Microporous and Mesoporous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 113560 - 113560
Published: Feb. 1, 2025
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 529, P. 216458 - 216458
Published: Jan. 22, 2025
Language: Английский
Citations
2
Langmuir, Journal Year: 2024, Volume and Issue: 40(43), P. 22477 - 22503
Published: Oct. 17, 2024
The porous materials known as metal-organic frameworks (MOFs) stand out for their enormous surface area, adaptable pore size and shape, structural variety. These characteristics make them well-suited various applications, especially in healthcare. This review thoroughly summarizes recent studies on the use of MOFs drug delivery, biosensing, therapeutics. may encapsulate medications, target certain cells or tissues, regulate release over time. Additionally, have potential to be used biosensing allowing selective detection chemical biological substances. MOFs' optical electrical modified biosensors that track physiological data. show targeted delivery regulated therapeutic substances cancer treatment. In addition, they work potent antibacterial agents, providing a less dangerous option than traditional antibiotics increase antibiotic resistance. For practical further research is required well more consideration problems with toxicity biocompatibility. addition addressing difficulties promising possibilities this study intends provide insights into healthcare Despite several essential reviews it was necessary look most therapy combined concept.
Language: Английский
Citations
11
Environmental Research, Journal Year: 2025, Volume and Issue: 268, P. 120753 - 120753
Published: Jan. 4, 2025
Language: Английский
Citations
1
Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141321 - 141321
Published: Jan. 1, 2025
Language: Английский
Citations
1
Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(3)
Published: Jan. 27, 2025
Photodynamic therapy (PDT) is a noninvasive cancer treatment that works by using light to stimulate the production of excessive cytotoxic reactive oxygen species (ROS), which effectively eliminates tumor cells. However, therapeutic effects PDT are often limited hypoxia, prevents effective cell elimination. The (O2) consumption during can further exacerbate leading post-treatment adverse events. This review aims explore potential cuproptosis, recently discovered copper-dependent form programmed death, enhance anticancer PDT. Cuproptosis highly dependent on mitochondrial respiration, specifically tricarboxylic acid (TCA) cycle, and increase O2 ROS levels or decrease glutathione (GSH) levels, thereby improving outcomes. discusses latest research advancements in field, detailing mechanisms regulate cuproptosis It also explores how nanoparticle (NP)-based strategies be used exploit synergistic between article examines prospects activity guided nanodelivery systems, could overcome challenges associated with hypoxia treatment. combination PDT, facilitated NP-based delivery presents promising approach effectiveness therapy. concludes discussing future directions for this therapy, highlighting need investigation into optimization improve outcomes
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160371 - 160371
Published: Feb. 1, 2025
Language: Английский
Citations
1
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 7, 2025
Rapid and accurate detection plays a critical role in improving the survival prognosis of patients with cardiovascular disease, but traditional methods are far from ideal for those suspected conditions. Metabolite analysis based on nanomatrix-assisted laser desorption/ionization mass spectrometry (NMALDI-MS) is considered to be promising technique disease diagnosis. However, performance core nanomatrixes has limited its clinical application. In this study, we constructed 3D flower-shaped cages controllable structured metal-organic frameworks iron oxide nanoparticles low thermal conductivity significant photothermal effects. The elongation incident light path through multilayer reflection significantly enhances effective absorption area nanomatrixes. Concurrently, alternating layered structure confines energy, reducing losses. Moreover, increases affinity sites, expanding coverage. This approach effectively ionization desorption efficiency during LDI process. We applied technology analyze serum metabolomes myocardial infarction, heart failure, failure combined achieving cost-effective, high-throughput, highly accurate, user-friendly diseases. Subsequently, deep detected fingerprints via artificial intelligence models screens potential metabolic biomarkers, providing new paradigm diagnosis
Language: Английский
Citations
1
ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 3546 - 3557
Published: Feb. 12, 2025
Language: Английский
Citations
1
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Detecting pathogenic bacteria is crucial for controlling infectious diseases, safeguarding public health, and ensuring food water safety. The integration of metal-organic frameworks (MOFs) with aptamers offers a promising approach to enhance bacterial detection. Aptamers provide high specificity target recognition, while MOFs contribute tunable porous structures stability, forming robust biosensors. This synergy improves sensitivity, selectivity, versatility, enabling real-time quantitative Applications span safety, environmental monitoring, point-of-care diagnostics. review highlights the significance aptamer@MOF biosensors, discussing various detection techniques aptamer immobilization methods. It also addresses challenges like enhancing improving minimizing interference, advancing scalability real-world applications. Additionally, limitations such as need miniaturization, multimode detection, multiplex analysis are highlighted. Future directions focus on optimizing design expanding applications overcome these limitations. versatility potential biosensors underscore their promise high-performance platforms in diverse fields.
Language: Английский
Citations
1
Sensors, Journal Year: 2024, Volume and Issue: 24(20), P. 6701 - 6701
Published: Oct. 18, 2024
This work reported gold nanoparticles (AuNPs)-based colorimetric immunoassay with the Cu-based metal–organic framework (MOF) to load pyrroloquinoline quinone (PQQ) for catalytic oxidation of cysteine. In this method, both Cu2+ and PQQ in MOF could promote inducer cysteine by redox cycling, thus limiting cysteine-induced aggregation AuNPs achieving dual signal amplification. Specifically, recombinant carcinoembryonic antigen (CEA) targets were anchored on through metal coordination interactions between hexahistidine (His6) tag CEA unsaturated sites MOF. The CEA/PQQ-loaded be captured antibody-coated ELISA plate catalyze However, once target samples bound antibody immobilized surface, attachment would limited. Cysteine remaining solution trigger cause a color change from red blue. concentration was positively related AuNPs. signal-on competitive plasmonic exhibited low detection limit linear range 0.01–1 ng/mL. Note that most proteins commercial kits are His6 N- or C-terminal, so provide sensitive platform biomarkers.
Language: Английский
Citations
4