perceived Stress Scale), quantifying experiences such as race-related stress, economic strain, relationship conflict. Hair cortisol levels measured additional metric landscape associations among exposure, demographic characteristics, characterized through individual variable analyses, cluster reduction, compiled scoring approaches comprehensively evaluate burdens. We found that contain co-occurring patterns largely based class, with phthalates representing class highest polychlorinated biphenyls lowest. Chemicals showed racial groups, diethyl phthalate, triphenyl phosphate, tris(3,5-dimethyl phenyl) phosphate at higher in Black participants compared White Integrating profiling particularly subset which high burden coincided racism These findings demonstrate warranting further better how these may contribute disparities maternal child health.

Language: Английский

Citations

1
Advanced electrochemical detection methodologies for assessing neuroactive substance variability induced by environmental pollutants exposure DOI Creative Commons

Yuanyuan Cao,

Chengkai Yang, Chengshuai Liu

et al.

Environmental Technology & Innovation, Journal Year: 2024, Volume and Issue: unknown, P. 103965 - 103965

Published: Dec. 1, 2024

Language: Английский

Citations

1