Genetically Predicted Gut Microbiota Mediate the Association Between Fatty Acids and Intrahepatic Cholestasis of Pregnancy: A Mendelian Randomization Analysis DOI Creative Commons
Ling Li,

Zhiquan Qin,

Ruirui Dong

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 30, 2024

ABSTRACT Fatty acids (FAs) and gut bacteria likely play vital roles in intrahepatic cholestasis of pregnancy (ICP). However, the causal connection between FAs, microbiota, ICP has not yet been confirmed. To investigate associations bacteria, ICP, a Mendelian randomization (MR) analysis with two samples was performed to identify potential relationships FAs ICP. The mediating role analyzed by two‐step MR analysis. False discovery rate (FDR) correction conducted correct bias multiple tests. revealed that higher omega‐6 FAs/total (odds ratio [OR] = 2.563, 95% confidence interval [CI] 1.362–4.824, FDR p 0.016), linoleic acids/total (OR 3.812, 95%CI 1.966–7.388, 0.001), average number methylene groups 1.968, 1.390–2.785, 0.001) are risk factors for omega‐3 0.587, 0.394–0.874, 0.031) double bonds an FA chain 0.575, 0.435–0.759, could reduce abundance 25 showed significant effects on among which Dokdonella may crucial modulating Our research results suggest vary according their different types. plays interactions

Language: Английский

Lipidomics and genomics in mental health: insights into major depressive disorder, bipolar disorder, schizophrenia, and obsessive-compulsive disorder DOI Creative Commons
Martina Nicole Modesti, Jan Francesco Arena, Antonio Del Casale

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 11, 2025

This systematic review explores the hypothesis that various lipid categories and metabolism-related genomic variations link to mental disorders, seeking potential clinically useful markers. We searched PubMed, Scopus, PsycInfo databases until October 12th, 2024, using terms related lipidomics, lipid-related genomics, different i.e., Major Depressive Disorder (MDD), Bipolar (BD), Schizophrenia (SCZ), Obsessive–Compulsive (OCD). Eligible studies were assessed. Extracted data included author, year, methodology, outcomes, genes, lipids linked disorders. Bias evidence certainty evaluated. The adhered PRISMA (Preferred Reporting Items for Systematic Reviews Meta-Analyses) guidelines a registered protocol (PROSPERO: CRD42023438862). A total of 27 included. SCZ showed alterations in 77 lipids, including triglycerides (TG), ceramides, phosphatidylcholine, while MDD BD exhibited 97 47 altered respectively, with overlap among Shared such as ABCA13, DGKZ, FADS, pathways involving inflammation, metabolism, mitochondrial function identified. OCD was associated sphingolipid signaling peroxisomal metabolism. Lipid signatures MDD, BD, shed light on underlying processes. Further research is needed validate biomarkers refine their clinical applications precision psychiatry.

Language: Английский

Citations

1
Bidirectional causal associations between plasma metabolites and bipolar disorder DOI
Qian Zhao, Ancha Baranova, Dongming Liu

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

1
Biomarkers of bipolar disorder in omics and neuroimaging DOI Creative Commons
Donghua He,

Jingzhi Yang,

Zuowei Wang

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101264 - 101264

Published: March 1, 2025

Language: Английский

Citations

0
Mediation-adjusted multivariable Mendelian randomisation study identified novel metabolites related to mental health DOI Creative Commons
Dennis Freuer, Christa Meisinger

BMJ Mental Health, Journal Year: 2024, Volume and Issue: 27(1), P. e301230 - e301230

Published: Oct. 1, 2024

Background From the pathway perspective, metabolites have potential to improve knowledge about aetiology of psychiatric diseases. Previous studies suggested a link between specific blood and mental disorders, but some Mendelian randomisation (MR) in particular are insufficient for various reasons. Objective This study focused on bias assessment due interdependencies mediation effects. Methods In multistep framework containing network multivariable MR, direct effects 21 mutually adjusted 8 disorders were estimated based summary statistics genome-wide association from multiple resources. Robust inverse-variance weighted models used primary analyses. Several sensitivity analyses performed assess different patterns pleiotropy weak instrument bias. Estimates same phenotypes resources pooled using fixed effect meta-analysis models. Findings After adjusting effects, genetically predicted metabolite levels six lipid, amino acid cofactors pathways directly associated with overall (attention-deficit/hyperactivity disorder, bipolar anorexia nervosa, depression, post-traumatic stress disorder schizophrenia). Point estimates ranged −0.45 (95% CI −0.67; −0.24, p=1.0×10 4 ) 1.78 0.85; 2.71, p=0.006). No associations found anxiety suicide attempt. Conclusions provides insights into new metabolic that seems be causally related certain disorders. Clinical implications Further needed investigate whether identified itself or biochemical regulating metabolites.

Language: Английский

Citations

2
Plasma fatty acids and attention deficit hyperactivity disorder: a Mendelian randomization investigation DOI Creative Commons

Kangning Zhou,

Qiang Zhang,

Zhenhua Yuan

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: May 3, 2024

Background Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental of childhood, and pathogenesis not fully understood. Observational studies suggest an association between fatty acids abnormalities ADHD, but there are contradictions differences these findings. To address this uncertainty, we employed a two-sample bidirectional Mendelian Randomization (MR) analysis to investigate causal relationship ADHD. Methods We conducted study, selecting single nucleotide polymorphisms (SNPs) highly correlated with acid levels from CHARGE Consortium as our instruments. The outcome data were sourced Psychiatric Genomics (PGC) dataset on comprising 225,534 individuals, 162,384 cases 65,693 controls. Inverse variance weighting, MR-Egger, weighted median methods estimate Cochran’s Q-test was used quantify heterogeneity instrumental variables. Sensitivity analyses included MR-Egger intercept tests, leave-one-out analyses, funnel plots. Results MR revealed no significant associations genetically predicted various saturated, monounsaturated, polyunsaturated (including omega-3 omega-6) ADHD risk in PGC cohorts. Notably, initial Dihomo-gamma-linolenic (DGLA) (OR = 1.009, p 0.032 by IVW) did persist after correction for multiple testing (adjusted -value 0.286). supported findings, indicating robustness. Moreover, lack evidence supporting link acids. Conclusion While study basis genetic does provide support role it preclude their potential involvement reducing Further research needed explore possibility.

Language: Английский

Citations

1
Association between 15 Insertion/Deletion Polymorphisms and the Risk of Type 1 Bipolar Disorder DOI Creative Commons

Fatemeh Zebarjad,

Mostafa Saadat

Gene Expression, Journal Year: 2024, Volume and Issue: 000(000), P. 000 - 000

Published: July 5, 2024

Background and objectivesType 1 bipolar disorder (BP) is a mental illness characterized by extreme shifts in mood, oscillating between manic depressive episodes. It ranks as the sixth most prevalent psychiatric globally, often emerging teenage years. This study aimed to identify associations BP 15 insertion/deletion (Indel) polymorphisms human genome, examining genes including TPA, UCP2, HLA-G, FADS2, ADRA2B, VEGF, PDCD6IP, SLC6A4, TLR2, APOB, TP53, LRPAP1, DHFR, MDM2, DBH.

Language: Английский

Citations

1
Novel Approaches to Mortierella alpina Identification and Arachidonic Acid Production Optimization DOI Creative Commons

Violette Said Hanna,

Mohamed N. Abd El-Ghany, Mohamed Ibrahim

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(32), P. 34456 - 34463

Published: Aug. 1, 2024

Arachidonic acid (ARA) is an integral constituent of cell structures and instrumental for the nervous, muscular, immune systems' functions. The sore need this nutrient may be fulfilled via production based on fungus

Language: Английский

Citations

1
Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders DOI Creative Commons
Lachlan Gilchrist, Julian Mutz, Pirro G. Hysi

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Evidence indicates phenotypic and biological overlap between psychiatric neurodegenerative disorders. Further identification of underlying mutual unique mechanisms may yield novel multi-disorder disorder-specific therapeutic targets. The metabolome represents an important domain for target as metabolites play critical roles in modulating a diverse range processes. Here, we used Mendelian randomisation (MR) to test the causal effects ∼1000 plasma ∼300 metabolite ratios on anxiety, bipolar disorder, depression, schizophrenia, amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease multiple sclerosis. In total, 85 involving 77 passed FDR correction robust sensitivity analyses (IVW-MR OR range: 0.73-1.48; p < 0.05). No evidence reverse causality was identified. Multivariate implicated sphingolipid metabolism disorder risk carnitine derivatives sclerosis However, polygenic scores prioritised showed limited prediction UK Biobank. Downstream colocalisation regions containing influential variants identified greater than suggestive (PP.H4 ≥ 0.6) shared variant 29 metabolite/psychiatric trait-pairs chromosome 11 at FADS gene cluster. Most these were lipids linoleic or arachidonic acid. Additional ratio histidine-to-glutamine, glutamine, SPRYD4 expression 12. Although no single had effect results suggest broad across brain Metabolites here help inform future targeted interventions.

Language: Английский

Citations

0
The role of fatty acids in the emotional well-being of young adults: associations between fatty acid levels and symptoms of depression, anxiety, stress, and sleep disturbances DOI Creative Commons
Hanna Karakuła‐Juchnowicz, Agnieszka Banaszek, Ryszard Sitarz

et al.

Postępy Psychiatrii i Neurologii, Journal Year: 2024, Volume and Issue: 33(4), P. 201 - 212

Published: Jan. 1, 2024

Young adults experience high stress levels, leading to mood disorders. This study investigates the associations between specific fatty acid lipid profiles, inflammatory markers, and emotional well-being among young adults. Seventy-two aged 18-35 participated in this study. Participants completed self-assessments of depression severity (PHQ-9), (PSS-10), insomnia (ISI), anxiety (GAD-7). Blood samples were collected analyzed for plasma C-reactive protein (CRP) kynurenine pathway metabolites. Classification Regression Tree (C&RT) multivariate stepwise regression analyses employed identify potential predictors mental health outcomes. The revealed significant certain acids, conditions. Lauric acid, myristic eicosatrienoic identified as indicators issues. Higher levels palmitoleic linked increased depressive symptoms, while higher oleic associated with reduced depression. Anxiety was influenced by myristoleic docosahexaenoic acid. Stress sleep disturbances correlated acids. models explained a percentage variability outcomes, accounting 25% both symptoms anxiety, 23% stress, 43% disturbances. Specific kynurenic CRP, significantly impact Monitoring biomarkers may assist managing Personalized dietary interventions could improve quality. Further research is needed confirm these findings establish causal relationships.

Language: Английский

Citations

0
Genetically Predicted Gut Microbiota Mediate the Association Between Fatty Acids and Intrahepatic Cholestasis of Pregnancy: A Mendelian Randomization Analysis DOI Creative Commons
Ling Li,

Zhiquan Qin,

Ruirui Dong

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 30, 2024

ABSTRACT Fatty acids (FAs) and gut bacteria likely play vital roles in intrahepatic cholestasis of pregnancy (ICP). However, the causal connection between FAs, microbiota, ICP has not yet been confirmed. To investigate associations bacteria, ICP, a Mendelian randomization (MR) analysis with two samples was performed to identify potential relationships FAs ICP. The mediating role analyzed by two‐step MR analysis. False discovery rate (FDR) correction conducted correct bias multiple tests. revealed that higher omega‐6 FAs/total (odds ratio [OR] = 2.563, 95% confidence interval [CI] 1.362–4.824, FDR p 0.016), linoleic acids/total (OR 3.812, 95%CI 1.966–7.388, 0.001), average number methylene groups 1.968, 1.390–2.785, 0.001) are risk factors for omega‐3 0.587, 0.394–0.874, 0.031) double bonds an FA chain 0.575, 0.435–0.759, could reduce abundance 25 showed significant effects on among which Dokdonella may crucial modulating Our research results suggest vary according their different types. plays interactions

Language: Английский

Citations

0