Zweifach–Fung Microfluidic Device for Efficient Microparticle Separation: Cost-Effective Fabrication Using CO2 Laser-Ablated PMMA

Micromachines, Journal Year: 2024, Volume and Issue: 15(7), P. 932 - 932

Published: July 22, 2024

Microfluidic separators play a pivotal role in the biomedical and chemical industries by enabling precise fluid manipulations. Traditional fabrication of these devices typically requires costly cleanroom facilities, which limits their broader application. This study introduces novel microfluidic device that leverages passive Zweifach–Fung principle to overcome financial barriers. Through Lagrangian computational simulations, we optimized an eleven-channel configuration achieved perfect 100% recall rate for particles following specified normal distribution. Experimental evaluations determined 2 mL/h as optimal total flow (TFR), under showcased exceptional performance enhancements precision micrometer-sized particles, achieving overall accuracy 94% ± 3%. Fabricated using cost-effective, non-cleanroom method, this approach represents significant shift from conventional practices, dramatically reducing production costs while maintaining high operational efficacy. The cost each chip is less than USD 0.90 cents manufacturing process takes only 15 min. development not makes technology more accessible but also sets new standard future advancements field.

Language: Английский

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Inhibiting overgrowth of filamentous fungi by magnetic powders: Combination effects of particle interface toxicity and magnetic microbe

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159875 - 159875

Published: Jan. 1, 2025

Language: Английский

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Freeze–Thaw Imaging for Microorganism Classification Assisted with Artificial Intelligence

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Fast and cost-effective microbial classification is crucial for clinical diagnosis, environmental monitoring, food safety. However, traditional methods encounter challenges including intricate procedures, skilled personnel needs, sophisticated instrumentations. Here, we propose a microbe system, also termed freeze-thaw-induced floating pattern of AuNPs (FTFPA), coupled with artificial intelligence, which capable identifying microbes at cost $0.0023 per sample. Specifically, FTFPA utilizes coincubation microbes, resulting in distinct patterns upon freeze-thawing due to their weak interaction. These are digitized train models that distinguish nine various tasks. The positive sample detection model achieved an F1 score 0.976 (n = 194), while the multispecies task reached macro 0.859 1728). To address scalability lightweight requirements across diverse scenarios, categorized based on species levels. hierarchical 5184), order level Enterobacteriales 2550), Bacillales 1974) was 0.854, 0.907, 0.958, 0.843. In summary, our method user-friendly, requiring only simple equipment, easy operate, convenient, providing platform identification.

Language: Английский

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Magnetic particles–integrated microfluidics: from physical mechanisms to biological applications

Reviews in Chemical Engineering, Journal Year: 2024, Volume and Issue: 40(8), P. 1023 - 1072

Published: Oct. 22, 2024

Abstract Magnetic nanoparticles (MNPs) have garnered significant attention in biomedical applications. Due to their large surface area and tunable properties, MNPs are used microfluidic systems, which allow for the manipulation control of fluids at micro- or nanoscale. Using systems allows a faster, less expensive, more efficient approach applications like bioanalysis. microfluidics can precisely identify detect bioanalytes on single chip by controlling analytes conjunction with magnetic particles (MPs) separating various analytical functions nanoscales. Numerous uses these instruments, including cell-based research, proteomics, diagnostics, been reported. The successful reduction size assays creation compact LOC platforms made possible assistance microfluidics. Microfluidics is highly effective method manipulating as continuous flow discrete droplets. Since implementation technology, methods developed improve efficiency precision sorting, separating, isolating cells microparticles from original samples. These techniques aim surpass traditional laboratory procedures. This review focuses recent progress utilizing that incorporate biological

Language: Английский

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