Current trends in biosensors for biotoxins (mycotoxins, marine toxins, and bacterial food toxins):principles, application, and perspective

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 165, P. 117144 - 117144

Published: June 17, 2023

Language: Английский

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Near-Infrared Responsive Ag@Au Nanoplates with Exceptional Stability for Highly Sensitive Colorimetric and Photothermal Dual-Mode Lateral Flow Immunoassay

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 5, 2024

Lateral flow immunoassay (LFIA) has played a vital role in point-of-care (POC) testing on account of its simplicity, rapidity, and low cost. However, the sensitivity difficulty quantitation limit further development. Sensitive markers with new detection modes are being developed to dramatically improve LFIA's performance. Herein, ligand-complex approach was proposed uniformly coat thin layer Au onto Ag triangular nanoplates (Ag TNPs) without etching cores, which not only retain unique optical properties from TNPs but also acquire surface stability biocompatibility gold. The localized plasmon resonance absorption these Ag@Au could be finely adjusted visible (550 nm) second near-infrared region (NIR-II) (1100 nm), even longer, by simply adjusting ratio between edge length thickness. Utilizing as for LFIA, highly sensitive colorimetric photothermal dual-mode SARS-CoV-2 nucleocapsid protein achieved very background. showed an exceedingly high conversion efficiency 61.4% (ca. 2 times higher than that nanorods), endowing LFIA method (40 pg/mL), 25-fold lower results. generality verified accurate analysis cardiac troponin I (cTnI). This is robust, reproducible, specific been successfully applied SARS-COV-2 35 clinical samples satisfactory results, demonstrating potential POC applications.

Language: Английский

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Efficient Photothermal Sensor Based on Coral‐Like Hollow Gold Nanospheres for the Sensitive Detection of Sulfonamides

Small, Journal Year: 2024, Volume and Issue: 20(28)

Published: Feb. 19, 2024

Abstract Gold nanoparticles (AuNPs), universally regarded as colorimetric signal reporters, are widely employed in lateral flow immunoassays (LFIAs). However, it is difficult for AuNPs‐LFIA to achieve a wide range and sensitive detection. Herein, novel coral‐like hollow gold nanospheres (CHGNPs) synthesized. The growth of can be regulated obtain multibranched construction. obtained CHGNPs possess intense broadband absorption across the visible near‐infrared region, exhibiting high molar extinction coefficient 14.65 × 10 11 M −1 cm photothermal conversion efficiency 79.75%. Thus, photothermal/colorimetric dual‐readout LFIA developed based on (CHGNPs‐PT‐LFIA CHGNPs‐CM‐LFIA) effectively improve detection sensitivity broaden regard sulfonamides (SAs). limits CHGNPs‐PT‐LFIA CHGNPs‐CM‐LFIA reached 1.9 2.8 pg mL quantitative sulfaquinoxaline, respectively, which 6.3‐fold 4.3‐fold lower than that AuNPs‐LFIA. Meanwhile, broadened three orders magnitude, ranged from 2.5 5000 . synthesized have been proven effective improving performance provide potential option construction sensing platforms.

Language: Английский

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IR-Driven Multisignal Conditioning for Multiplex Detection: Thermal-Responsive Triple DNA-Mediated Reconfigurable Photoelectrochemical/Photothermal Dual-Mode Strategy

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Superior to traditional multiplex photoelectrochemical (PEC) sensors, integrated multitarget assay on a single reconstructive electrode interface is promising in real-time detection through eliminating the need of specialized instrumentation and cumbersome interfacial modifications. Current reconstruction approaches including pH modulation bioenzyme cleavage involve biohazardous time-consuming operations, which cannot meet demand for rapid, eco-friendly, portable detection, are detrimental development PEC sensors toward portability. Herein, we report pioneer work IR-driven "four-to-one" multisignal conditioning facile reconfigure via photoelectrochemical/photothermal dual mode. The copper sulfide quantum dot (CuS QD) with excellent properties photothermal effect first labeled DNA S2. Once CuS QD-S2 complementarily pairs S3 photocathode surface, thermal-responsive triple formed, photocurrent dual-mode signals one target produced. Upon dissociation by IR irradiation, reconfigured self-calibrating another target. feasibility sensor confirmed detecting coexistent antibiotics kanamycin (KANA) neomycin (NEO) complex real samples. low-loss reconfiguration rapid highlight broad prospect fields environment, medicine, food safety.

Language: Английский

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The “umbrella of tolerance”: Nanobodies-armed photothermal lateral flow immunoassay for the detection of staphylococcal enterotoxin B

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 470, P. 144273 - 144273

Published: June 22, 2023

Language: Английский

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Performance enhancement of the lateral flow immunoassay by use of composite nanoparticles as signal labels

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 170, P. 117441 - 117441

Published: Nov. 19, 2023

Language: Английский

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Responsive metal–organic framework nanocarrier delivery system: An effective solution against bacterial infection

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215431 - 215431

Published: Sept. 4, 2023

Language: Английский

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A Programmable Microfluidic Paper-Based Analytical Device for Simultaneous Colorimetric and Photothermal Visual Sensing of Multiple Enzyme Activities

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(29), P. 12181 - 12188

Published: July 8, 2024

New strategies for the simultaneous and portable detection of multiple enzyme activities are highly desirable clinical diagnosis home care. However, methods developed thus far generally suffer from high costs, cumbersome procedures, heavy reliance on large-scale instruments. To satisfy actual requirements rapid, accurate, on-site activities, we report herein a smartphone-assisted programmable microfluidic paper-based analytical device (μPAD) that utilizes colorimetric photothermal signals simultaneous, visual quantitative alkaline phosphatase (ALP) butyrylcholinesterase (BChE). Specifically, operation this μPAD sensing platform is based two sequential steps. Cobalt-doped mesoporous cerium oxide (Co-m-CeO

Language: Английский

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Dual-Readout Ultrasensitive Lateral Flow Immunosensing of Salmonella typhimurium in Dairy Products by Doping Engineering-Powered Nanoheterostructure with Enhanced Photothermal Performance

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(8), P. 4405 - 4414

Published: Feb. 15, 2024

The photothermal lateral flow immunoassay (LFIA) is of great significance to suitable for on-site semiquantitative detection, which has the upper hand in further constructing detection methods low-concentration targets. Herein, we presented a doping engineering-powered nanoheterostructure with an enhanced performance strategy, employing bimetallic nanocuboid Pt3Sn (PSNCs) as proof concept. With help finite element simulation analysis, contrast direct temperature experiment, and evaluation conversion efficiency (η), distinguished enthusiastic feedback PSNCs proved. Based on steady bright black colorimetric superior performance, were employed construct ultrasensitive model LIFA detecting Salmonella typhimurium (S. typhimurium), achieved double-signal limit reached 103 cfu mL–1 (colorimetric mode) 102 (photothermal mode), 100 times higher than that traditional colloidal gold method. In addition, method was effective targets dairy samples only through simple dilution treatment, completed within 15 min. Meanwhile, this dual-signal LFIA demonstrated sensitive S. due excellent signal significant provides broad spectrum future foodborne pathogens.

Language: Английский

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Photothermal detection of food hazards using temperature as an indicator: Principles, sensor developments and applications

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 146, P. 104393 - 104393

Published: Feb. 27, 2024

Photothermal sensing, due to its high resolution and spatial controllability, has gained significant attention in optical imaging for applications such as disease treatment diagnosis, environmental monitoring, etc. It effectively overcome the drawbacks of traditional sensors, susceptibility interference, cost, lack portability, strong dependency on operational procedures. conversion-based light-responsive temperature change sensors have been proven break limitations, serving an alternative strategy more potential applications, particularly detection hazardous substances food. In current review, principles generation photothermal materials corresponding representative are inducted modulation signals response-dependent principle rapid discussed. The practical food hazard outlook challenges faced also presented review. Various doped modified shown enable quantitative hazards through different signal mechanisms well relying non-specific, molecular biological immunological responses. is hoped that review can provide researchers with reference sources further developments effective sensitive safety assurance industry.

Language: Английский

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