Annals of Neurosciences, Journal Year: 2023, Volume and Issue: 31(2), P. 83 - 85
Published: Nov. 3, 2023
Language: Английский
Neurotherapeutics, Journal Year: 2023, Volume and Issue: 21(1), P. e00292 - e00292
Published: Dec. 19, 2023
Recent advances in understanding the role of mitochondrial dysfunction neurodegenerative diseases have expanded opportunities for neurotherapeutics targeting mitochondria to alleviate symptoms and slow disease progression. In this review, we offer a historical account biology disease. Additionally, summarize current knowledge normal physiology pathogenesis dysfunction, disease, therapeutics recent therapeutic advances, as well future directions function. A focus is placed on reactive oxygen species their disruption telomeres effects epigenome. The etiology progression Alzheimer's amyotrophic lateral sclerosis, Parkinson's Huntington's are discussed depth. Current clinical trials mitochondria-targeting discussed.
Language: Английский
Citations
69
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 9, 2024
Abstract Predicting the blood–brain barrier (BBB) permeability of small-molecule compounds using a novel artificial intelligence platform is necessary for drug discovery. Machine learning and large language model on (AI) tools improve accuracy shorten time new development. The primary goal this research to develop computing models deep architectures capable predicting whether molecules can permeate human (BBB). in silico (computational) vitro (experimental) results were validated by Natural Products Research Laboratories (NPRL) at China Medical University Hospital (CMUH). transformer-based MegaMolBART was used as simplified molecular input line entry system (SMILES) encoder with an XGBoost classifier method check if molecule could cross through BBB. We Morgan or Circular fingerprints apply algorithm set atomic invariants baseline also compare results. BBB assessed three-dimensional (3D) spheroids (human brain microvascular endothelial cells, vascular pericytes, astrocytes). Using multiple databases, final transformer achieved area under receiver operating characteristic curve 0.88 held-out test dataset. Temozolomide (TMZ) 21 randomly selected permeable (Pred scores = 1, indicating BBB-permeable) from NPRL penetrated spheroid cells. No evidence suggests that ferulic acid five BBB-impermeable < 1.29423E−05, which designate pass BBB) cells Our validation experiments indicated prediction permeation accurate. Transformer-based like MegaMolBART, leveraging SMILES representations molecules, show great promise applications These have potential accelerate development targeted treatments disorders central nervous system.
Language: Английский
Citations
15
Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)
Published: May 21, 2024
Abstract Alzheimer’s disease (AD) poses a significant public health problem, affecting millions of people across the world. Despite decades research into therapeutic strategies for AD, effective prevention or treatment this devastating disorder remains elusive. In review, we discuss potential photobiomodulation (PBM) preventing and alleviating AD-associated pathologies, with focus on biological mechanisms underlying therapy. Future directions guidance clinical practice non-invasive non-pharmacological therapy are also highlighted. The available evidence indicates that different paradigms, including transcranial systemic PBM, along recently proposed remote all could be promising AD. PBM exerts diverse effects, such as enhancing mitochondrial function, mitigating neuroinflammation caused by activated glial cells, increasing cerebral perfusion, improving glymphatic drainage, regulating gut microbiome, boosting myokine production, modulating immune system. We suggest may serve powerful intervention
Language: Английский
Citations
8
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 94, P. 102183 - 102183
Published: Jan. 11, 2024
Brain diseases present a significant obstacle to both global health and economic progress, owing their elusive pathogenesis the limited effectiveness of pharmaceutical interventions. Phototherapy has emerged as promising non-invasive therapeutic modality for addressing age-related brain disorders, including stroke, Alzheimer's disease (AD), Parkinson's (PD), among others. This review examines recent progressions in phototherapeutic Firstly, article elucidates various wavelengths visible light that possess capability penetrate skin skull, well pathways stimulation, encompassing eyes, skin, veins, skull. Secondly, it deliberates on molecular mechanisms photosensitive proteins, within context disorders other modulation. Lastly, practical application phototherapy diverse clinical neurological is indicated. Additionally, this presents novel approaches combine pharmacological Moreover, outlines limitations phototherapeutics proposes innovative strategies improve treatment cerebral disorders.
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10946 - 10946
Published: June 30, 2023
The global number of people with Alzheimer’s disease (AD) doubles every 5 years. It has been established that unless an effective treatment for AD is found, the incidence will triple by 2060. However, pharmacological therapies have failed to show effectiveness and safety. Therefore, search alternative methods treating urgent problem in medicine. lymphatic drainage removal system brain (LDRSB) plays important role resistance progression AD. development augmentation LDRSB functions may contribute progress therapy. Photobiomodulation (PBM) considered be a non-pharmacological safe approach Here, we highlight most recent relevant studies PBM We focus on emerging evidence indicates potential benefits during sleep modulation natural activation at nighttime, providing metabolites, including amyloid-β, from brain, leading reduced Our review creates new niche therapy diseases sheds light smart technologies neurodegenerative diseases.
Language: Английский
Citations
13
Deleted Journal, Journal Year: 2024, Volume and Issue: 2(1)
Published: Jan. 1, 2024
Abstract Light therapy techniques, such as photobiomodulation (PBMT), photodynamic (PDT), and laser photoablation, have gained widespread attention become indispensable physiotherapy methods in clinical practice. PBMT involves the application of low‐level laser/LED to modulate function nerve cells, relieve neuroinflammation, promote neurogenesis vascular growth. Recent studies shown that holds promise a complementary or alternative treatment Alzheimer's disease (AD), traumatic brain injury (TBI), major depressive disorder (MDD), etc. However, therapeutic effect is influenced by various factors, patients' condition, structure function, illumination parameters, Therefore, optimized personalized schedules, precise evaluation are crucial success. In this review, we identified recent experimental successes, existing obstacles, future opportunities for diseases. As non‐invasive, side‐effect‐free, highly accessible technique, brings glimmer light neuropsychiatric disorders neuro‐rejuvenation human brains.
Language: Английский
Citations
4
Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by significant cognitive and behavioral impairments. Near-infrared (NIR) light treatment has shown potential in improvement previous studies. However, clinical trials of NIR for AD remain limited. Objective This study investigated the safety effects whole-head 810 nm therapy patients, including long-term efficacy. Methods An open-label pilot on patients was conducted. Nine completed 4-month (810 nm, 100 mW/cm², 30 min/session, 6 sessions weekly). Safety efficacy were evaluated at baseline, months 2 4, 2-month post-treatment. Results After four treatment, mean changes from baseline Mini-Mental State Examination 3.2 ( p = 0.02). Mean Disease Assessment Scale-Cognitive −5.0 0.05), Montreal Cognitive 1.9 0.12). Neuropsychiatric Inventory −4.2 0.47). These benefits sustained two least. With no device-related adverse reported. Conclusions Whole-head safe offers promising patients. To fully confirm its efficacy, durability, underlying mechanisms, further large-scale randomized controlled are necessary.
Language: Английский
Citations
0
Neurophotonics, Journal Year: 2025, Volume and Issue: 12(01)
Published: Feb. 18, 2025
SignificanceAlzheimer's disease (AD) is a brain disorder characterized by its multifactorial nature and complex pathogenesis, highlighting the necessity for multimodal individualized interventions. Among emerging therapies, near-infrared (NIR) light treatment shows promise as therapeutic modality AD. However, existing clinical studies lack sufficient data on dosimetry, parameter optimization, dose–response.AimA versatile framework was developed to enable patient-individualized Monte Carlo simulation. A standardized dataset established, including digital phantoms derived from 20 AD patients who received NIR treatment.ApproachThe were synthesized mapped with multispectral optical parameters, integrating cortical parcellation, subcortical segmentation, sparse annotation. Structure-related fluence pathways dose–response relationships elucidated using simulation results cognitive/functional assessments.ResultsThe capability enhancing fidelity exploring verified standard templates data. Linear independence identified between changes in activities of daily living scale scores energy deposition gray matter.ConclusionsThe offers solution toward analysis, safety control translation multiple paradigms, demonstrating individualized, standardized, precise intervention planning.
Language: Английский
Citations
0
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0
Published: Jan. 1, 2024
Mitochondrial dysfunction plays a pivotal role in the development of age-related diseases, particularly neurodegenerative disorders. The etiology mitochondrial involves multitude factors that remain elusive. This review centers on elucidating role(s) excitotoxicity, oxytosis/ferroptosis and neurodegeneration within context bioenergetics, biogenesis, mitophagy oxidative stress explores their intricate interplay pathogenesis diseases. effective coordination turnover processes, notably is assumed to be critically important for cellular resilience longevity. However, age-associated decrease impedes elimination dysfunctional mitochondria, consequently impairing biogenesis. deleterious cascade results accumulation damaged mitochondria deterioration functions. Both excitotoxicity have been demonstrated contribute significantly pathophysiology including Alzheimer's disease (AD), Parkinson's (PD), Huntington's Disease (HD), Amyotrophic Lateral Sclerosis (ALS) Multiple (MS). Excitotoxicity, characterized by excessive glutamate signaling, initiates events involving calcium dysregulation, energy depletion, intricately linked dysfunction. Furthermore, emerging concepts surrounding underscore importance iron-dependent lipid peroxidation engagement neurodegeneration. not only discusses individual contributions ferroptosis but also emphasizes convergence with dysfunction, key driver Understanding crosstalk between oxytosis/ferroptosis, holds potential pave way mitochondrion-targeted therapeutic strategies. Such strategies, focus mitophagy, stress, emerge as promising avenues intervention.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9690 - 9690
Published: Sept. 7, 2024
Alzheimer’s disease (AD) still prevails and continues to increase indiscriminately throughout the 21st century, is thus responsible for depreciating quality of health associated sectors. AD a progressive neurodegenerative disorder marked by significant amassment beta-amyloid plaques neurofibrillary tangles near hippocampus, leading consequent loss cognitive abilities. Conventionally, amyloid tau hypotheses have been established as most prominent in providing detailed insight into pathogenesis revealing associative biomarkers intricately involved progression. Nanotheranostic deliberates rational thought toward designing efficacious nanosystems strategic endeavors diagnosis therapeutic implications. The exceeding advancements this field enable scientific community envisage conceptualize pharmacokinetic monitoring drug, sustained targeted drug delivery responses, fabrication anti-amyloid therapeutics, enhanced accumulation across blood–brain barrier (BBB), giving an optimistic approach towards personalized precision medicine. Current methods idealized on design bioengineering array nanoparticulate systems offer higher affinity neurocapillary endothelial cells BBB. They recently attracted intriguing attention early diagnostic measures taken manage progression disease. In article, we tend furnish comprehensive outlook, mechanism conventional pathogenesis, new findings. We also summarize shortcomings diagnostic, prognostic, approaches undertaken alleviate AD, unique window nanotheranostic without disregarding potential drawbacks, side effects, safety concerns.
Language: Английский
Citations
3