Journal of Molecular Biology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 168985 - 168985
Published: Feb. 1, 2025
Queuosine
(Q),
a
7-deazaguanosine
derivative,
is
among
the
most
intricate
tRNA
modifications,
and
located
at
position
34
(the
Wobble
position)
of
tRNAs
with
GUN
anticodon.
Found
in
eukaryotes
many
bacteria,
Q
unique
modifications
because
its
full
biosynthetic
pathway
exists
only
bacteria.
In
contrast,
are
auxotrophic
for
Q,
relying
on
dietary
sources
gut
microbiota
to
acquire
nucleobase
queuine.
This
dependency
creates
nutritional
link
translation
host.
enhances
base
pairing
U
helps
balance
translational
speed
between
codons
ending
C
eukaryotes.
The
absence
modification
impacts
oxidative
stress
response,
impairs
mitochondrial
function
protein
folding,
has
been
associated
neurodegeneration,
cancer,
inflammation.
review
discusses
our
current
understanding
cellular
organismal
deficiency
Additionally,
it
examines
recent
advancements
technologies
detecting
single-base
resolution
explores
potential
applications
system
biotechnology.
Cell,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
factors
shaping
human
microbiome
variation
are
a
major
focus
of
biomedical
research.
While
other
fields
have
used
large
sequencing
compendia
to
extract
insights
requiring
otherwise
impractical
sample
sizes,
the
field
has
lacked
comparably
sized
resource
for
16S
rRNA
gene
amplicon
commonly
quantify
composition.
To
address
this
gap,
we
processed
168,464
publicly
available
gut
samples
with
uniform
pipeline.
We
use
compendium
evaluate
geographic
and
technical
effects
on
variation.
find
that
regions
such
as
Central
Southern
Asia
differ
significantly
from
more
thoroughly
characterized
microbiomes
Europe
Northern
America
composition
alone
can
be
predict
sample's
region
origin.
also
strong
associations
between
primers
DNA
extraction.
anticipate
growing
work,
Human
Microbiome
Compendium,
will
enable
advanced
applied
methodological
Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 17, 2025
The
gut
microbiome
plays
a
key
role
in
human
health,
influencing
various
biological
processes
and
disease
outcomes.
historical
roots
of
probiotics
are
traced
back
to
Nobel
Laureate
Élie
Metchnikoff,
who
linked
the
longevity
Bulgarian
villagers
their
consumption
sour
milk
fermented
by
Lactobacilli.
His
pioneering
work
led
global
recognition
as
beneficial
supplements,
now
multibillion-dollar
industry.
Modern
have
been
extensively
studied
for
immunomodulatory
effects.
Limosilactobacillus
reuteri
(L.
reuteri),
widely
used
probiotic,
has
garnered
significant
attention
its
systemic
immune-regulatory
properties,
particularly
relation
autoimmunity
cancer.
This
review
delves
into
L.
modulating
immune
responses,
with
focus
on
impact
diseases.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 614 - 614
Published: Jan. 13, 2025
The
complex
relationship
between
diet,
the
gut
microbiota,
and
mental
health,
particularly
depression,
has
become
a
focal
point
of
contemporary
research.
This
critical
review
examines
how
specific
dietary
components,
such
as
fiber,
proteins,
fats,
vitamins,
minerals,
bioactive
compounds,
shape
microbiome
influence
microbial
metabolism
in
order
to
regulate
depressive
outcomes.
These
dietary-induced
changes
microbiota
can
modulate
production
metabolites,
which
play
vital
roles
gut–brain
communication.
axis
facilitates
this
communication
through
neural,
immune,
endocrine
pathways.
Alterations
metabolites
central
nervous
system
(CNS)
functions
by
impacting
neuroplasticity,
inflammatory
responses,
neurotransmitter
levels—all
are
linked
onset
course
depression.
highlights
recent
findings
linking
components
with
beneficial
composition
reduced
symptoms.
We
also
explore
challenges
individual
variability
responses
interventions
long-term
sustainability
these
strategies.
underscores
necessity
for
further
longitudinal
mechanistic
studies
elucidate
precise
mechanisms
diet
interactions
be
leveraged
mitigate
paving
way
personalized
nutritional
therapies.
Medicina,
Journal Year:
2025,
Volume and Issue:
61(2), P. 192 - 192
Published: Jan. 22, 2025
The
purpose
of
this
article
is
to
present
selected
food
additives
as
disruptors
normal
intestinal
homeostasis
with
a
potential
impact
on
the
development
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD).
A
comprehensive
literature
search
was
conducted
in
three
major
electronic
databases:
PubMed,
ScienceDirect,
and
Google
Scholar.
MASLD
prevalent
condition
that
closely
related
global
rise
obesity.
Its
pathogenesis
multifactorial,
genetic,
environmental,
factors
playing
key
role.
“multiple-hit”
hypothesis
suggests
Western-style
diet,
rich
ultra-processed
foods,
saturated
fats,
additives,
combined
low
physical
activity,
contributes
obesity,
which
promotes
lipid
accumulation
liver.
Recent
studies
underscore
role
impaired
MASLD.
Food
including
preservatives,
emulsifiers,
sweeteners,
affect
gut
health
function.
Selected
preservatives
inhibit
pathogenic
microorganisms
but
disrupt
microbiota,
leading
changes
permeability
dysfunction.
Some
emulsifiers
thickeners
can
cause
inflammation
alter
microbiome,
contributing
steatosis.
Furthermore,
use
sweeteners
such
sucralose
aspartame
has
been
linked
metabolism
microbial
composition,
turn
disorders.
Foods,
Journal Year:
2025,
Volume and Issue:
14(2), P. 170 - 170
Published: Jan. 8, 2025
This
study
aimed
to
assess
the
impact
of
radish
sprouts
on
gut
microbiota
healthy
individuals.
Radish
sprout
additives,
subjected
short-term
storage
and
steam
treatment,
were
used
intervene
in
an
vitro
culture
human
microbiota.
The
influence
was
evaluated
by
monitoring
short-chain
fatty
acid
(SCFA)
content
proportion
fermentation
broth,
microbial
diversity
assessed
using
16S
rDNA
amplicon
sequencing.
results
indicated
that
produced
a
substantial
amount
SCFA
within
48
h
fermentation,
with
right-skewed
distribution
across
all
groups.
addition
both
digestates
enhanced
Firmicutes
diversity,
while
Bacteroidetes
Proteobacteria
remained
stable
between
control
fresh
30
s
treatment
group
showed
increase
decrease
diversity.
abundance
Bacilli,
Bacillaceae,
Bacillus
significantly
higher
steam-treated
groups
compared
control.
Both
enriched
showing
superior
effects.
These
findings
suggest
consumption
may
positively
microbiota,
potentially
enhancing
these
benefits.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 30, 2025
The
interactions
between
macronutrients,
the
human
gut
microbiome,
and
their
metabolites
(short-chain
fatty
acids)
were
comprehensively
investigated
via
an
in
vitro
digestion
fermentation
model
subjected
to
eight
pulse
species.
16S
rRNA
sequencing
taxonomic
analysis
of
digesta
fermented
for
up
24
h
revealed
increase
relative
abundance
health-detrimental
genera
represented
by
Escherichia-Shigella
kidney
bean,
soybean,
cowpea,
chickpea,
black
bean
samples.
In
contrast,
health-positive
genera,
including
Bacteroides
,
Eubacterium
Akkermansia
was
elevated
red
mung
Heunguseul.
At
same
time,
proportion
pathogenic
decreased.
Concurrently,
these
three
species
exhibited
microbial
diversity
as
evidenced
calculation
α
-diversity
(Shannon
index)
β
(Bray-Curtis
distance).
Despite
lower
nutrient
contents
pulses,
carbohydrates,
amino
acids,
network
that
possess
complex
positive
or
negative
correlations
with
a
variety
bacteria,
well
metabolites.
These
more
pronounced
Heunguseul
than
other
pulses.
It
postulated
overall
potential
nourish
environments
due
balance
nutritional
components.
linear
regression
demonstrated
there
association
carbohydrate
acid
Shannon
indices.
Furthermore,
ratio
carbohydrates
acids
displayed
increase.
showed
weak
correlation.
is
noteworthy
diet
comprising
foods
balanced
profile
supports
growth
beneficial
microbes,
thereby
promoting
eubiosis.
Consistent
work
on
different
ingredients
essential
precise
insight
into
interplay
food
microbiome
dietary
patterns.
Foods,
Journal Year:
2025,
Volume and Issue:
14(3), P. 492 - 492
Published: Feb. 4, 2025
The
gut
microbiota
has
been
increasingly
recognised
as
a
critical
determinant
of
human
health,
influencing
wide
range
physiological
processes.
A
healthy
is
essential
for
maintaining
metabolic,
immune,
and
gastrointestinal
homeostasis,
contributing
to
overall
well-being.
Alterations
in
its
composition
functionality,
often
referred
microbial
dysbiosis,
are
strongly
associated
with
the
development
gut-related
systemic
diseases.
synthesises
several
components
interacts
epithelial
cell
receptors,
processes
that
extend
beyond
nutritional
status
pathogenesis
diseases
such
obesity,
which
their
known
contribution
status.
Therefore,
this
state-of-the-art
review
findings
from
recent
studies
on
composition,
functions,
factors
microbiota,
focus
role
obesity.
systematic
search
peer-reviewed
literature
was
conducted
ensure
comprehensive
coverage,
while
expert
insights
incorporated
discuss
emerging
research
directions
future
perspectives
field.