Dietary index for gut microbiota is associated with stroke among US adults

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The dietary index for gut microbiota was inversely associated with stroke prevalence, particularly in adults aged 30 years and above.

Language: Английский

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Integration of 168,000 samples reveals global patterns of the human gut microbiome

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The factors shaping human microbiome variation are a major focus of biomedical research. While other fields have used large sequencing compendia to extract insights requiring otherwise impractical sample sizes, the field has lacked comparably sized resource for 16S rRNA gene amplicon commonly quantify composition. To address this gap, we processed 168,464 publicly available gut samples with uniform pipeline. We use compendium evaluate geographic and technical effects on variation. find that regions such as Central Southern Asia differ significantly from more thoroughly characterized microbiomes Europe Northern America composition alone can be predict sample's region origin. also strong associations between primers DNA extraction. anticipate growing work, Human Microbiome Compendium, will enable advanced applied methodological

Language: Английский

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Limosilactobacillus reuteri - a probiotic gut commensal with contextual impact on immunity

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 17, 2025

The gut microbiome plays a key role in human health, influencing various biological processes and disease outcomes. historical roots of probiotics are traced back to Nobel Laureate Élie Metchnikoff, who linked the longevity Bulgarian villagers their consumption sour milk fermented by Lactobacilli. His pioneering work led global recognition as beneficial supplements, now multibillion-dollar industry. Modern have been extensively studied for immunomodulatory effects. Limosilactobacillus reuteri (L. reuteri), widely used probiotic, has garnered significant attention its systemic immune-regulatory properties, particularly relation autoimmunity cancer. This review delves into L. modulating immune responses, with focus on impact diseases.

Language: Английский

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Critical Review of the Cross-Links Between Dietary Components, the Gut Microbiome, and Depression

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 614 - 614

Published: Jan. 13, 2025

The complex relationship between diet, the gut microbiota, and mental health, particularly depression, has become a focal point of contemporary research. This critical review examines how specific dietary components, such as fiber, proteins, fats, vitamins, minerals, bioactive compounds, shape microbiome influence microbial metabolism in order to regulate depressive outcomes. These dietary-induced changes microbiota can modulate production metabolites, which play vital roles gut–brain communication. axis facilitates this communication through neural, immune, endocrine pathways. Alterations metabolites central nervous system (CNS) functions by impacting neuroplasticity, inflammatory responses, neurotransmitter levels—all are linked onset course depression. highlights recent findings linking components with beneficial composition reduced symptoms. We also explore challenges individual variability responses interventions long-term sustainability these strategies. underscores necessity for further longitudinal mechanistic studies elucidate precise mechanisms diet interactions be leveraged mitigate paving way personalized nutritional therapies.

Language: Английский

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Microbes Saving Lives and Reducing Suffering

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Language: Английский

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Effects of Selected Food Additives on the Gut Microbiome and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 192 - 192

Published: Jan. 22, 2025

The purpose of this article is to present selected food additives as disruptors normal intestinal homeostasis with a potential impact on the development metabolic dysfunction-associated steatotic liver disease (MASLD). A comprehensive literature search was conducted in three major electronic databases: PubMed, ScienceDirect, and Google Scholar. MASLD prevalent condition that closely related global rise obesity. Its pathogenesis multifactorial, genetic, environmental, factors playing key role. “multiple-hit” hypothesis suggests Western-style diet, rich ultra-processed foods, saturated fats, additives, combined low physical activity, contributes obesity, which promotes lipid accumulation liver. Recent studies underscore role impaired MASLD. Food including preservatives, emulsifiers, sweeteners, affect gut health function. Selected preservatives inhibit pathogenic microorganisms but disrupt microbiota, leading changes permeability dysfunction. Some emulsifiers thickeners can cause inflammation alter microbiome, contributing steatosis. Furthermore, use sweeteners such sucralose aspartame has been linked metabolism microbial composition, turn disorders.

Language: Английский

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Clinical translation of microbiome research

Nature Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

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Study on the Effect of Radish Sprouts on Short-Chain Fatty Acids and Gut Microbial Diversity in Healthy Individuals

Foods, Journal Year: 2025, Volume and Issue: 14(2), P. 170 - 170

Published: Jan. 8, 2025

This study aimed to assess the impact of radish sprouts on gut microbiota healthy individuals. Radish sprout additives, subjected short-term storage and steam treatment, were used intervene in an vitro culture human microbiota. The influence was evaluated by monitoring short-chain fatty acid (SCFA) content proportion fermentation broth, microbial diversity assessed using 16S rDNA amplicon sequencing. results indicated that produced a substantial amount SCFA within 48 h fermentation, with right-skewed distribution across all groups. addition both digestates enhanced Firmicutes diversity, while Bacteroidetes Proteobacteria remained stable between control fresh 30 s treatment group showed increase decrease diversity. abundance Bacilli, Bacillaceae, Bacillus significantly higher steam-treated groups compared control. Both enriched showing superior effects. These findings suggest consumption may positively microbiota, potentially enhancing these benefits.

Language: Английский

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Macronutrient balance determines the human gut microbiome eubiosis: insights from in vitro gastrointestinal digestion and fermentation of eight pulse species

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 30, 2025

The interactions between macronutrients, the human gut microbiome, and their metabolites (short-chain fatty acids) were comprehensively investigated via an in vitro digestion fermentation model subjected to eight pulse species. 16S rRNA sequencing taxonomic analysis of digesta fermented for up 24 h revealed increase relative abundance health-detrimental genera represented by Escherichia-Shigella kidney bean, soybean, cowpea, chickpea, black bean samples. In contrast, health-positive genera, including Bacteroides , Eubacterium Akkermansia was elevated red mung Heunguseul. At same time, proportion pathogenic decreased. Concurrently, these three species exhibited microbial diversity as evidenced calculation α -diversity (Shannon index) β (Bray-Curtis distance). Despite lower nutrient contents pulses, carbohydrates, amino acids, network that possess complex positive or negative correlations with a variety bacteria, well metabolites. These more pronounced Heunguseul than other pulses. It postulated overall potential nourish environments due balance nutritional components. linear regression demonstrated there association carbohydrate acid Shannon indices. Furthermore, ratio carbohydrates acids displayed increase. showed weak correlation. is noteworthy diet comprising foods balanced profile supports growth beneficial microbes, thereby promoting eubiosis. Consistent work on different ingredients essential precise insight into interplay food microbiome dietary patterns.

Language: Английский

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The Role of the Gut Microbiota in Health, Diet, and Disease with a Focus on Obesity

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 492 - 492

Published: Feb. 4, 2025

The gut microbiota has been increasingly recognised as a critical determinant of human health, influencing wide range physiological processes. A healthy is essential for maintaining metabolic, immune, and gastrointestinal homeostasis, contributing to overall well-being. Alterations in its composition functionality, often referred microbial dysbiosis, are strongly associated with the development gut-related systemic diseases. synthesises several components interacts epithelial cell receptors, processes that extend beyond nutritional status pathogenesis diseases such obesity, which their known contribution status. Therefore, this state-of-the-art review findings from recent studies on composition, functions, factors microbiota, focus role obesity. systematic search peer-reviewed literature was conducted ensure comprehensive coverage, while expert insights incorporated discuss emerging research directions future perspectives field.

Language: Английский

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