Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(19), P. 11488 - 11558

Published: Sept. 25, 2023

The eye contains a complex network of physiological information and biomarkers for monitoring disease managing health, ocular devices can be used to effectively perform point-of-care diagnosis management. This comprehensive review describes the target various diseases, including ophthalmic metabolic neurological based on anatomical background eye. also includes recent technologies utilized in eye-wearable medical latest trends wearable devices, specifically smart contact lenses purpose After introducing other such as retinal prosthesis, we further discuss current challenges potential possibilities lenses.

Language: Английский

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The convergence of traditional and digital biomarkers through AI-assisted biosensing: A new era in translational diagnostics?

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 235, P. 115387 - 115387

Published: May 11, 2023

Advances in consumer electronics, alongside the fields of microfluidics and nanotechnology have brought to fore low-cost wearable/portable smart devices. Although numerous devices that track digital biomarkers been successfully translated from bench-to-bedside, only a few follow same fate when it comes traditional biomarkers. Current practices still involve laboratory-based tests, followed by blood collection, conducted clinical setting as they require trained personnel specialized equipment. In fact, real-time, passive/active robust sensing physiological behavioural data patients can feed artificial intelligence (AI)-based models significantly improve decision-making, diagnosis treatment at point-of-procedure, circumventing conventional methods sampling, person investigation expert pathologists, who are scarce developing countries. This review brings together biomarker through portable autonomous miniaturized We first summarise technological advances each field vs current we conclude merging two worlds AI/ML technologies patient treatment. The fundamental role, limitations prospects AI realizing this potential enhancing existing facilitate development translation "point-of-care" (POC) diagnostics is finally showcased.

Language: Английский

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Applications of Graphene in Five Senses, Nervous System, and Artificial Muscles

ACS Sensors, Journal Year: 2023, Volume and Issue: 8(2), P. 482 - 514

Published: Jan. 19, 2023

Graphene remains of great interest in biomedical applications because biocompatibility. Diseases relating to human senses interfere with life satisfaction and happiness. Therefore, the restoration by artificial organs or sensory devices may bring a bright future recovery patients. In this review, we update most recent progress graphene based sensors for mimicking such as retina image sensors, eardrums, gas chemical tactile sensors. The brain-like processors are discussed on conventional transistors well memristor related neuromorphic computing. brain–machine interface is introduced providing single pathway. Besides, muscles summarized means actuators order react physical world. Future opportunities remain elevating performances human-like their clinical applications.

Language: Английский

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Wearable and implantable bioelectronics as eco‐friendly and patient‐friendly integrated nanoarchitectonics for next‐generation smart healthcare technology

EcoMat, Journal Year: 2023, Volume and Issue: 5(8)

Published: May 8, 2023

Abstract Since the beginning of human history, demand for effective healthcare systems diagnosis and treatment health problems has grown steadily. However, traditional centralized requires hospital visits, making in‐time long‐term challenging. Bioelectronics shown potential in patient‐friendly owing to rapid advances diverse fields biology electronics. In particular, wearable implantable bioelectronics have emerged as an alternative or adjunct conventional healthcare. To develop into next‐generation systems, however, custom designs biological targets with a deepened understanding intrinsic features target are essential. addition, bioelectronic must be designed eco‐friendly sustainable this review, integrated nanoarchitectonics smart technology described. For in‐depth guidelines target‐tailored design, we discuss target‐specific considerations relevant key parameters representative examples. image

Language: Английский

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Challenges and Advances of Hydrogel-Based Wearable Electrochemical Biosensors for Real-Time Monitoring of Biofluids: From Lab to Market. A Review

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(20), P. 8160 - 8183

Published: Feb. 20, 2024

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTChallenges and Advances of Hydrogel-Based Wearable Electrochemical Biosensors for Real-Time Monitoring Biofluids: From Lab to Market. A ReviewHossein ChenaniHossein ChenaniDepartment Materials Science Engineering, Sharif University Technology, 14588 89694 Tehran, IranMore by Hossein ChenaniView Biographyhttps://orcid.org/0009-0009-6924-6491, Mohsen Saeidi*Mohsen SaeidiDepartment Iran*Tel: +98-21-6616 5262; Fax: +98-21-6600 5717; Email: [email protected]More SaeidiView Biographyhttps://orcid.org/0000-0001-5430-3339, MahsaSadat Adel RastkhizMahsaSadat RastkhizDepartment RastkhizView Biographyhttps://orcid.org/0009-0002-6628-6868, Nafiseh BolghanabadiNafiseh BolghanabadiDepartment BolghanabadiView Biographyhttps://orcid.org/0009-0004-1151-2201, Amir AghaiiAmir AghaiiDepartment AghaiiView Biographyhttps://orcid.org/0009-0006-2561-9119, Mina OroujiMina OroujiDepartment OroujiView Biographyhttps://orcid.org/0009-0007-6375-6437, HatamieAmir HatamieDepartment Chemistry Molecular Biology, Gothenburg, Sweden; Department Chemistry, Institute Advanced Studies in Basic Sciences (IASBS), Prof. Sobouti Boulevard, PO Box 45195-1159, Zanjan 45137-66731, HatamieView Biographyhttps://orcid.org/0000-0002-7085-893X, Abdolreza Simchi*Abdolreza SimchiDepartment IranCenter Bioscience Convergence Tehran 14588-89694, 5226; SimchiView Biographyhttps://orcid.org/0000-0002-9111-2977Cite this: Anal. Chem. 2024, 96, 20, 8160–8183Publication Date (Web):February 2024Publication History Received2 September 2023Accepted1 February 2024Revised24 January 2024Published online20 inissue 21 May 2024https://pubs.acs.org/doi/10.1021/acs.analchem.3c03942https://doi.org/10.1021/acs.analchem.3c03942review-articleACS PublicationsCopyright © 2024 American Chemical SocietyRequest reuse permissionsArticle Views1518Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biotechnology,Carbohydrates,Electrodes,Hydrogels,Sensors Get e-Alerts

Language: Английский

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Revolutionary Point‐of‐Care Wearable Diagnostics for Early Disease Detection and Biomarker Discovery through Intelligent Technologies

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Early-stage disease detection, particularly in Point-Of-Care (POC) wearable formats, assumes pivotal role advancing healthcare services and precision-medicine. Public benefits of early detection extend beyond cost-effectively promoting outcomes, to also include reducing the risk comorbid diseases. Technological advancements enabling POC biomarker recognition empower discovery new markers for various health conditions. Integration wearables with intelligent frameworks represents ground-breaking innovations automation operations, conducting advanced large-scale data analysis, generating predictive models, facilitating remote guided clinical decision-making. These substantially alleviate socioeconomic burdens, creating a paradigm shift diagnostics, revolutionizing medical assessments technology development. This review explores critical topics recent progress development 1) systems solutions physiological monitoring, as well 2) discussing current trends adoption smart technologies within settings developing biological assays, ultimately 3) exploring utilities platforms discovery. Additionally, translation from research labs broader applications. It addresses associated risks, biases, challenges widespread Artificial Intelligence (AI) integration diagnostics systems, while systematically outlining potential prospects, challenges, opportunities.

Language: Английский

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Wireless Battery-free and Fully Implantable Organ Interfaces

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2205 - 2280

Published: Feb. 21, 2024

Advances in soft materials, miniaturized electronics, sensors, stimulators, radios, and battery-free power supplies are resulting a new generation of fully implantable organ interfaces that leverage volumetric reduction mechanics by eliminating electrochemical storage. This device class offers the ability to provide high-fidelity readouts physiological processes, enables stimulation, allows control over organs realize therapeutic diagnostic paradigms. Driven seamless integration with connected infrastructure, these devices enable personalized digital medicine. Key advances carefully designed material, electrophysical, electrochemical, electromagnetic systems form implantables mechanical properties closely matched target deliver functionality supports sensors stimulators. The elimination operation, anywhere from acute, lifetimes matching subject physical dimensions imperceptible operation. review provides comprehensive overview basic building blocks related topics such as implantation, delivery, sterilization, user acceptance. State art examples categorized system an outlook interconnection advanced strategies for computation leveraging consistent influx elevate this current battery-powered is highlighted.

Language: Английский

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A Review of Recent Advances in Microneedle-Based Sensing within the Dermal ISF That Could Transform Medical Testing

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(3), P. 1149 - 1161

Published: March 13, 2024

Interstitial fluid (ISF) has attracted extensive attention in an extremely wide range of areas due to its unique advantages, such as portability, high precision, comfortable operation, and superior stability. In recent years, the microneedle (MN) technique been considered be excellent tool for extracting ISF because it is painless noninvasive. Recent reports have shown that MN good application prospects extraction. this review, we provide comprehensive in-depth insight into integrated devices detection, covering basic structure well fabrication various applications Challenges are highlighted, with a discussion on how transition MN-integrated toward personalized healthcare monitoring systems.

Language: Английский

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Photonic Nanomaterials for Wearable Health Solutions

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract This review underscores the transformative potential of photonic nanomaterials in wearable health technologies, driven by increasing demands for personalized monitoring. Their unique optical and physical properties enable rapid, precise, sensitive real‐time monitoring, outperforming conventional electrical‐based sensors. Integrated into ultra‐thin, flexible, stretchable formats, these materials enhance compatibility with human body, enabling prolonged wear, improved efficiency, reduced power consumption. A comprehensive exploration is provided integration devices, addressing material selection, light‐matter interaction principles, device assembly strategies. The highlights critical elements such as form factors, sensing modalities, data communication, representative examples skin patches contact lenses. These devices precise monitoring management biomarkers diseases or biological responses. Furthermore, advancements approaches have paved way continuum care systems combining multifunctional sensors therapeutic drug delivery mechanisms. To overcome existing barriers, this outlines strategies design, engineering, system integration, machine learning to inspire innovation accelerate adoption next‐generation health, showcasing their versatility digital applications.

Language: Английский

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Applications of Microwaves in Medicine

IEEE Journal of Microwaves, Journal Year: 2022, Volume and Issue: 3(1), P. 134 - 169

Published: Dec. 19, 2022

Advances and updates in medical applications utilizing microwave techniques technologies are reviewed this paper. The article aims to provide an overview of enablers for their recent progress. emphasis focuses on the microwaves, following order, 1) signal data communication implants wearables through human body, 2) electromagnetic energy transfer tissues, 3) noninvasive, remote or in situ physical biochemical sensing, 4) therapeutic purposes by changing tissue properties with controlled thermal effects. For wireless power transfer, implant wearable discussed categories pacemakers, endoscopic capsules, brain interfaces, intraocular, cardiac intracranial pressure sensors, neurostimulators, endoluminal implants, artificial retina, smart lenses, cochlear implants. noninvasive vital sign radar, biological cell probing, magnetic resonance imaging, biochemical, blood glucose, hydration biomarker sensing introduced. uses, developments ablation, balloon angioplasty, hyperthermia reviewed. scopes mainly concentrate research development efforts past 20 years. Recent review articles specific topics cited accomplishment highlights trends deliberated. At end article, a brief history IEEE Microwave Theory Techniques Society (MTT-S) Biological Effects Medical Applications committee contributions its members promotion advancement fields chronicled.

Language: Английский

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