International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 288, P. 138636 - 138636
Published: Dec. 12, 2024
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 20, 2025
The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes
Language: Английский
Citations
3
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(34)
Published: April 13, 2024
Abstract The peroxidase (POD)‐mimic nanozymes can be a potential tool for point‐of‐care (POC) diseases diagnosis. However, the complex sample matrix and unspecific multiple‐enzyme activities of nanozyme generate false background signal decrease diagnostic accuracy. Here, magnetic POD‐specific covalent organic framework (COF) confined osmium (Os) nanoclusterzyme Fe 3 O 4 @COF@Os is developed biomarkers biosensing. First, found that catalytic activity specificity regulated by deoxidizers functional groups COF ligands. By using ascorbic acid as deoxidizer F ligands, displayed superior negligible oxidase (OXD) catalase (CAT) mimic activity. Therefore, separate analyze targets in bio‐matrix without interference. For application, based lateral flow assay established serum cancer biomarker prostate‐specific antigen, detection limit 3.83 pg mL −1 . clinical prostatic samples, accuracy 100% with correlation coefficient 0.998 commercial ELISA kit. chronic disease sensing, salivary glucose quantified low 0.1 µ m , interference favorable recyclability. This specific offer promising pretreatment‐free POC strategy rapid accurate
Language: Английский
Citations
16
Electrochimica Acta, Journal Year: 2024, Volume and Issue: 499, P. 144685 - 144685
Published: Sept. 1, 2024
Language: Английский
Citations
13
Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112363 - 112363
Published: Dec. 1, 2024
Language: Английский
Citations
12
Small, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Abstract Mimicking the structure of natural enzyme active sites offers a promising strategy for rational design nanozymes. However, this biomimetic approach predominantly focuses on replicating configuration metal center in enzymes, often overlooking critical influence catalytic site's microenvironment. Here, inspired by and coordination microenvironment organophosphorus hydrolase (OPH), Ce 2 O CN /NC, novel cerium‐based nanozyme is first reported to mimic OPH. In species serve as sites, while adjacent N site ([N═C═N] 2− ) functions general base, mimicking histidine enzymes facilitate hydrolysis process. Using paraoxon model target, /NC demonstrates rapid dephosphorylation phosphotriester across wide range temperatures pH values, significantly outperforming OPH CeO nanoparticles. The systematic experiments theoretical calculations reveal underlying mechanisms responsible enhanced OPH‐mimicking performance. Capitalizing its phosphatase‐like activity, successfully employed develop colorimetric biosensor selective detection pesticides. This study holds great promise developing efficient nanozymes broadens Ce‐based
Language: Английский
Citations
1
Nano Letters, Journal Year: 2024, Volume and Issue: 24(31), P. 9635 - 9642
Published: July 30, 2024
Natural phosphatases featuring paired metal sites inspire various advanced nanozymes with phosphatase-like activity as alternatives in practical applications. Numerous efforts to create point defects show limited site pairs, further resulting insufficient activity. However, it remains a grand challenge accurately engineer abundant pairs nanozymes. Herein, we report grain-boundary-rich ceria metallene nanozyme (GB-CeO2) Grain boundaries acting the line or interfacial can effectively increase content of Ce4+/Ce3+ 72.28%, achieving 49.28-fold enhancement Furthermore, grain optimize band structure assist photoelectron transfer under irradiation, which increases 88.96% and finally realizes 114.39-fold enhanced over that CeO2 without irradiation. Given different inhibition effects pesticides on catalysts GB-CeO2 was successfully applied recognize mixed toxic pesticides.
Language: Английский
Citations
4
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 21, 2024
Since the discovery of first peroxidase nanozyme (Fe
Language: Английский
Citations
3
Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(39)
Published: July 9, 2024
Abstract Since the discovery of first peroxidase nanozyme (Fe 3 O 4 ), numerous nanomaterials have been reported to exhibit intrinsic enzyme‐like activity toward inorganic oxygen species, such as H 2 , oxygen, and − . However, exploration nanozymes targeting organic compounds holds transformative potential in realm industrial synthesis. This review provides a comprehensive overview diverse types that catalyze reactions involving substrates discusses their catalytic mechanisms, structure‐activity relationships, methodological paradigms for discovering new nanozymes. Additionally, we propose forward‐looking perspective on designing formulations mimic subcellular organelles, chloroplasts, termed “nano‐organelles”. Finally, analyze challenges encountered synthesis, characterization, nano‐organelle construction applications while suggesting directions overcome these obstacles enhance research future. Through this review, our goal is inspire further efforts advancements field nanozymes, fostering insights opportunities chemical
Language: Английский
Citations
3
Published: Jan. 1, 2025
Language: Английский
Citations
0
Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Language: Английский
Citations
0