Sensing and Bio-Sensing Research,
Journal Year:
2023,
Volume and Issue:
43, P. 100608 - 100608
Published: Nov. 28, 2023
The
interaction
of
mesenchymal
stromal
cells
(MSC)
in
co-cultures
with
hematopoietic
progenitor
(HPC)
ex-vivo
models
induce
the
secretion
pro-inflammatory
protein
factors
and
influences
HPC
cell
proliferation
differentiation
processes.
Different
studies
have
shown
quantification
these
biomarkers
other
conditioned
media
using
an
ELISA
Luminex™
type
immunoassay
format.
In
this
paper,
we
developed
real-time
from
bone
marrow,
umbilical
cord
blood,
Wharton's
jelly
sources
surface
plasmon
resonance
imaging
(SPRi).
We
show
detection
CCL2,
CCL5,
bFGF,
IL-6,
IL-8
VEGF
proteins
high
sensitivity
specificity.
SPRi
can
be
used
a
analysis
methodology
could
considered
tool
for
biomarker
assays.
Sensors,
Journal Year:
2023,
Volume and Issue:
23(12), P. 5406 - 5406
Published: June 7, 2023
Micro-
and
nanotechnology-enabled
sensors
have
made
remarkable
advancements
in
the
fields
of
biomedicine
environment,
enabling
sensitive
selective
detection
quantification
diverse
analytes.
In
biomedicine,
these
facilitated
disease
diagnosis,
drug
discovery,
point-of-care
devices.
environmental
monitoring,
they
played
a
crucial
role
assessing
air,
water,
soil
quality,
as
well
ensured
food
safety.
Despite
notable
progress,
numerous
challenges
persist.
This
review
article
addresses
recent
developments
micro-
for
biomedical
challenges,
focusing
on
enhancing
basic
sensing
techniques
through
micro/nanotechnology.
Additionally,
it
explores
applications
addressing
current
both
domains.
The
concludes
by
emphasizing
need
further
research
to
expand
capabilities
sensors/devices,
enhance
sensitivity
selectivity,
integrate
wireless
communication
energy-harvesting
technologies,
optimize
sample
preparation,
material
selection,
automated
components
sensor
design,
fabrication,
characterization.
Biosensors,
Journal Year:
2023,
Volume and Issue:
13(2), P. 163 - 163
Published: Jan. 20, 2023
Spread
of
coronavirus
disease
2019
(COVID-19)
has
significantly
impacted
the
public
health
and
economic
sectors.
It
is
urgently
necessary
to
develop
rapid,
convenient,
cost-effective
point-of-care
testing
(POCT)
technologies
for
early
diagnosis
control
plague’s
transmission.
Developing
POCT
methods
related
devices
critical
achieving
diagnosis.
With
advantages
miniaturization,
high
throughput,
small
sample
requirements,
low
actual
consumption,
microfluidics
an
essential
technology
development
devices.
In
this
review,
according
different
driving
forces
fluid,
we
introduce
common
based
on
microfluidic
market,
including
paper-based
microfluidic,
centrifugal
optical
digital
platforms.
Furthermore,
various
microfluidic-based
assays
diagnosing
COVID-19
are
summarized,
immunoassays,
such
as
ELISA,
molecular
assays,
PCR.
Finally,
challenges
future
perspectives
device
design
presented.
The
ultimate
goals
paper
provide
new
insights
directions
diagnostics
while
expecting
contribute
COVID-19.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 6958 - 6968
Published: March 27, 2024
In
recent
decades,
there
has
been
a
strong
and
growing
interest
in
developing
strategies
to
engineer
materials
with
tailored
optical
plasmonic
properties.
the
plethora
of
geometries
studied
proposed
literature,
nanostructures
based
on
cluster
arrangements
known
as
"plasmonic
molecules"
(PMs)
have
shown
several
interesting
properties
represent
potential
candidates
implement
different
types
opto-plasmonic
applications.
this
paper,
we
examine
fractal
PM
(FPM),
analyzing
its
by
numerical
simulations
finite
element
method
(FEM).
Next,
periodic
FPM
two
configurations
were
fabricated
an
electron
beam
lithography
(EBL)
process,
their
features
experimentally
characterized.
Our
are
good
agreement
experimental
results.
study
highlights
noticeable
analyzed
PM,
such
multi-resonant
anisotropic
properties,
which
can
be
exploited
design
devices
customized
characteristics
also
compatible
multiple
sensing
We
tested
performance
our
for
surface-enhanced
Raman
spectroscopy
(SERS)
sensing,
realizing
functionalized
system
specific
detection
SARS-CoV-2.
concentrations
virus,
obtaining
limit
(LOD)
88
PFU/mL,
lower
than
that
commercial
rapid
kits.
results
demonstrate
nanopatterns
promising
develop
integrable
sensitive
SERS
portable
point-of-care
(POC)
platform.
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(5), P. 2596 - 2604
Published: April 29, 2024
Cancer
stands
as
a
prominent
global
cause
of
mortality,
necessitating
early
detection
to
augment
survival
rates
and
alleviate
economic
burdens
on
healthcare
systems.
In
particular,
prostate
cancer
(PCa),
impacting
1.41
million
men
globally
in
2020,
accentuates
the
demand
for
sensitive
cost-effective
methods
beyond
traditional
prostate-specific
antigen
(PSA)
testing.
While
clinical
techniques
exhibit
limitations,
biosensors
emerge
compact,
user-friendly
alternatives
laboratory
approaches.
However,
existing
predominantly
concentrate
PSA
detection,
prompting
necessity
advancing
toward
multiplex
sensing
platforms.
This
study
introduces
compact
opto-microfluidic
sensor
featuring
substrate
gold
nanospikes,
fabricated
via
electrodeposition,
enhanced
sensitivity.
Embedded
within
microfluidic
chip,
this
nanomaterial
enables
precise
concurrent
measurement
PSA,
alongside
two
complementary
PCa
biomarkers,
matrix
metalloproteinase-2
(MMP-2)
anti-α-methylacyl-CoA
racemase
(anti-AMACR)
diluted
human
plasma,
offering
comprehensive
approach
analysis.
Taking
advantage
localized
surface
plasmon
resonance
principle,
biosensor
offers
robustness
sensitivity
real
sample
analysis
without
need
labeling
agents.
With
limit
at
0.22,
0.37,
0.18
ng/mL
MMP-2,
anti-AMACR,
respectively,
biosensing
platform
holds
promise
point-of-care
analysis,
underscoring
its
potential
impact
medical
diagnostics.
Lab on a Chip,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
synergy
between
nanoplasmonic
and
microfluidics
opens
a
wealth
of
possibilities
that
span
through
several
research
fields
areas
applications,
ranging
from
analytical
chemistry
to
modern
optofluidic
devices.
Sensors & Diagnostics,
Journal Year:
2024,
Volume and Issue:
3(5), P. 850 - 862
Published: Jan. 1, 2024
Plasmonic
sensors
are
candidates
for
numerous
clinical
applications,
but
few
examples
demonstrate
their
performance
on
large
sample
cohorts,
a
necessary
step
translation.
