Metal-organic frameworks (MOFs) and MOF composites based biosensors

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216102 - 216102

Published: Aug. 8, 2024

Language: Английский

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A Controlled Release Aptasensor Utilizing AIE-Active MOFs as High-Efficiency ECL Nanoprobe for the Sensitive Detection of Adenosine Triphosphate

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(5), P. 2100 - 2106

Published: Jan. 23, 2024

Improving the sensitivity in electrochemiluminescence (ECL) detection systems necessitates integration of robust ECL luminophores and efficient signal transduction. In this study, we report a novel nanoprobe (Zr-MOF) that exhibits strong stable emission by incorporating aggregation-induced ligands into Zr-based metal–organic frameworks (MOFs). Meanwhile, designed high-performance modulator through implementation well-designed controlled release system with self-on/off function. ZnS quantum dots (QDs) encapsulated within cavities aminated mesoporous silica nanoparticles (NH2–SiO2) serve as quenchers, while adenosine triphosphate (ATP) aptamers adsorbed on surface NH2–SiO2 electrostatic interaction act "gatekeepers." Based target-triggered resonance energy transfer between Zr-MOF QDs, establish coreactant-free aptasensor for sensitive ATP, achieving an impressive low limit 0.033 nM. This study not only demonstrates successful combination strategies but also opens new avenues developing highly MOFs-based systems.

Language: Английский

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Spatial-Potential-Color-Resolved Bipolar Electrode Electrochemiluminescence Biosensor Using a CuMoOx Electrocatalyst for the Simultaneous Detection and Imaging of Tetracycline and Lincomycin

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(18), P. 7073 - 7081

Published: April 25, 2024

A spatial-potential-color-resolved bipolar electrode electrochemiluminescence biosensor (BPE-ECL) using a CuMoOx electrocatalyst was constructed for the simultaneous detection and imaging of tetracycline (TET) lincomycin (LIN). HOF-101 emitted peacock blue light under positive potential scanning, CdSe quantum dots (QDs) green negative scanning. could catalyze electrochemical reduction H2O2 to greatly increase Faradic current BPE realize ECL signal amplification. In channel 1, CuMoOx-Aptamer II probes were introduced into hole (left groove A) by dual aptamer sandwich method TET. During polarity negative, resulting in catalyzed CuMoOx, enhanced detecting 2, (LIN) adsorbed on MXene driving (DVE) B) hydrogen-bonding metal-chelating interactions. LIN bound with its aptamers, causing fall off. DVE decreased. The QDs reduced LIN. Furthermore, portable mobile phone platform built colorimetric (CL) TET Thus, multiple mode-resolved be realized simultaneously only one scan, which improved accuracy efficiency. This study opened new technology BPE-ECL sensor application is expected shine microchips point-of-care testing (POCT).

Language: Английский

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Dual-channel molecularly imprinted sensor based on dual-potential electrochemiluminescence of Zn-MOFs for double detection of trace chloramphenicol

Food Chemistry, Journal Year: 2023, Volume and Issue: 413, P. 135627 - 135627

Published: Feb. 3, 2023

Language: Английский

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Electrostatic Interaction-Induced Aggregation-Induced Emission-Type AgAu Bimetallic Nanoclusters as a Highly Efficient Electrochemiluminescence Emitter for Ultrasensitive Detection of Glial Fibrillary Acidic Protein

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(6), P. 3452 - 3459

Published: Jan. 31, 2023

Herein, the aggregation-induced emission (AIE)-type carboxymethyl chitosan (CMCS)@6-aza-2-thiothymine (ATT) templated AgAu bimetallic nanoclusters (CMCS@ATT-AgAu BMNCs) with superior electrochemiluminescence (ECL) were first synthesized to construct a biosensor for ultrasensitive detection of glial fibrillary acidic protein (GFAP). Impressively, unlike traditional AIE-type (BMNCs) obtained by complicated multi-step synthesis, CMCS@ATT-AgAu BMNCs prepared electrostatic interaction between negatively charged ATT and positively CMCS, in which molecule was served as capping reducing agent bimetal ions. In addition, rapidly moving cholesterol labeled DNA walker constructed move freely on lipid bilayer increase its efficiency, well-regulated intelligently designed further improve walking efficiency rapid GFAP limit (LOD) low 73 ag/mL. This strategy proposed an avenue synthesize highly efficient BMNCs-based ECL emitters, have great potential biosensing early diagnosis diseases.

Language: Английский

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A spatial-potential-resolved electrochemiluminescence biosensor for simultaneous detection of BRCA1 and BRCA2 based on a novel self-luminescent metal–organic framework

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 476, P. 146799 - 146799

Published: Oct. 20, 2023

Language: Английский

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Potential-Resolved Ratiometric Aptasensor for Sensitive Acetamiprid Analysis Based on Coreactant-free Electrochemiluminescence Luminophores of Gd-MOF and “Light Switch” Molecule of [Ru(bpy)₂dppz]²⁺

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(12), P. 5022 - 5028

Published: March 12, 2024

For conventional potential-resolved ratiometric electrochemiluminescence (ECL) systems, the introduction of multiplex coreactants is imperative. However, undesirable interactions between different inevitably affect analytical accuracy and sensitivity. Herein, through coordination aggregation-induced emission ligands with gadolinium cations, self-luminescent metal–organic framework (Gd-MOF) prepared serves as a novel coreactant-free anodic ECL emitter. By intercalation [Ru(bpy)2dppz]2+ light switch effect into DNA duplex, one high-efficiency cathodic probe obtained using K2S2O8 coreactant. In presence acetamiprid, strong affinity target its aptamer induces release [Ru(bpy)2dppz]2+, resulting in decreasing cathode signal an increasing anode owing to resonance energy transfer from Gd-MOF [Ru(bpy)2dppz]2+. this way, efficient dual-signal aptasensor constructed for analysis exhibiting remarkably low detection limit 0.033 pM. Strikingly, by only exogenous coreactant, cross interference multiple can be eliminated, thus improving accuracy. The developed high-performance sensing platform successfully applied monitor residual level acetamiprid real samples, demonstrating potential application field food security.

Language: Английский

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Strong cathode electroluminescence biosensor based on CeO2 functionalized PCN-222@Ag NPs for sensitive detection of p-Tau-181 protein

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 665, P. 144 - 151

Published: March 20, 2024

Language: Английский

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High electrochemical active Au-NP/2D zinc-metal organic frameworks heterostructure-based ECL sensor for the miRNA-522 detection in triple negative breast cancer

Talanta, Journal Year: 2023, Volume and Issue: 265, P. 124875 - 124875

Published: June 28, 2023

Language: Английский

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Zero-Background Dual-Mode Closed Bipolar Electrode Electrochemiluminescence Biosensor Based on ZnCoN-C Potential Regulation for Ultrasensitive Detection of Ochratoxin A

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

In this work, the relationship between electrochemiluminescence (ECL) signal and driving voltage was first studied by self-made reduced oxidized closed bipolar electrodes (CBPEs). It found that when large enough, maximum ECL signals for two kinds of CBPEs were same but their required drive voltages different. Zinc cobalt nitrogen doped carbon material (ZnCoN-C) had an outstanding electric double layer (EDL) property conductivity. Therefore, it could significantly reduce CBPE systems, reaching Ru(bpy)32+. Interestingly, ZnCoN-C modified electrode reached signal, bare zero. As a proof-of-concept application, zero-background dual-mode CBPE-ECL biosensor constructed ultrasensitive detection ochratoxin A (OTA) in beer. Considering beer samples contained number reducing substances, system selected to build biosensor. Furthermore, convenient imaging platform using smartphone built OTA. This work used unique EDL regulate time; thus, novel sensor constructed. Further, provided deeper understanding opened new door detection.

Language: Английский

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