Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(2), P. 170 - 170
Published: Jan. 12, 2024
Analytical
methods
for
the
early
detection
of
neurodegenerative
biomarker
Parkinson’s
disease
(PD),
α-synuclein,
are
time-consuming
and
invasive,
require
skilled
personnel
sophisticated
expensive
equipment.
Thus,
a
pain-free,
prompt
simple
α-synuclein
biosensor
in
plasma
is
highly
demanded.
In
this
paper,
an
electrochemical
based
on
hierarchical
polyglutamic
acid/ZnO
nanowires
decorated
by
gold
nanoparticles,
assembled
as
nanostars
(NSs),
determination
human
proposed.
ZnO
NSs
were
prepared
chemical
bath
deposition
(CBD)
with
electrodeposited
Au
nanoparticles
(Au
NPs).
Then,
electro-polymerized
glutamic
acid
was
grown
functionalized
anti-α-synuclein.
A
synergistic
enhancement
electrode
sensitivity
observed
when
NPs
embedded
into
NSs.
The
analytical
performance
evaluated
cyclic
voltammetry
(CV)
impedance
spectroscopy
(EIS),
using
Fe(II)(CN)64−/Fe(III)(CN)63−
probe.
charge
transfer
resistance
after
recognition
found
to
be
linear,
concentration
range
0.5
pg·mL−1
10
pg·mL−1,
limit
0.08
good
reproducibility
(5%
variation)
stability
(90%).
also
shown
reliably
discriminate
between
healthy
PD
plasma.
These
results
suggest
that
proposed
provides
rapid,
quantitative
high-sensitivity
result
content
plasma,
represents
feasible
tool
capable
accelerating
non-invasive
identification
disease.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 916 - 916
Published: March 11, 2023
Alzheimer’s
disease
(AD),
as
a
neurodegenerative
disorder,
usually
develops
slowly
but
gradually
worsens.
It
accounts
for
approximately
70%
of
dementia
cases
worldwide,
and
is
recognized
by
WHO
public
health
priority.
Being
multifactorial
disease,
the
origins
AD
are
not
satisfactorily
understood.
Despite
huge
medical
expenditures
attempts
to
discover
new
pharmaceuticals
or
nanomedicines
in
recent
years,
there
no
cure
many
successful
treatments
available.
The
current
review
supports
introspection
on
latest
scientific
results
from
specialized
literature
regarding
molecular
cellular
mechanisms
brain
photobiomodulation,
complementary
method
with
implications
AD.
State-of-the-art
pharmaceutical
formulations,
development
nanoscale
materials,
bionanoformulations
applications
perspectives
highlighted.
Another
goal
this
was
speed
transition
completely
paradigms
multi-target
management
AD,
facilitate
remodeling
through
therapeutic
models
high-tech
light
lasers
integrative
nanomedicine
future.
In
conclusion,
insights
interdisciplinary
approach,
including
photobiomodulation
(PBM)
applied
human
clinical
trials,
combined
drug
delivery
systems
easily
overcome
protective
barriers,
could
open
avenues
rejuvenate
our
central
nervous
system,
most
fascinating
complex
organ.
Picosecond
transcranial
laser
stimulation
be
successfully
used
cross
blood-brain
barrier
together
nanotechnologies,
therapy.
Original,
smart
targeted
multifunctional
solutions
nanodrugs
may
soon
developed
treat
Diagnostics,
Journal Year:
2023,
Volume and Issue:
13(5), P. 916 - 916
Published: Feb. 28, 2023
Personalized
point-of-care
testing
(POCT)
devices,
such
as
wearable
sensors,
enable
quick
access
to
health
monitoring
without
the
use
of
complex
instruments.
Wearable
sensors
are
gaining
popularity
owing
their
ability
offer
regular
and
continuous
physiological
data
by
dynamic,
non-invasive
assessments
biomarkers
in
biofluids
tear,
sweat,
interstitial
fluid
saliva.
Current
advancements
have
concentrated
on
development
optical
electrochemical
well
advances
measurements
metabolites,
hormones
microbes.
For
enhanced
wearability
ease
operation,
microfluidic
sampling,
multiple
sensing,
portable
systems
been
incorporated
with
materials
that
flexible.
Although
show
promise
improved
dependability,
they
still
require
more
knowledge
about
interaction
between
target
sample
concentrations
blood
biofluids.
In
this
review,
we
described
importance
for
POCT,
design
types
these
devices.
Following
which,
emphasize
current
breakthroughs
application
realm
integrated
POCT
Lastly,
discuss
present
obstacles
forthcoming
potentials
including
Internet
Things
(IoT)
offering
self-healthcare
using
POCT.
Current Research in Biotechnology,
Journal Year:
2023,
Volume and Issue:
5, P. 100129 - 100129
Published: Jan. 1, 2023
The
natural
barrier
that
separates
us
from
our
surroundings
is
skin.
It
enables
to
experience
a
range
of
forms
sensations,
temperature
variations,
and
different
levels
touch
pressure.
Because
human
skin
so
instinctive,
it's
simple
overlook
the
intricacy
body's
primary
sensory
organ.
Our
contains
variety
diverse,
highly
specialized
sense
receptors
enable
it
perceive
functions
efficiently
securely
with
great
precision.
These
receptors,
by
making
use
an
integrated
flexible
system,
convert
physical
contact
information
into
electrical
impulses
before
sending
nervous
system
for
further
involved
interpretation.
Electronic
skin,
i.e.,
E-skin
also
referred
as
e-skin
or
synthetic
very
thin
material
made
fusing
electronic
components
elastic,
pliable
substrates
are
efforts
mimicking
potentials
cutting-edge
technology
largely
used
medicinal
purposes,
such
detecting
perceiving
internal
life
sign
processes
in
living
beings,
well
their
unprecedented
monitoring.
To
explore
aspects
health
wellness,
this
article
explores
recent
advancements
technologies,
properties
materials
fabrication,
its
future
potential.