Vertical Graphene-Based Printed Electrochemical Biosensor for Simultaneous Detection of Four Alzheimer’s Disease Blood Biomarkers

Biosensors, Journal Year: 2023, Volume and Issue: 13(8), P. 758 - 758

Published: July 25, 2023

Early detection and timely intervention play a vital role in the effective management of Alzheimer's disease. Currently, diagnostic accuracy for disease based on single blood biomarker is relatively low, combined use multiple biomarkers can greatly improve accuracy. Herein, we report printed electrochemical biosensor vertical graphene (VG) modified with gold nanoparticles (VG@nanoAu) simultaneous four biomarkers. The electrode array was constructed by laser etching inkjet printing. Then were onto working surface via electrodeposition to further sensitivity sensor. In addition, entire sensing system incorporates an micro-workstation smartphone. customized electro-chemical control chips, enabling sensor simultaneously analyze Consequently, exhibits excellent analytical performance due large area, biocompatibility, good conductivity VG@nanoAu. limit Aβ40, Aβ42, T-tau, P-tau181 0.072, 0.089, 0.071, 0.051 pg/mL, respectively, which meets requirements also specificity stability. This work has great value promising prospects early diagnosis using

Language: Английский

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A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer's disease therapy

Bioactive Materials, Journal Year: 2024, Volume and Issue: 42, P. 165 - 177

Published: Aug. 30, 2024

Abnormal hyperphosphorylation of tau protein is a principal pathological hallmark in the onset neurodegenerative disorders, such as Alzheimer's disease (AD), which can be induced by an excess reactive oxygen species (ROS). As antioxidant, hydrogen gas (H

Language: Английский

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Graphene oxide-based fluorescent biosensors for pathogenic bacteria detection: a review

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1337, P. 343428 - 343428

Published: Nov. 17, 2024

Language: Английский

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Integration of PG and NMM as a universal unlabeled, enzyme-free, luminescent-nanomaterial-free and catalysis-free dual-output system for versatile concurrent DNA logic computing and ratiometric fluorescent sensing

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159278 - 159278

Published: Jan. 1, 2025

Language: Английский

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Surface-enhanced spectroscopy technology based on metamaterials

Microsystems & Nanoengineering, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 3, 2025

Abstract Surface-enhanced spectroscopy technology based on metamaterials has flourished in recent years, and the use of artificially designed subwavelength structures can effectively regulate light waves electromagnetic fields, making it a valuable platform for sensing applications. With continuous improvement theory, several effective universal modes have gradually formed, including localized surface plasmon resonance (LSPR), Mie resonance, bound states continuum (BIC), Fano resonance. This review begins by summarizing these core mechanisms, followed comprehensive overview six main surface-enhanced techniques across spectrum: fluorescence (SEF), Raman scattering (SERS), infrared absorption (SEIRA), terahertz (THz) sensing, refractive index (RI) chiral sensing. These cover wide spectral range address various optical characteristics, enabling detection molecular fingerprints, structural chirality, changes. Additionally, this summarized combined different enhanced spectra, integration with other advanced technologies, status miniaturized metamaterial systems. Finally, we assess current challenges future directions. Looking to future, anticipate that metamaterial-based will play transformative role real-time, on-site scientific, environmental, biomedical fields.

Language: Английский

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Sensing multiplex microRNAs using dual-functional fork-type-track DNA nanomachine on optical fiber

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 413, P. 135873 - 135873

Published: April 24, 2024

Language: Английский

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High AIECL performance of tetraphenylethene derivatives originated from the linear increasing of benzene ring and solvent regulation for sensitive measurement of melatonin

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 237, P. 115544 - 115544

Published: July 27, 2023

Language: Английский

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Aggregation-Induced Emission-Based Chemiluminescence Systems in Biochemical Analysis and Disease Theranostics

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 983 - 983

Published: Feb. 23, 2024

Chemiluminescence (CL) is of great significance in biochemical analysis and imaging due to its high sensitivity lack need for external excitation. In this review, we summarized the recent progress AIE-based CL systems, including their working mechanisms applications analysis, bioimaging, disease diagnosis treatment. ion molecular detection, shows selectivity sensitivity, especially detection dynamic reactive oxygen species (ROS). Further, integrated NIR-CL single-molecule system nanostructural platform harnessing resonance energy transfer (CRET) have remarkable advantages long-term with superior capability penetrating deep tissue depth signal-to-noise ratio, are promising vivo image-guided therapy. Finally, shortcomings existing AIE-CL provided our perspective on possible ways develop more powerful systems future. It can be highly expected that these promoted will play bigger roles theranostics.

Language: Английский

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2D Material Sensors with Light Excitation

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(48)

Published: Oct. 10, 2024

Abstract 2D materials are highly regarded for their exceptional sensing application prospects, stemming from distinctive atomic layer structure and exceptionally sensitive surfaces. Over the past decade, numerous high‐performance material sensors extensively developed; however, challenges related to sensitivity, selectivity, stability continue impede industrial advancement. The interaction between light has introduced unique properties, including absorption emission characteristics, photoelectric effects, nonlinear optical surface‐enhanced Raman scattering, response enhancement. Consequently, exciting adjusting electronic carrier concentration of through with specific wavelength ranges is an effective strategy enhancing performance. This yielded remarkable breakthroughs in applications such as photodetectors, semiconductor gas sensors, fiber optic sensors. Moreover, it demonstrates extraordinary potential emerging image flexible electronics, biomedical However, mechanism, device design, under excitation remain unclear. perspective endeavors elucidate intrinsic photophysical mechanisms light‐excited target analytes. Furthermore, aims explain evolutionary pattern provide novel insights inspiration advance this burgeoning field.

Language: Английский

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Tau‑targeting multifunctional nanocomposite based on tannic acid-metal for near-infrared fluorescence/magnetic resonance bimodal imaging-guided combinational therapy in Alzheimer's disease

Theranostics, Journal Year: 2024, Volume and Issue: 14(16), P. 6218 - 6235

Published: Jan. 1, 2024

Alzheimer's disease (AD) is hallmarked by amyloid-β (Aβ) plaques and hyperphosphorylated tau (p-tau) neurofibrillary tangles. While Aβ-centric therapies have shown promise, the complex pathology of AD requires a multifaceted therapeutic approach. The weak association between Aβ levels cognitive decline highlights need for alternative theranostic strategies. Currently, oxidative stress hyperphosphorylation are now recognized as critical pathological events in AD. Thus, that concurrently attenuate damage inhibit hold great potential treatment.

Language: Английский

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